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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36631

FusionGeneSummary for STX16_MYT1

check button Fusion gene summary
Fusion gene informationFusion gene name: STX16_MYT1
Fusion gene ID: 36631
HgeneTgene
Gene symbol

STX16

MYT1

Gene ID

8675

9088

Gene namesyntaxin 16protein kinase, membrane associated tyrosine/threonine 1
SynonymsSYN16MYT1|PPP1R126
Cytomap

20q13.32

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-16membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasemyt1 kinaseprotein phosphatase 1, regulatory subunit 126
Modification date2018052320180523
UniProtAcc

O14662

Q01538

Ensembl transtripts involved in fusion geneENST00000355957, ENST00000361770, 
ENST00000359617, ENST00000371141, 
ENST00000371132, ENST00000496003, 
ENST00000358029, ENST00000361830, 
ENST00000360149, ENST00000536311, 
ENST00000328439, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 52
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: STX16 [Title/Abstract] AND MYT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTX16

GO:0042147

retrograde transport, endosome to Golgi

15215310|18195106

TgeneMYT1

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A0FV-01ASTX16chr20

57227143

+MYT1chr20

62821416

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355957ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000355957ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000355957ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361770ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361770ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361770ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5UTR-5UTRENST00000359617ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5UTR-5UTRENST00000359617ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5UTR-5UTRENST00000359617ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371141ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371141ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371141ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371132ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371132ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000371132ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
3UTR-5UTRENST00000496003ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
3UTR-5UTRENST00000496003ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
3UTR-5UTRENST00000496003ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000358029ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000358029ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000358029ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361830ENST00000360149STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361830ENST00000536311STX16chr20

57227143

+MYT1chr20

62821416

+
5CDS-5UTRENST00000361830ENST00000328439STX16chr20

57227143

+MYT1chr20

62821416

+

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FusionProtFeatures for STX16_MYT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STX16

O14662

MYT1

Q01538

Binds to the promoter region of genes encodingproteolipid proteins of the central nervous system. May play arole in the development of neurons and oligodendroglia in the CNS.May regulate a critical transition point in oligodendrocytelineage development by modulating oligodendrocyte progenitorproliferation relative to terminal differentiation and up-regulation of myelin gene transcription.{ECO:0000269|PubMed:14962745}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STX16_MYT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STX16_MYT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STX16VAMP4, VAMP3, PTPN12, MEOX2, STX4, VAMP5, NAPB, ZDHHC17, ATP6V1B2, NAPA, TMEM17, RHOU, PPM1H, DUSP22, VPS45, STX7, TRIM25MYT1PIN1, SIN3B, HDAC1, TRAF3, AURKA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STX16_MYT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STX16_MYT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource