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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36590

FusionGeneSummary for STRIP1_LITAF

check button Fusion gene summary
Fusion gene informationFusion gene name: STRIP1_LITAF
Fusion gene ID: 36590
HgeneTgene
Gene symbol

STRIP1

LITAF

Gene ID

85369

9516

Gene namestriatin interacting protein 1lipopolysaccharide induced TNF factor
SynonymsFAM40A|FAR11APIG7|SIMPLE|TP53I7
Cytomap

1p13.3

16p13.13

Type of geneprotein-codingprotein-coding
Descriptionstriatin-interacting protein 1FAR11 factor arrest 11 homolog Afamily with sequence similarity 40, member Ahomolog of yeast FAR11 protein 1protein FAM40Alipopolysaccharide-induced tumor necrosis factor-alpha factorLPS-induced TNF-alpha factorlipopolysaccharide-induced TNF-alpha factorp53-induced gene 7 proteinsmall integral membrane protein of lysosome/late endosometumor protein p53 inducible protein
Modification date2018051920180522
UniProtAcc

Q5VSL9

Q99732

Ensembl transtripts involved in fusion geneENST00000369796, ENST00000369795, 
ENST00000369794, ENST00000461054, 
ENST00000571688, ENST00000413364, 
ENST00000339430, ENST00000381810, 
ENST00000570904, ENST00000571459, 
ENST00000572255, ENST00000576036, 
ENST00000574763, ENST00000571976, 
ENST00000574703, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 2 X 6=72
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STRIP1 [Title/Abstract] AND LITAF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-31-1951-01ASTRIP1chr1

110581379

+LITAFchr16

11727493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369796ENST00000571688STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000413364STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000339430STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000381810STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000570904STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000571459STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000572255STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000576036STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000574763STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000571976STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369796ENST00000574703STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000571688STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000413364STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000339430STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000381810STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000570904STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000571459STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000572255STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000576036STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000574763STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000571976STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369795ENST00000574703STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000571688STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000413364STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000339430STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000381810STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000570904STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000571459STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000572255STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000576036STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000574763STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000571976STRIP1chr1

110581379

+LITAFchr16

11727493

-
5CDS-intronENST00000369794ENST00000574703STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000571688STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000413364STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000339430STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000381810STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000570904STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000571459STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000572255STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000576036STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000574763STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000571976STRIP1chr1

110581379

+LITAFchr16

11727493

-
intron-intronENST00000461054ENST00000574703STRIP1chr1

110581379

+LITAFchr16

11727493

-

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FusionProtFeatures for STRIP1_LITAF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRIP1

Q5VSL9

LITAF

Q99732

Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the cortical actin filamentdynamics and cell shape. {ECO:0000269|PubMed:21834987}. Plays a role in endosomal protein trafficking and intargeting proteins for lysosomal degradation (PubMed:23166352).Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomaldegradation, and thereby helps downregulate downstream signalingcascades (PubMed:23166352). Helps recruit the ESCRT complexcomponents TSG101, HGS and STAM to cytoplasmic membranes(PubMed:23166352). Probably plays a role in regulating proteindegradation via its interaction with NEDD4 (PubMed:15776429). Mayalso contribute to the regulation of gene expression in thenucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro)and may play a synergistic role with STAT6 in the nucleus inregulating the expression of various cytokines (PubMed:15793005).May regulate the expression of numerous cytokines, such as TNF,CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294,PubMed:15793005). {ECO:0000269|PubMed:15793005,ECO:0000269|PubMed:23166352, ECO:0000303|PubMed:15776429,ECO:0000305|PubMed:10200294}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STRIP1_LITAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STRIP1_LITAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STRIP1STK24, MCC, CTTNBP2, CTTNBP2NL, PPP2R1A, PPP2CA, STRN, STRN3, STK26, STRN4, MOB4, PDCD10, SIKE1, STRIP2, SLMAP, FGFR1OP2, STK25, TRAF3IP3, PPP2CB, ZRANB1, EEF1B2, DDB1, POP1, COLGALT1, KATNAL2, SPTAN1, DDX1, KHSRP, NUP214, RBM4, EEF1G, STK3, STK4, ENO1, SHMT2, MOV10, NXF1, SNAI3, RASSF3, NTRK1, PRDM14, TNFRSF1A, TRPT1, ZNF550, SPINK2, LRRCC1, RGS2, PSMC5, ZNF331, PLP1, NHSL2, ZNF223, YPEL1, RAB29LITAFELAVL1, NEDD4, TSG101, ITCH, ATXN1, STAT6, BAG3, HGS, CALCOCO2, STAM2, UBQLN1, REEP6, NEDD4L, WWP1, WWP2, TOM1, TAB2, R3HDM1, HPCAL4, CYHR1, BCS1L, UBB, PUM2, FGFR2, PTPRD, LRP10, APOB, REEP5, RASSF3, FGFR1, HECW2, CD320, PUM1, BMPR1A, CARS, RNF149, TTC33, ARL8A, ACOX1, SDCBP, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STRIP1_LITAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STRIP1_LITAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLITAFC0270913Charcot-Marie-Tooth disease, Type 1C2CTD_human;ORPHANET;UNIPROT