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Fusion gene ID: 36699 |
FusionGeneSummary for SUB1_ECT2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SUB1_ECT2 | Fusion gene ID: 36699 | Hgene | Tgene | Gene symbol | SUB1 | ECT2 | Gene ID | 10923 | 1894 |
Gene name | SUB1 homolog, transcriptional regulator | epithelial cell transforming 2 | |
Synonyms | P15|PC4|p14 | ARHGEF31 | |
Cytomap | 5p13.3 | 3q26.31 | |
Type of gene | protein-coding | protein-coding | |
Description | activated RNA polymerase II transcriptional coactivator p15activated RNA polymerase II transcription cofactor 4positive cofactor 4 | protein ECT2epithelial cell-transforming sequence 2 oncogene | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P53999 | Q9H8V3 | |
Ensembl transtripts involved in fusion gene | ENST00000512913, ENST00000265073, ENST00000515355, ENST00000502897, ENST00000504789, | ENST00000232458, ENST00000392692, ENST00000427830, ENST00000417960, ENST00000441497, ENST00000540509, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 5 X 5 X 2=50 |
# samples | 7 | 6 | |
** MAII score | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SUB1 [Title/Abstract] AND ECT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SUB1 | GO:0006357 | regulation of transcription by RNA polymerase II | 8062391 |
Tgene | ECT2 | GO:0032147 | activation of protein kinase activity | 15254234 |
Tgene | ECT2 | GO:0032467 | positive regulation of cytokinesis | 15545273 |
Tgene | ECT2 | GO:0043065 | positive regulation of apoptotic process | 21373644 |
Tgene | ECT2 | GO:0043547 | positive regulation of GTPase activity | 17115030|19617897|20047078 |
Tgene | ECT2 | GO:0045859 | regulation of protein kinase activity | 15254234 |
Tgene | ECT2 | GO:0051260 | protein homooligomerization | 15545273 |
Tgene | ECT2 | GO:0070301 | cellular response to hydrogen peroxide | 21373644 |
Tgene | ECT2 | GO:0071277 | cellular response to calcium ion | 15254234 |
Tgene | ECT2 | GO:0071479 | cellular response to ionizing radiation | 21373644 |
Tgene | ECT2 | GO:0090630 | activation of GTPase activity | 19617897 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-DS-A1OC-01A | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000512913 | ENST00000232458 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000512913 | ENST00000392692 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000512913 | ENST00000427830 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000512913 | ENST00000417960 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000512913 | ENST00000441497 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000512913 | ENST00000540509 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000232458 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000392692 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000427830 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000417960 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000441497 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000265073 | ENST00000540509 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000232458 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000392692 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000427830 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000417960 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000441497 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000515355 | ENST00000540509 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000232458 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000392692 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000427830 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000417960 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000441497 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
5UTR-3CDS | ENST00000502897 | ENST00000540509 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000232458 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000392692 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000427830 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000417960 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000441497 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
intron-3CDS | ENST00000504789 | ENST00000540509 | SUB1 | chr5 | 32585731 | + | ECT2 | chr3 | 172479400 | + |
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FusionProtFeatures for SUB1_ECT2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SUB1 | ECT2 |
General coactivator that functions cooperatively withTAFs and mediates functional interactions between upstreamactivators and the general transcriptional machinery. May beinvolved in stabilizing the multiprotein transcription complex.Binds single-stranded DNA. Also binds, in vitro, non-specificallyto double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275,ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453,ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392,ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}. | Guanine nucleotide exchange factor (GEF) that catalyzesthe exchange of GDP for GTP. Promotes guanine nucleotide exchangeon the Rho family members of small GTPases, like RHOA, RHOC, RAC1and CDC42. Required for signal transduction pathways involved inthe regulation of cytokinesis. Component of the centralspindlincomplex that serves as a microtubule-dependent and Rho-mediatedsignaling required for the myosin contractile ring formationduring the cell cycle cytokinesis. Regulates the translocation ofRHOA from the central spindle to the equatorial region. Plays arole in the control of mitotic spindle assembly; regulates theactivation of CDC42 in metaphase for the process of spindle fibersattachment to kinetochores before chromosome congression. Involvedin the regulation of epithelial cell polarity; participates in theformation of epithelial tight junctions in a polarity complexPARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role inthe regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity ofRAC1 through its association with the oncogenic PARD6A-PRKCIcomplex in cancer cells, thereby acting to coordinately drivetumor cell proliferation and invasion. Also stimulates genotoxicstress-induced RHOB activity in breast cancer cells leading totheir cell death. {ECO:0000269|PubMed:10579713,ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234,ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345,ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035,ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300,ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248,ECO:0000269|PubMed:21373644}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SUB1_ECT2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SUB1_ECT2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SUB1 | CSTF2, EP300, HNF4A, SUB1, SP1, PSIP1, POU2AF1, BANF1, REST, RCOR1, CBX5, POLR2A, POLR2B, HDGF, ELAVL1, GTF3C1, CDK2, APP, CDC5L, RPL18A, LAMP2, SMURF1, FN1, CSNK2A1, CLK4, HUWE1, ABL1, UNK, ABCF1, CHD5, EIF1AX, EIF2S2, EIF2S3, NACA, NOLC1, POLR3C, SART1, SBNO1, SET, SRRM2, SRSF1, SRSF2, SRSF6, ACIN1, ARGLU1, CHD4, EIF3I, HSPA5, KPNA1, MATR3, RANGAP1, ST13, TP53BP1, TROVE2, SUPT5H, TPM2, TSR1, SFN, MCM2, UBR5, EGFR, CDC14B, FAN1, COPZ1, SARNP, CHORDC1, DIS3, SEPT7, PRCC, CDK5, SH3GLB1, SCYL2, DRG1, DLD, DNM1L, TRIM25, DEAF1, SP3 | ECT2 | PARD6A, KLHL20, PRKCZ, PARD3, RACGAP1, ABR, CD19, CSTB, EIF4A2, MBD1, MT2A, COX2, PCOLCE, PSMA6, RPS20, TCEB1, UBB, VDAC2, CHST10, EIF5B, NPC2, ILVBL, SNRNP200, NOMO1, ERAL1, POMP, C2orf42, CCDC91, OTUB1, THAP11, FANCM, SPATA22, GGN, OOSP2, CRIPAK, ALDH1B1, ATP2A2, CAPN1, CAPN2, CAPZA1, CDK5, CFL1, AP3S1, SLC25A10, CTBP1, CTBP2, CUX1, CYC1, DYNC1I2, ACSL1, FHL3, FLNA, XRCC6, GALK1, HNRNPC, HOXB9, EIF6, KPNB1, LDHA, LDHB, MCM6, MYO1D, NUMA1, NUP98, PDHB, PML, PPM1G, PPP1CA, PPP2CA, MAPK1, PSMD4, ABCD3, RFC2, RFC5, RPN1, SRSF1, SLC1A5, STRN, TCEB3, TCOF1, TP53, XRCC5, YWHAB, YWHAZ, USP11, USP9X, ARID1A, SLC25A11, SUCLG2, SUCLG1, TRIP13, GTF3C5, NPEPPS, RNF14, NUP93, UBE3C, GNB2L1, UNC13B, MYL12A, AHCYL1, CPSF4, CKAP4, IMMT, WDHD1, STRAP, XPOT, COPE, PHB2, KDM1A, TBC1D2B, LARP1, SIRT1, NUP188, PHGDH, COPG2, PELP1, STOML2, NUB1, PELO, CPSF2, DCAF16, CHCHD3, AGGF1, PPP6R3, IPO9, CAND1, RAD18, CCDC47, ESYT2, MICAL3, UBE2O, LPCAT1, PUS1, LAS1L, SLFN11, PPP1R18, PGAM5, CDH1, SRPK2, RPGRIP1L, GPSM2, SAMD1, RBM45, SKA3, WDR5, FOXM1, CDC5L, ARIH1, GKAP1, NPHP4 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SUB1_ECT2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SUB1_ECT2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ECT2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |