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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36582

FusionGeneSummary for STRAP_STRAP

check button Fusion gene summary
Fusion gene informationFusion gene name: STRAP_STRAP
Fusion gene ID: 36582
HgeneTgene
Gene symbol

STRAP

STRAP

Gene ID

153443

153443

Gene nameserum response factor binding protein 1serum response factor binding protein 1
SynonymsBUD22|P49|Rlb1|STRAP|p49/STRAPBUD22|P49|Rlb1|STRAP|p49/STRAP
Cytomap

5q23.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionserum response factor-binding protein 1BUD22 homologSRF-dependent transcription regulation-associated proteinserum response factor-binding protein 1BUD22 homologSRF-dependent transcription regulation-associated protein
Modification date2018052320180523
UniProtAcc

Q9Y3F4

Q9Y3F4

Ensembl transtripts involved in fusion geneENST00000538352, ENST00000025399, 
ENST00000419869, 		ENST00000538352, 
ENST00000025399, ENST00000419869, 
Fusion gene scores* DoF score3 X 4 X 2=245 X 6 X 2=60
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/60*10)=0
Context

PubMed: STRAP [Title/Abstract] AND STRAP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU509169STRAPchr12

16056244

-STRAPchr12

16055964

+
ChiTaRS3.1BI862036STRAPchr12

16048392

-STRAPchr12

16050814

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000538352ENST00000538352STRAPchr12

16056244

-STRAPchr12

16055964

+
intron-intronENST00000538352ENST00000025399STRAPchr12

16056244

-STRAPchr12

16055964

+
intron-3UTRENST00000538352ENST00000419869STRAPchr12

16056244

-STRAPchr12

16055964

+
intron-3UTRENST00000025399ENST00000538352STRAPchr12

16056244

-STRAPchr12

16055964

+
intron-intronENST00000025399ENST00000025399STRAPchr12

16056244

-STRAPchr12

16055964

+
intron-3UTRENST00000025399ENST00000419869STRAPchr12

16056244

-STRAPchr12

16055964

+
3UTR-3UTRENST00000419869ENST00000538352STRAPchr12

16056244

-STRAPchr12

16055964

+
3UTR-intronENST00000419869ENST00000025399STRAPchr12

16056244

-STRAPchr12

16055964

+
3UTR-3UTRENST00000419869ENST00000419869STRAPchr12

16056244

-STRAPchr12

16055964

+
In-frameENST00000538352ENST00000538352STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000538352ENST00000025399STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000538352ENST00000419869STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000025399ENST00000538352STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000025399ENST00000025399STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000025399ENST00000419869STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000419869ENST00000538352STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000419869ENST00000025399STRAPchr12

16048392

-STRAPchr12

16050814

+
In-frameENST00000419869ENST00000419869STRAPchr12

16048392

-STRAPchr12

16050814

+

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FusionProtFeatures for STRAP_STRAP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRAP

