FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36632

FusionGeneSummary for STX16_NEDD4L

check button Fusion gene summary
Fusion gene informationFusion gene name: STX16_NEDD4L
Fusion gene ID: 36632
HgeneTgene
Gene symbol

STX16

NEDD4L

Gene ID

8675

23327

Gene namesyntaxin 16neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
SynonymsSYN16NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap

20q13.32

18q21.31

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-16E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5
Modification date2018052320180523
UniProtAcc

O14662

Q96PU5

Ensembl transtripts involved in fusion geneENST00000355957, ENST00000361770, 
ENST00000359617, ENST00000371141, 
ENST00000371132, ENST00000496003, 
ENST00000358029, ENST00000361830, 
ENST00000356462, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000382850, ENST00000256830, 
ENST00000588516, ENST00000456986, 
ENST00000435432, ENST00000357895, 
ENST00000586263, ENST00000456173, 
ENST00000431212, 
Fusion gene scores* DoF score4 X 4 X 3=4813 X 14 X 6=1092
# samples 516
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STX16 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTX16

GO:0042147

retrograde transport, endosome to Golgi

15215310|18195106

TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF378130STX16chr20

57236433

+NEDD4Lchr18

56065315

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000355957ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000355957ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000355957ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000355957ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000355957ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000355957ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361770ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361770ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361770ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361770ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361770ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000359617ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000359617ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000359617ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000359617ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000359617ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371141ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371141ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371141ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371141ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371141ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371132ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371132ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371132ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000371132ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000371132ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000496003ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000496003ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000496003ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000496003ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000496003ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000358029ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000358029ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000358029ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000358029ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000358029ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000356462STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000400345STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000589054STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361830ENST00000256832STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361830ENST00000382850STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000256830STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000588516STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361830ENST00000456986STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000435432STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000357895STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000586263STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-3UTRENST00000361830ENST00000456173STX16chr20

57236433

+NEDD4Lchr18

56065315

-
intron-intronENST00000361830ENST00000431212STX16chr20

57236433

+NEDD4Lchr18

56065315

-

Top

FusionProtFeatures for STX16_NEDD4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STX16

O14662

NEDD4L

Q96PU5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STX16_NEDD4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STX16_NEDD4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STX16_NEDD4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STX16_NEDD4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNEDD4LC0020538Hypertensive disease2CTD_human
TgeneNEDD4LC0008925Cleft Palate1CTD_human
TgeneNEDD4LC0014175Endometriosis1CTD_human
TgeneNEDD4LC0039075Syndactyly1CTD_human
TgeneNEDD4LC1868720Periventricular Nodular Heterotopia1CTD_human;ORPHANET