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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36610

FusionGeneSummary for STRN_TGFBR2

check button Fusion gene summary
Fusion gene informationFusion gene name: STRN_TGFBR2
Fusion gene ID: 36610
HgeneTgene
Gene symbol

STRN

TGFBR2

Gene ID

6801

7048

Gene namestriatintransforming growth factor beta receptor 2
SynonymsPPP2R6A|SG2NA|STRN1AAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TBR-ii|TBRII|TGFR-2|TGFbeta-RII
Cytomap

2p22.2

3p24.1

Type of geneprotein-codingprotein-coding
Descriptionstriatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding proteinTGF-beta receptor type-2TGF-beta receptor type IIBTGF-beta type II receptortbetaR-IItransforming growth factor beta receptor IItransforming growth factor beta receptor type IICtransforming growth factor, beta receptor II (70/80kDa)transforming grow
Modification date2018052320180527
UniProtAcc

O43815

P37173

Ensembl transtripts involved in fusion geneENST00000263918, ENST00000379213, 
ENST00000295754, ENST00000359013, 
Fusion gene scores* DoF score5 X 6 X 7=2104 X 4 X 1=16
# samples 84
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STRN [Title/Abstract] AND TGFBR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTGFBR2

GO:0006468

protein phosphorylation

12015308

TgeneTGFBR2

GO:0006915

apoptotic process

17471240

TgeneTGFBR2

GO:0007179

transforming growth factor beta receptor signaling pathway

18453574

TgeneTGFBR2

GO:0010718

positive regulation of epithelial to mesenchymal transition

26459119

TgeneTGFBR2

GO:0018105

peptidyl-serine phosphorylation

12015308

TgeneTGFBR2

GO:0018107

peptidyl-threonine phosphorylation

12015308

TgeneTGFBR2

GO:0042493

response to drug

17878231

TgeneTGFBR2

GO:0060389

pathway-restricted SMAD protein phosphorylation

18453574

TgeneTGFBR2

GO:0070723

response to cholesterol

17878231

TgeneTGFBR2

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

17164348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D50683STRNchr2

37096015

-TGFBR2chr3

30648321

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000263918ENST00000295754STRNchr2

37096015

-TGFBR2chr3

30648321

+
intron-5UTRENST00000263918ENST00000359013STRNchr2

37096015

-TGFBR2chr3

30648321

+
intron-5UTRENST00000379213ENST00000295754STRNchr2

37096015

-TGFBR2chr3

30648321

+
intron-5UTRENST00000379213ENST00000359013STRNchr2

37096015

-TGFBR2chr3

30648321

+

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FusionProtFeatures for STRN_TGFBR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRN

O43815

TGFBR2

P37173

Calmodulin-binding protein which may function asscaffolding or signaling protein and may play a role in dendriticCa(2+) signaling. Transmembrane serine/threonine kinase forming with theTGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 andTGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cellsurface to the cytoplasm and is thus regulating a plethora ofphysiological and pathological processes including cell cyclearrest in epithelial and hematopoietic cells, control ofmesenchymal cell proliferation and differentiation, wound healing,extracellular matrix production, immunosuppression andcarcinogenesis. The formation of the receptor complex composed of2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to thecytokine dimer results in the phosphorylation and the activationof TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1phosphorylates SMAD2 which dissociates from the receptor andinteracts with SMAD4. The SMAD2-SMAD4 complex is subsequentlytranslocated to the nucleus where it modulates the transcriptionof the TGF-beta-regulated genes. This constitutes the canonicalSMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.{ECO:0000269|PubMed:7774578}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STRN_TGFBR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STRN_TGFBR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STRN_TGFBR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTGFBR2P37173DB09462GlycerinTGF-beta receptor type-2small moleculeapproved|investigational

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RelatedDiseases for STRN_TGFBR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTGFBR2C2674574Aortic aneurysm, familial thoracic 311CTD_human;ORPHANET;UNIPROT
TgeneTGFBR2C2697932Loeys-Dietz Syndrome5CTD_human
TgeneTGFBR2C0002949Aneurysm, Dissecting2CTD_human;HPO
TgeneTGFBR2C0023893Liver Cirrhosis, Experimental2CTD_human
TgeneTGFBR2C0376634Craniofacial Abnormalities2CTD_human
TgeneTGFBR2C0920269Microsatellite Instability2CTD_human
TgeneTGFBR2C1860896COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 62UNIPROT
TgeneTGFBR2C0003486Aortic Aneurysm1CTD_human;HPO
TgeneTGFBR2C0005940Bone Diseases1CTD_human
TgeneTGFBR2C0005967Bone neoplasms1CTD_human
TgeneTGFBR2C0009375Colonic Neoplasms1CTD_human
TgeneTGFBR2C0009405Hereditary Nonpolyposis Colorectal Neoplasms1CTD_human
TgeneTGFBR2C0011881Diabetic Nephropathy1CTD_human
TgeneTGFBR2C0014859Esophageal Neoplasms1CTD_human
TgeneTGFBR2C0015393Eye Abnormalities1CTD_human
TgeneTGFBR2C0015672Fatigue1CTD_human;HPO
TgeneTGFBR2C0019294Hernia, Inguinal1CTD_human
TgeneTGFBR2C0024121Lung Neoplasms1CTD_human
TgeneTGFBR2C0024796Marfan Syndrome1CTD_human
TgeneTGFBR2C0027627Neoplasm Metastasis1CTD_human
TgeneTGFBR2C0033578Prostatic Neoplasms1CTD_human
TgeneTGFBR2C0036341Schizophrenia1PSYGENET
TgeneTGFBR2C0149931Migraine Disorders1CTD_human;HPO
TgeneTGFBR2C0152018Esophageal carcinoma1HPO;UNIPROT
TgeneTGFBR2C0162872Aortic Aneurysm, Thoracic1CTD_human