Q9Y3F4

STRAP

Q9Y3F4

The SMN complex plays a catalyst role in the assembly ofsmall nuclear ribonucleoproteins (snRNPs), the building blocks ofthe spliceosome. Thereby, plays an important role in the splicingof cellular pre-mRNAs. Most spliceosomal snRNPs contain a commonset of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF andSNRPG that assemble in a heptameric protein ring on the Sm site ofthe small nuclear RNA to form the core snRNP. In the cytosol, theSm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped inan inactive 6S pICln-Sm complex by the chaperone CLNS1A thatcontrols the assembly of the core snRNP. Dissociation by the SMNcomplex of CLNS1A from the trapped Sm proteins and their transferto an SMN-Sm complex triggers the assembly of core snRNPs andtheir transport to the nucleus. STRAP plays a role in the cellulardistribution of the SMN complex. Negatively regulates TGF-betasignaling but positively regulates the PDPK1 kinase activity byenhancing its autophosphorylation and by significantly reducingthe association of PDPK1 with 14-3-3 protein.{ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. The SMN complex plays a catalyst role in the assembly ofsmall nuclear ribonucleoproteins (snRNPs), the building blocks ofthe spliceosome. Thereby, plays an important role in the splicingof cellular pre-mRNAs. Most spliceosomal snRNPs contain a commonset of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF andSNRPG that assemble in a heptameric protein ring on the Sm site ofthe small nuclear RNA to form the core snRNP. In the cytosol, theSm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped inan inactive 6S pICln-Sm complex by the chaperone CLNS1A thatcontrols the assembly of the core snRNP. Dissociation by the SMNcomplex of CLNS1A from the trapped Sm proteins and their transferto an SMN-Sm complex triggers the assembly of core snRNPs andtheir transport to the nucleus. STRAP plays a role in the cellulardistribution of the SMN complex. Negatively regulates TGF-betasignaling but positively regulates the PDPK1 kinase activity byenhancing its autophosphorylation and by significantly reducingthe association of PDPK1 with 14-3-3 protein.{ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+510221_262212351RepeatNote=WD 6
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+510263_302212351RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+11012_56-105351RepeatNote=WD 1
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+110141_179-105351RepeatNote=WD 4
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+110180_212-105351RepeatNote=WD 5
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+110221_262-105351RepeatNote=WD 6
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+110263_302-105351RepeatNote=WD 7
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+11057_96-105351RepeatNote=WD 2
HgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+11098_137-105351RepeatNote=WD 3
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+51012_56212351RepeatNote=WD 1
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+510141_179212351RepeatNote=WD 4
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+510180_212212351RepeatNote=WD 5
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+51057_96212351RepeatNote=WD 2
TgeneSTRAPchr12:16048392chr12:16050814ENST00000419869+51098_137212351RepeatNote=WD 3


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FusionGeneSequence for STRAP_STRAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STRAP_STRAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STRAPPBLD, GH1, GSK3B, RNPS1, TGFBR1, TGFBR2, SMAD7, SMAD6, STRAP, SMAD2, SMAD3, NME1, SMN1, HDAC5, AXIN1, NOTCH3, PDPK1, FYTTD1, RPS27A, RPL22, RPL24, NPEPPS, CHEK2, GEMIN2, RNU1-1, RNU2-1, BARD1, ECT2, PAXIP1, TP53BP1, VCAM1, NOS2, HSF1, EP300, EGFR, RN7SL1, FBXO6, ACO1, CAPZA1, CAPZA2, ACADM, SPRTN, HUWE1, MOV10, NXF1, BMI1, ABCE1, HNRNPA1, CTPS1, PLCG1, UBA6, NTRK1, OFD1, XPO1, CSDE1, GEMIN5, GEMIN7, DDX20, LARP4B, SZRD1, RAPH1, GEMIN6, PLBD2, SP1, HDAC1, WWP2, LARP6, ZNFX1, GEMIN8, RPRD2, TSNAX, CDK2AP1, PC, TSN, C11orf68, SMN2, GEMIN4, RPRD1B, LSM14A, SUPT6H, PTPN9, DLD, G3BP1, CCND2, BRCA1STRAPPBLD, GH1, GSK3B, RNPS1, TGFBR1, TGFBR2, SMAD7, SMAD6, STRAP, SMAD2, SMAD3, NME1, SMN1, HDAC5, AXIN1, NOTCH3, PDPK1, FYTTD1, RPS27A, RPL22, RPL24, NPEPPS, CHEK2, GEMIN2, RNU1-1, RNU2-1, BARD1, ECT2, PAXIP1, TP53BP1, VCAM1, NOS2, HSF1, EP300, EGFR, RN7SL1, FBXO6, ACO1, CAPZA1, CAPZA2, ACADM, SPRTN, HUWE1, MOV10, NXF1, BMI1, ABCE1, HNRNPA1, CTPS1, PLCG1, UBA6, NTRK1, OFD1, XPO1, CSDE1, GEMIN5, GEMIN7, DDX20, LARP4B, SZRD1, RAPH1, GEMIN6, PLBD2, SP1, HDAC1, WWP2, LARP6, ZNFX1, GEMIN8, RPRD2, TSNAX, CDK2AP1, PC, TSN, C11orf68, SMN2, GEMIN4, RPRD1B, LSM14A, SUPT6H, PTPN9, DLD, G3BP1, CCND2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STRAP_STRAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STRAP_STRAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTRAPC0009404Colorectal Neoplasms1CTD_human
TgeneSTRAPC0009404Colorectal Neoplasms1CTD_human