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Fusion gene ID: 36596 |
FusionGeneSummary for STRN3_MAML3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STRN3_MAML3 | Fusion gene ID: 36596 | Hgene | Tgene | Gene symbol | STRN3 | MAML3 | Gene ID | 29966 | 55534 |
| Gene name | striatin 3 | mastermind like transcriptional coactivator 3 | |
| Synonyms | PPP2R6B|S/G2NA|SG2NA | CAGH3|ERDA3|GDN|MAM-2|MAM2|TNRC3|mam-3 | |
| Cytomap | 14q12 | 4q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | striatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3 | mastermind-like protein 3CAG repeat containing (glia-derived nexin I alpha)expanded repeat domain, CAG/CTG 3polyglutamine richtrinucleotide repeat containing 3 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q13033 | Q96JK9 | |
| Ensembl transtripts involved in fusion gene | ENST00000355683, ENST00000357479, ENST00000366206, | ENST00000509479, ENST00000327122, ENST00000398940, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 7 X 4 X 4=112 |
| # samples | 11 | 14 | |
| ** MAII score | log2(11/350*10)=-1.66985139830767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/112*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STRN3 [Title/Abstract] AND MAML3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAML3 | GO:0007219 | Notch signaling pathway | 12370315 |
| Tgene | MAML3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-A1EJ-01A | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355683 | ENST00000509479 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| 5CDS-intron | ENST00000355683 | ENST00000327122 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| 5CDS-intron | ENST00000355683 | ENST00000398940 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| In-frame | ENST00000357479 | ENST00000509479 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| 5CDS-intron | ENST00000357479 | ENST00000327122 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| 5CDS-intron | ENST00000357479 | ENST00000398940 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| intron-3CDS | ENST00000366206 | ENST00000509479 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| intron-intron | ENST00000366206 | ENST00000327122 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
| intron-intron | ENST00000366206 | ENST00000398940 | STRN3 | chr14 | 31495110 | - | MAML3 | chr4 | 140651821 | - |
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FusionProtFeatures for STRN3_MAML3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STRN3 | MAML3 |
| Binds calmodulin in a calcium dependent manner. Mayfunction as scaffolding or signaling protein. | Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 6_13 | 94 | 714 | Compositional bias | Note=Poly-Gly |
| Hgene | STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 6_13 | 94 | 798 | Compositional bias | Note=Poly-Gly |
| Hgene | STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 71_79 | 94 | 714 | Region | Caveolin-binding |
| Hgene | STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 71_79 | 94 | 798 | Region | Caveolin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 77_136 | 94 | 714 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 77_136 | 94 | 798 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 166_183 | 94 | 714 | Region | Calmodulin-binding |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 166_183 | 94 | 798 | Region | Calmodulin-binding |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 478_517 | 94 | 714 | Repeat | Note=WD 1 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 531_570 | 94 | 714 | Repeat | Note=WD 2 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 584_623 | 94 | 714 | Repeat | Note=WD 3 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 679_718 | 94 | 714 | Repeat | Note=WD 4 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 721_760 | 94 | 714 | Repeat | Note=WD 5 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000355683 | - | 1 | 16 | 767_796 | 94 | 714 | Repeat | Note=WD 6 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 478_517 | 94 | 798 | Repeat | Note=WD 1 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 531_570 | 94 | 798 | Repeat | Note=WD 2 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 584_623 | 94 | 798 | Repeat | Note=WD 3 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 679_718 | 94 | 798 | Repeat | Note=WD 4 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 721_760 | 94 | 798 | Repeat | Note=WD 5 |
| Hgene | >STRN3 | chr14:31495110 | chr4:140651821 | ENST00000357479 | - | 1 | 18 | 767_796 | 94 | 798 | Repeat | Note=WD 6 |
| Tgene | MAML3 | chr14:31495110 | chr4:140651821 | ENST00000509479 | - | 1 | 5 | 467_968 | 693 | 1139 | Compositional bias | Note=Gln-rich |
| Tgene | MAML3 | chr14:31495110 | chr4:140651821 | ENST00000509479 | - | 1 | 5 | 548_595 | 693 | 1139 | Compositional bias | Note=Asn-rich |
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FusionGeneSequence for STRN3_MAML3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_540aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQL QQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQP GMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQG AQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMS GLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNPX >In-frame_STRN3_ENST00000357479_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_540aa MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER AELQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQL QQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQP GMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQG AQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMS GLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNPX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_1620nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGAGCAGCATCCAGTTGGACTTCCCCGAACCACAGGCCCCATGCAGTCCTCCGTGCCCCCAGGCTCAGGTGGCATGGTC TCAGGAGCCAGTCCCGCAGGCCCCGGCTTCCTGGGCAGCCAGCCCCAAGCAGCCATCATGAAGCAGATGCTCATTGATCAGCGGGCCCAG TTGATAGAGCAGCAGAAGCAACAGTTCCTGCGGGAGCAAAGGCAGCAGCAGCAGCAGCAGCAGCAGCAGATTTTGGCGGAACAGCAGTTG CAGCAATCACATCTACCCCGGCAGCACCTCCAGCCACAGCGGAATCCATACCCAGTGCAGCAGGTCAATCAGTTTCAAGGTTCTCCCCAG GATATAGCAGCCGTAAGAAGCCAAGCAGCCCTCCAGAGCATGCGAACGTCACGGCTGATGGCACAGAACGCAGGCATGATGGGAATAGGA CCCTCCCAGAACCCTGGGACGATGGCCACCGCAGCTGCGCAGTCGGAGATGGGACTGGCCCCTTATAGCACCACGCCTACCAGCCAACCA GGAATGTACAATATGAGCACAGGCATGACCCAAATGTTGCAGCATCCAAACCAAAGTGGCATGAGCATCACACATAACCAAGCCCAGGGA CCGAGGCAACCTGCCTCTGGGCAGGGGGTTGGAATGGTGAGTGGCTTTGGTCAGAGCATGCTGGTGAACTCAGCCATTACCCAGCAACAT CCACAGATGAAAGGGCCAGTAGGCCAGGCCTTGCCTAGGCCCCAAGCCCCTCCAAGGCTGCAGAGCCTTATGGGAACAGTCCAGCAAGGA GCACAAAGCTGGCAACAGAGGAGCTTGCAGGGCATGCCTGGGAGGACTAGTGGAGAATTGGGACCATTCAACAATGGCGCCAGCTACCCT CTTCAAGCTGGGCAGCCGAGACTGACCAAGCAGCACTTCCCACAGGGACTGAGCCAGTCAGTCGTGGATGCTAACACGGGCACAGTGAGG ACCCTCAACCCAGCTGCCATGGGTCGGCAGATGATGCCATCGCTCCCGGGGCAGCAAGGCACCAGCCAGGCGAGGCCAATGGTCATGTCT GGCCTGAGCCAGGGAGTCCCAGGCATGCCAGCGTTCAGCCAGCCCCCAGCACAGCAGCAGATACCCAGTGGCAGCTTTGCTCCAAGCAGC CAGAGCCAAGCCTATGAGCGGAATGCCCCTCAGGACGTGTCATACAATTACAGTGGCGACGGAGCTGGGGGTTCCTTCCCTGGCCTCCCG GACGGTGCAGACCTTGTGGACTCCATCATCAAAGGCGGGCCAGGGGACGAGTGGATGCAGGAGCTTGATGAATTGTTTGGTAACCCCTAA >In-frame_STRN3_ENST00000357479_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_1620nt ATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTT TCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCG CAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGG GCCGAACTGCAGGAGCAGCATCCAGTTGGACTTCCCCGAACCACAGGCCCCATGCAGTCCTCCGTGCCCCCAGGCTCAGGTGGCATGGTC TCAGGAGCCAGTCCCGCAGGCCCCGGCTTCCTGGGCAGCCAGCCCCAAGCAGCCATCATGAAGCAGATGCTCATTGATCAGCGGGCCCAG TTGATAGAGCAGCAGAAGCAACAGTTCCTGCGGGAGCAAAGGCAGCAGCAGCAGCAGCAGCAGCAGCAGATTTTGGCGGAACAGCAGTTG