FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36597

FusionGeneSummary for STRN3_MAP3K3

check button Fusion gene summary
Fusion gene informationFusion gene name: STRN3_MAP3K3
Fusion gene ID: 36597
HgeneTgene
Gene symbol

STRN3

MAP3K3

Gene ID

29966

4215

Gene namestriatin 3mitogen-activated protein kinase kinase kinase 3
SynonymsPPP2R6B|S/G2NA|SG2NAMAPKKK3|MEKK3
Cytomap

14q12

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionstriatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3
Modification date2018052320180529
UniProtAcc

Q13033

Q99759

Ensembl transtripts involved in fusion geneENST00000355683, ENST00000357479, 
ENST00000366206, 
ENST00000579585, 
ENST00000584573, ENST00000361733, 
ENST00000361357, ENST00000577395, 
ENST00000577784, 
Fusion gene scores* DoF score10 X 5 X 7=3508 X 6 X 3=144
# samples 119
** MAII scorelog2(11/350*10)=-1.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STRN3 [Title/Abstract] AND MAP3K3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP3K3

GO:0035556

intracellular signal transduction

15001576

TgeneMAP3K3

GO:0046777

protein autophosphorylation

15001576


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV655690STRN3chr14

31487938

-MAP3K3chr17

61748907

+
ChiTaRS3.1AV655638STRN3chr14

31487938

-MAP3K3chr17

61748907

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000355683ENST00000579585STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000355683ENST00000584573STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000355683ENST00000361733STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000355683ENST00000361357STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000355683ENST00000577395STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000355683ENST00000577784STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000579585STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000584573STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000361733STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000361357STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000577395STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000357479ENST00000577784STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000579585STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000584573STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000361733STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000361357STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000577395STRN3chr14

31487938

-MAP3K3chr17

61748907

+
intron-intronENST00000366206ENST00000577784STRN3chr14

31487938

-MAP3K3chr17

61748907

+

Top

FusionProtFeatures for STRN3_MAP3K3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRN3

Q13033

MAP3K3

Q99759

Binds calmodulin in a calcium dependent manner. Mayfunction as scaffolding or signaling protein. Component of a protein kinase signal transductioncascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3transcriptional regulators. {ECO:0000269|PubMed:12912994,ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216,ECO:0000269|PubMed:9006902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STRN3_MAP3K3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STRN3_MAP3K3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STRN3_MAP3K3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STRN3_MAP3K3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAP3K3C0014859Esophageal Neoplasms1CTD_human