CAGCAATCACATCTACCCCGGCAGCACCTCCAGCCACAGCGGAATCCATACCCAGTGCAGCAGGTCAATCAGTTTCAAGGTTCTCCCCAG GATATAGCAGCCGTAAGAAGCCAAGCAGCCCTCCAGAGCATGCGAACGTCACGGCTGATGGCACAGAACGCAGGCATGATGGGAATAGGA CCCTCCCAGAACCCTGGGACGATGGCCACCGCAGCTGCGCAGTCGGAGATGGGACTGGCCCCTTATAGCACCACGCCTACCAGCCAACCA GGAATGTACAATATGAGCACAGGCATGACCCAAATGTTGCAGCATCCAAACCAAAGTGGCATGAGCATCACACATAACCAAGCCCAGGGA CCGAGGCAACCTGCCTCTGGGCAGGGGGTTGGAATGGTGAGTGGCTTTGGTCAGAGCATGCTGGTGAACTCAGCCATTACCCAGCAACAT CCACAGATGAAAGGGCCAGTAGGCCAGGCCTTGCCTAGGCCCCAAGCCCCTCCAAGGCTGCAGAGCCTTATGGGAACAGTCCAGCAAGGA GCACAAAGCTGGCAACAGAGGAGCTTGCAGGGCATGCCTGGGAGGACTAGTGGAGAATTGGGACCATTCAACAATGGCGCCAGCTACCCT CTTCAAGCTGGGCAGCCGAGACTGACCAAGCAGCACTTCCCACAGGGACTGAGCCAGTCAGTCGTGGATGCTAACACGGGCACAGTGAGG ACCCTCAACCCAGCTGCCATGGGTCGGCAGATGATGCCATCGCTCCCGGGGCAGCAAGGCACCAGCCAGGCGAGGCCAATGGTCATGTCT GGCCTGAGCCAGGGAGTCCCAGGCATGCCAGCGTTCAGCCAGCCCCCAGCACAGCAGCAGATACCCAGTGGCAGCTTTGCTCCAAGCAGC CAGAGCCAAGCCTATGAGCGGAATGCCCCTCAGGACGTGTCATACAATTACAGTGGCGACGGAGCTGGGGGTTCCTTCCCTGGCCTCCCG GACGGTGCAGACCTTGTGGACTCCATCATCAAAGGCGGGCCAGGGGACGAGTGGATGCAGGAGCTTGATGAATTGTTTGGTAACCCCTAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STRN3_ENST00000355683_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_4406nt AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGGAGCAGCATCCAGTTGGACTTCCCCGAACCACAGGCCCCATG CAGTCCTCCGTGCCCCCAGGCTCAGGTGGCATGGTCTCAGGAGCCAGTCCCGCAGGCCCCGGCTTCCTGGGCAGCCAGCCCCAAGCAGCC ATCATGAAGCAGATGCTCATTGATCAGCGGGCCCAGTTGATAGAGCAGCAGAAGCAACAGTTCCTGCGGGAGCAAAGGCAGCAGCAGCAG CAGCAGCAGCAGCAGATTTTGGCGGAACAGCAGTTGCAGCAATCACATCTACCCCGGCAGCACCTCCAGCCACAGCGGAATCCATACCCA GTGCAGCAGGTCAATCAGTTTCAAGGTTCTCCCCAGGATATAGCAGCCGTAAGAAGCCAAGCAGCCCTCCAGAGCATGCGAACGTCACGG CTGATGGCACAGAACGCAGGCATGATGGGAATAGGACCCTCCCAGAACCCTGGGACGATGGCCACCGCAGCTGCGCAGTCGGAGATGGGA CTGGCCCCTTATAGCACCACGCCTACCAGCCAACCAGGAATGTACAATATGAGCACAGGCATGACCCAAATGTTGCAGCATCCAAACCAA AGTGGCATGAGCATCACACATAACCAAGCCCAGGGACCGAGGCAACCTGCCTCTGGGCAGGGGGTTGGAATGGTGAGTGGCTTTGGTCAG AGCATGCTGGTGAACTCAGCCATTACCCAGCAACATCCACAGATGAAAGGGCCAGTAGGCCAGGCCTTGCCTAGGCCCCAAGCCCCTCCA AGGCTGCAGAGCCTTATGGGAACAGTCCAGCAAGGAGCACAAAGCTGGCAACAGAGGAGCTTGCAGGGCATGCCTGGGAGGACTAGTGGA GAATTGGGACCATTCAACAATGGCGCCAGCTACCCTCTTCAAGCTGGGCAGCCGAGACTGACCAAGCAGCACTTCCCACAGGGACTGAGC CAGTCAGTCGTGGATGCTAACACGGGCACAGTGAGGACCCTCAACCCAGCTGCCATGGGTCGGCAGATGATGCCATCGCTCCCGGGGCAG CAAGGCACCAGCCAGGCGAGGCCAATGGTCATGTCTGGCCTGAGCCAGGGAGTCCCAGGCATGCCAGCGTTCAGCCAGCCCCCAGCACAG CAGCAGATACCCAGTGGCAGCTTTGCTCCAAGCAGCCAGAGCCAAGCCTATGAGCGGAATGCCCCTCAGGACGTGTCATACAATTACAGT GGCGACGGAGCTGGGGGTTCCTTCCCTGGCCTCCCGGACGGTGCAGACCTTGTGGACTCCATCATCAAAGGCGGGCCAGGGGACGAGTGG ATGCAGGAGCTTGATGAATTGTTTGGTAACCCCTAATCAAGAGAGGCCCCAAGATCCACAACTCGAGTGGTTAAAGCTTAAAAAGTGAAA AAGAAACAGGATGTTGACCCATCCTTGTTTTTTGTTTTTTTGACCCACGTAAACTGAGCAAAACTGCAGCTGGCTGACAATGGAAGATCC AGGTGCCAATCCACAGCCCCACCAGGCCTCATTTCACCTGATTTTCACACAGCAATCGAGATGAGACGCCATGCAGATCCCGGCTGCGAG AGAGGGAGACACCCGGAGGAGCAGGTGGGAAGATGAAGCCGGCCAGAGCCCCTCTGCCCAGCATGCCCTGTGATCGCCTGGCCCAGCAGG AGCTGCTTCAGCCGAGAGGGACTATTACCCAAGAGAGGTATCCTCAGCCCCTCCTGCCCCAGGTCGGGAGACAGCAGCTTTGGAGACACA AAAGAGACAGAGCCTCAGCCAGGGAGAGTGAGTCCCCCAGAAGAGGCTGGGTGGTTGCACAGGCCAGGTGCACAGGTTGGAAATGCACTG AACTCTGGGTGCCGAGAGATGTAAGGCTTTGAGACATGCTACTGAATTTGGAGGGCAGGCACGAAGAACAGTGAGATTGTCAAAAGGAGA CAACCACAGATCCTACAGGACTGTCTGTCTCCTGCCCCATGATGACCCTCAGGAATTGCAAAGGCTCTGCTGTCACAAGGAGAGCAGGCT GAGTTTGGAGCAGGGTCCATCCGGCAGTCCTGGGACGGCTTCCCTCTGCTGGTGCCCCTGGTGGCAGTCCCTCCAGGTGGGGCTGGAGCC TGCTGGCGCCCAATACAAAACCCATACATCCAGGTGGGTCACATCTACTTCTGGCGGCCGCAGGGCAGGGAAACCCCTACTGGACCCTGT GTGTCTGCCAGCCTGGAGCCTTTGTCTCCAGCCCTGCCTTTATTCCTCCTTGCCTCCACACCAGCCTCCCCTTGCTTCTCCTTACAGACT ATCCAAGAAGTGAAGCTTATGTCTTTAGGGAGCCTTGGGCAGAGTCCACATAAATGCAGGAAGAACTTAGACAATGCCTGAAATGCAAAG GCGACACTGGAGTCTTCTTTCTCTAACGTGTAGCGTTGAATGAATATCTGCCTGGAACCAAGAGGGCTGCTCTGATGTTTGGGAGTCGGT TTTTTGTGAGCCACATCTGATATTTCTGATATCCCCAGGAAGGAGTGGCCTGGAGGTCACTGGTTCAGGCTCCCTTTGGGCGAAATCCTG GGAGTGATGCTCTAAAAATCCACCTTTCCCATCATCCCTACTCATCAGAAAGACAAATATAAAATCCCAGAGAGGTGGAGGAGCTAAAAA AGCAATTGCTCCACCTTACAAATTTGGATAGAAAGGAGATGTAGTTTATTTCATATGGGCAAAGTAGTCCTCTTCCAAAGTCCTGTACAG TTGTTCTCTGCAATTGACGCACATCTGCCCTAAGCGAAATCTGTCAGAAGGAATCAACAAGGCTCCTTGCCTCCCCTCCCAATCCCCCTT TTGGAGGACTTGTGGCTTCGGTGTCGTCCTAAGTGAGAGTGGCGTGTGCTTTTTTCCTGTCCCCTCCTCCCTCCGTGTCCTAGACGCTGG CTGCCTTCTGTGCACTCCCAGGCAGATCACTACGGAAGAGTCGGAGCCTGTGGGGTTGGACTGGCCACACTCAGTCCTGAGAAGGCGAGT TGCCATGGAAAGCTGGGGGCAGAGGTGTTTTTGGAGAGGAGGCGGCAGGCAAACATTGCCTTTGACTTGCTCTCCGCGTACCCGGGGTTG TAGAGCTGCTCAGGAAGGGGCAGGATGTAAGGCCAGAGGTGCCTGGTGGGTGAGAAGCCCAGGCAGGGGCTGGGCGCCCTCTCCGAAGAG GTGGCAGCAGGGTGACCCTGAACTCCCCAAATGGGGAGTGATGCCACTGGGGAAACTGAGTGGATCAAAGAGATGAAACCAAAAAAAAGC AAACAAACAAATGAGAAGACACAAAACATAATTACCTTTTCCTGAAAGGTACAGGAAATAAATATATAAGCAATGATGAGAAACTGGAGG TGGCTAATGGAAGTGAGACAGACAGGGGTGGGGGGCTCCATTATCTTTTAAAAGCTTCCTCCAAATGCTCAGTACTGGGACCAACTAATA GGTAGATTTTAATATGGTGGTTTTGTTTTGGTTTTGTTTTTACTACGGTGCTGATGTATATGTAATGTCTAAAAAAAGTTATTTGTACAT AAGTTTTTACAATACTGCAGATATCACTGGGTCTACTATCTGTAAAAAATATACATATAAATATATATATACTGTTTGTTTAAAATAGAG TATTTTTATTTCATTCCTTAACTCATCATCACAGCAGTGGTATTGCACTTCAGATGACATCTAATTACTAATTTGTACTGTATGACCTCT GGCAACTTGCTCCATTTTATTCAGATTTTTCTAGTTTTCTGTTTTTACTTTGTACATTGAGCATTGCTTATTTCCTTTTAAGAAATGTAC >In-frame_STRN3_ENST00000357479_chr14_31495110_-_MAML3_ENST00000509479_chr4_140651821_-_4387nt GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC ACTGGGAGGTGGAACGGGCCGAACTGCAGGAGCAGCATCCAGTTGGACTTCCCCGAACCACAGGCCCCATGCAGTCCTCCGTGCCCCCAG GCTCAGGTGGCATGGTCTCAGGAGCCAGTCCCGCAGGCCCCGGCTTCCTGGGCAGCCAGCCCCAAGCAGCCATCATGAAGCAGATGCTCA TTGATCAGCGGGCCCAGTTGATAGAGCAGCAGAAGCAACAGTTCCTGCGGGAGCAAAGGCAGCAGCAGCAGCAGCAGCAGCAGCAGATTT TGGCGGAACAGCAGTTGCAGCAATCACATCTACCCCGGCAGCACCTCCAGCCACAGCGGAATCCATACCCAGTGCAGCAGGTCAATCAGT TTCAAGGTTCTCCCCAGGATATAGCAGCCGTAAGAAGCCAAGCAGCCCTCCAGAGCATGCGAACGTCACGGCTGATGGCACAGAACGCAG GCATGATGGGAATAGGACCCTCCCAGAACCCTGGGACGATGGCCACCGCAGCTGCGCAGTCGGAGATGGGACTGGCCCCTTATAGCACCA CGCCTACCAGCCAACCAGGAATGTACAATATGAGCACAGGCATGACCCAAATGTTGCAGCATCCAAACCAAAGTGGCATGAGCATCACAC ATAACCAAGCCCAGGGACCGAGGCAACCTGCCTCTGGGCAGGGGGTTGGAATGGTGAGTGGCTTTGGTCAGAGCATGCTGGTGAACTCAG CCATTACCCAGCAACATCCACAGATGAAAGGGCCAGTAGGCCAGGCCTTGCCTAGGCCCCAAGCCCCTCCAAGGCTGCAGAGCCTTATGG GAACAGTCCAGCAAGGAGCACAAAGCTGGCAACAGAGGAGCTTGCAGGGCATGCCTGGGAGGACTAGTGGAGAATTGGGACCATTCAACA ATGGCGCCAGCTACCCTCTTCAAGCTGGGCAGCCGAGACTGACCAAGCAGCACTTCCCACAGGGACTGAGCCAGTCAGTCGTGGATGCTA ACACGGGCACAGTGAGGACCCTCAACCCAGCTGCCATGGGTCGGCAGATGATGCCATCGCTCCCGGGGCAGCAAGGCACCAGCCAGGCGA GGCCAATGGTCATGTCTGGCCTGAGCCAGGGAGTCCCAGGCATGCCAGCGTTCAGCCAGCCCCCAGCACAGCAGCAGATACCCAGTGGCA GCTTTGCTCCAAGCAGCCAGAGCCAAGCCTATGAGCGGAATGCCCCTCAGGACGTGTCATACAATTACAGTGGCGACGGAGCTGGGGGTT CCTTCCCTGGCCTCCCGGACGGTGCAGACCTTGTGGACTCCATCATCAAAGGCGGGCCAGGGGACGAGTGGATGCAGGAGCTTGATGAAT TGTTTGGTAACCCCTAATCAAGAGAGGCCCCAAGATCCACAACTCGAGTGGTTAAAGCTTAAAAAGTGAAAAAGAAACAGGATGTTGACC CATCCTTGTTTTTTGTTTTTTTGACCCACGTAAACTGAGCAAAACTGCAGCTGGCTGACAATGGAAGATCCAGGTGCCAATCCACAGCCC CACCAGGCCTCATTTCACCTGATTTTCACACAGCAATCGAGATGAGACGCCATGCAGATCCCGGCTGCGAGAGAGGGAGACACCCGGAGG AGCAGGTGGGAAGATGAAGCCGGCCAGAGCCCCTCTGCCCAGCATGCCCTGTGATCGCCTGGCCCAGCAGGAGCTGCTTCAGCCGAGAGG GACTATTACCCAAGAGAGGTATCCTCAGCCCCTCCTGCCCCAGGTCGGGAGACAGCAGCTTTGGAGACACAAAAGAGACAGAGCCTCAGC CAGGGAGAGTGAGTCCCCCAGAAGAGGCTGGGTGGTTGCACAGGCCAGGTGCACAGGTTGGAAATGCACTGAACTCTGGGTGCCGAGAGA TGTAAGGCTTTGAGACATGCTACTGAATTTGGAGGGCAGGCACGAAGAACAGTGAGATTGTCAAAAGGAGACAACCACAGATCCTACAGG ACTGTCTGTCTCCTGCCCCATGATGACCCTCAGGAATTGCAAAGGCTCTGCTGTCACAAGGAGAGCAGGCTGAGTTTGGAGCAGGGTCCA TCCGGCAGTCCTGGGACGGCTTCCCTCTGCTGGTGCCCCTGGTGGCAGTCCCTCCAGGTGGGGCTGGAGCCTGCTGGCGCCCAATACAAA ACCCATACATCCAGGTGGGTCACATCTACTTCTGGCGGCCGCAGGGCAGGGAAACCCCTACTGGACCCTGTGTGTCTGCCAGCCTGGAGC CTTTGTCTCCAGCCCTGCCTTTATTCCTCCTTGCCTCCACACCAGCCTCCCCTTGCTTCTCCTTACAGACTATCCAAGAAGTGAAGCTTA TGTCTTTAGGGAGCCTTGGGCAGAGTCCACATAAATGCAGGAAGAACTTAGACAATGCCTGAAATGCAAAGGCGACACTGGAGTCTTCTT TCTCTAACGTGTAGCGTTGAATGAATATCTGCCTGGAACCAAGAGGGCTGCTCTGATGTTTGGGAGTCGGTTTTTTGTGAGCCACATCTG ATATTTCTGATATCCCCAGGAAGGAGTGGCCTGGAGGTCACTGGTTCAGGCTCCCTTTGGGCGAAATCCTGGGAGTGATGCTCTAAAAAT CCACCTTTCCCATCATCCCTACTCATCAGAAAGACAAATATAAAATCCCAGAGAGGTGGAGGAGCTAAAAAAGCAATTGCTCCACCTTAC AAATTTGGATAGAAAGGAGATGTAGTTTATTTCATATGGGCAAAGTAGTCCTCTTCCAAAGTCCTGTACAGTTGTTCTCTGCAATTGACG CACATCTGCCCTAAGCGAAATCTGTCAGAAGGAATCAACAAGGCTCCTTGCCTCCCCTCCCAATCCCCCTTTTGGAGGACTTGTGGCTTC GGTGTCGTCCTAAGTGAGAGTGGCGTGTGCTTTTTTCCTGTCCCCTCCTCCCTCCGTGTCCTAGACGCTGGCTGCCTTCTGTGCACTCCC AGGCAGATCACTACGGAAGAGTCGGAGCCTGTGGGGTTGGACTGGCCACACTCAGTCCTGAGAAGGCGAGTTGCCATGGAAAGCTGGGGG CAGAGGTGTTTTTGGAGAGGAGGCGGCAGGCAAACATTGCCTTTGACTTGCTCTCCGCGTACCCGGGGTTGTAGAGCTGCTCAGGAAGGG GCAGGATGTAAGGCCAGAGGTGCCTGGTGGGTGAGAAGCCCAGGCAGGGGCTGGGCGCCCTCTCCGAAGAGGTGGCAGCAGGGTGACCCT GAACTCCCCAAATGGGGAGTGATGCCACTGGGGAAACTGAGTGGATCAAAGAGATGAAACCAAAAAAAAGCAAACAAACAAATGAGAAGA CACAAAACATAATTACCTTTTCCTGAAAGGTACAGGAAATAAATATATAAGCAATGATGAGAAACTGGAGGTGGCTAATGGAAGTGAGAC AGACAGGGGTGGGGGGCTCCATTATCTTTTAAAAGCTTCCTCCAAATGCTCAGTACTGGGACCAACTAATAGGTAGATTTTAATATGGTG GTTTTGTTTTGGTTTTGTTTTTACTACGGTGCTGATGTATATGTAATGTCTAAAAAAAGTTATTTGTACATAAGTTTTTACAATACTGCA GATATCACTGGGTCTACTATCTGTAAAAAATATACATATAAATATATATATACTGTTTGTTTAAAATAGAGTATTTTTATTTCATTCCTT AACTCATCATCACAGCAGTGGTATTGCACTTCAGATGACATCTAATTACTAATTTGTACTGTATGACCTCTGGCAACTTGCTCCATTTTA TTCAGATTTTTCTAGTTTTCTGTTTTTACTTTGTACATTGAGCATTGCTTATTTCCTTTTAAGAAATGTACAGAACGCTGAAATGTAGAA |
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FusionGenePPI for STRN3_MAML3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STRN3 | STK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, TRAF3IP3, PPP2CB, ZRANB1, PPP2R1B, ELAVL1, SLC2A4, APC, PRPF31, LIG4, STK3, STK4, CTNNB1, FKBP15, FMNL1, KIAA1671, NACC1, PARVG, PBK, PSMD13, ZNF219, PCOLCE2, MAGEA1, SNAI3, NR1H3, ZNF444, PPP2R2C, RASSF3, COL4A5, DNAJA2, PGAM5, RUVBL2, NTRK1, XPO1, HSPE1, PON2, TCF12, MAP4K4, PKN3, DYNLL1, TMEM126A, LAMA1, PRDM14, TNFRSF1A, ZNF550, TPTE2, NHSL2, EXOC1, B4GALT4, SPINK2, ACOX2, ZNF331, YPEL1, TRIM25 | MAML3 | MAML1, NOTCH1, NFX1, SUPT5H, RAI1, ZBTB1, SCMH1, ZZZ3, RBPJ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STRN3_MAML3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STRN3_MAML3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MAML3 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | MAML3 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Tgene | MAML3 | C1261473 | Sarcoma | 1 | CTD_human |
| Tgene | MAML3 | C1710096 | Sinonasal undifferentiated carcinoma | 1 | CTD_human |
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