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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 36578

FusionGeneSummary for STRADA_GRB2

check button Fusion gene summary
Fusion gene informationFusion gene name: STRADA_GRB2
Fusion gene ID: 36578
HgeneTgene
Gene symbol

STRADA

GRB2

Gene ID

92335

2885

Gene nameSTE20-related kinase adaptor alphagrowth factor receptor bound protein 2
SynonymsLYK5|NY-BR-96|PMSE|STRAD|StlkASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
Cytomap

17q23.3

17q25.1

Type of geneprotein-codingprotein-coding
DescriptionSTE20-related kinase adapter protein alphaSTE20-like pseudokinaseSTRAD alphaprotein kinase LYK5serologically defined breast cancer antigen NY-BR-96growth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ash
Modification date2018052320180527
UniProtAcc

Q7RTN6

P62993

Ensembl transtripts involved in fusion geneENST00000245865, ENST00000375840, 
ENST00000392950, ENST00000336174, 
ENST00000447001, ENST00000582137, 
ENST00000580039, ENST00000579340, 
ENST00000392562, ENST00000316804, 
ENST00000316615, ENST00000392563, 
ENST00000392564, ENST00000578961, 
ENST00000462266, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 4 X 4=96
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STRADA [Title/Abstract] AND GRB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTRADA

GO:0006468

protein phosphorylation

12805220

HgeneSTRADA

GO:0006611

protein export from nucleus

12805220

HgeneSTRADA

GO:0032147

activation of protein kinase activity

12805220


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-V5-A7RE-01ASTRADAchr17

61790766

-GRB2chr17

73328878

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000245865ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000245865ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000245865ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000245865ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000245865ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000245865ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000245865ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000375840ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000375840ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000392950ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000392950ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000336174ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000336174ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000447001ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000447001ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
In-frameENST00000582137ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000582137ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-3CDSENST00000580039ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5UTR-intronENST00000580039ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000392562STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000316804STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000316615STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000392563STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000392564STRADAchr17

61790766

-GRB2chr17

73328878

-
Frame-shitENST00000579340ENST00000578961STRADAchr17

61790766

-GRB2chr17

73328878

-
5CDS-intronENST00000579340ENST00000462266STRADAchr17

61790766

-GRB2chr17

73328878

-

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FusionProtFeatures for STRADA_GRB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STRADA

Q7RTN6

GRB2

P62993

Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STRADA_GRB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_264aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_264aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_223aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGEL

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_223aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGEL

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_264aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_203aa
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLNEECDQNWYKAELNGK
DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVNSRHTSRPSLTLIPRRMESWASAGEILSMSWITQT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_279aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF
LWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_279aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF
LWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_238aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTY

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_238aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTY

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_279aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF
LWVVKFNSLNELVDTHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_218aa
MSFLVSKPERIRTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQVLN
EECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVNSRHTSRPSLTLIPRRMESW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_792nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTT
AGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGAT
GTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTAT
CACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTC
TTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGG

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_792nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTT
AGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGAT
GTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTAT
CACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTC
TTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGG

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_669nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCC
GGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAG
ATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTG
GGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_669nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCC
GGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAG
ATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTG
GGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_792nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTT
AGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGAT
GTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTAT
CACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTC
TTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGG

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_609nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTATTT
GGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTA
GAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAA
GACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTT
AGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAACAGCCGACATACG
TCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACC

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_837nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAG
AGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTC
CTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGG
GACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGG
GGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTAT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_837nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAG
AGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTC
CTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGG
GACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGG
GGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTAT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_714nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAG
CTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATAC
GTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGAC

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_714nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAG
CTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATAC
GTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGAC

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_837nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAG
AGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTC
CTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGG
GACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGG
GGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTAT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_654nt
ATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACAGGAGGTCATG
AGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGG
TACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAAC
GAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCG
TGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAG
AGCGCTCCTGGGGACTTCTCCCTCTCTGTCAACAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGG
GCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_3266nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGC
TTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACG
ATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATT
ATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCC
TCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGT
GGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATT
ATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACA
CCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACC
TATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTG
TCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCT
ATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGG
GCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTC
CAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTC
ACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCC
CGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAA
CCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAA
AAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTC
CTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTT
CAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAG
GTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTT
GCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTAC
AGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGAC
AAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACT
CACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGG
AAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGA
GTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATG
TGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGG
CCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGG
CGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCT
GGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATAT
TTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGGTAGGTAGTGATTAACTGTGA

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_3266nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGC
TTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACG
ATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATT
ATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCC
TCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGT
GGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATT
ATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACA
CCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACC
TATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTG
TCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCT
ATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGG
GCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTC
CAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTC
ACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCC
CGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAA
CCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAA
AAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTC
CTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTT
CAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAG
GTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTT
GCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTAC
AGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGAC
AAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACT
CACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGG
AAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGA
GTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATG
TGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGG
CCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGG
CGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCT
GGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATAT
TTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGGTAGGTAGTGATTAACTGTGA

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_3143nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAG
CCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGC
AGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGC
TGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGT
TTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATAC
AAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTT
GGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTT
CACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATA
GTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGA
AAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCC
AGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGC
ATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG
GTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTG
TGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCG
TGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACT
TTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTT
TTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATT
TTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGA
GGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACC
GGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGG
GGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCA
GCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCC
ATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAG
TGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGA
CCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTT
CCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTC
CCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCC
TTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTA
TTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_3143nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAG
CCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGC
AGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGC
TGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGT
TTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATAC
AAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTT
GGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTT
CACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATA
GTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGA
AAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCC
AGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGC
ATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG
GTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTG
TGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCG
TGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACT
TTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTT
TTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATT
TTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGA
GGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACC
GGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGG
GGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCA
GCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCC
ATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAG
TGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGA
CCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTT
CCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTC
CCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCC
TTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTA
TTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCT

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_3266nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGC
TTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACG
ATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATT
ATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCC
TCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGT
GGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATT
ATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACA
CCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACC
TATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTG
TCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCT
ATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGG
GCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTC
CAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTC
ACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCC
CGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAA
CCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAA
AAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTC
CTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTT
CAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAG
GTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTT
GCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTAC
AGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGAC
AAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACT
CACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGG
AAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGA
GTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATG
TGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGG
CCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGG
CGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCT
GGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATAT
TTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGGTAGGTAGTGATTAACTGTGA

>In-frame_STRADA_ENST00000447001_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_832nt
ATCAGTCCTCCCGGTCGCCCCACTGCGCATGGCACGTTGCGTACTCCCCTCCCAGCAACCGGTCTGGCGGCGGCGCGGCAGTAAAACTGA
GGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACAGTAGGAAC
TCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGCGGTGGGTCTCGGAAAAGTTCATTGTTGAGGGCTTAAGAGATTTGGAACTAT
TTGGAGGCAAAGGATTTGAGGACCTGATGACTGTGAATCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACC
TAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAA
AAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGC
TTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAACAGCCGACATA
CGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGA
CCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTC

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392562_chr17_73328878_-_3229nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCG
AGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGG
GAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGAT
ATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGG
CTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCC
CCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAA
GAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTT
GGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACT
GCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCC
TAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGA
AGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAG
GAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGT
CTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG
GCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGC
ACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCC
ATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGT
TGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTT
TTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTC
CCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCT
TTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGG
CAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGT
TGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCT
CCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGG
CTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGG
CTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAA
GGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCA
CGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTC
CGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCC
CTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTT
GGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316804_chr17_73328878_-_3229nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCG
AGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGG
GAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGAT
ATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGG
CTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCC
CCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAA
GAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTT
GGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACT
GCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCC
TAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGA
AGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAG
GAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGT
CTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG
GCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGC
ACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCC
ATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGT
TGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTT
TTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTC
CCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCT
TTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGG
CAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGT
TGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCT
CCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGG
CTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGG
CTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAA
GGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCA
CGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTC
CGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCC
CTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTT
GGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000316615_chr17_73328878_-_3106nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTC
TTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCA
GCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGA
TAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGT
CTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGC
CTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATT
TAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTT
TCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCA
AGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACA
CACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCA
GACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACC
TGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACC
TAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTG
AGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATT
CCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGT
TTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTT
AAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGG
AGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTT
GGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACA
TCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCT
GGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTG
GGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTG
AGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGAT
GGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACT
TCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGG
GAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGA
GCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTC
GCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAAC
TAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGG

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392563_chr17_73328878_-_3106nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTC
TTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCA
GCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGA
TAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGT
CTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGC
CTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATT
TAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTT
TCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAAGAAACCA
AGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACA
CACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCA
GACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACC
TGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACC
TAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTG
AGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATT
CCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTCCAGTGGGATTATCGAGCATGTTGT
TTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTT
AAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGG
AGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTT
GGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACA
TCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCT
GGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTG
GGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTG
AGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACTGCTGCTCCCCACCCCTACCGAT
GGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACT
TCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGG
GAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGA
GCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTC
GCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAAC
TAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGG

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000392564_chr17_73328878_-_3229nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCG
AGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGG
GAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGAT
ATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGG
CTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACCGGCATGTTTCC
CCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAA
GAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTT
GGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACT
GCTGCTCCTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAGTCC
TAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGAATGACTGAAAGA
AGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAG
GAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGT
CTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGG
GCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGC
ACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCC
ATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGT
TGGCCCTTCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTTTTT
TTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTGTAAATATTTTTC
CCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGCT
TTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGG
CAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGT
TGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCT
CCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGG
CTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGG
CTGTGTTGACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGACCAA
GGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCCAAACCCCTTCCCA
CGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCCCTC
CGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCC
CTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTT
GGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGT

>In-frame_STRADA_ENST00000582137_chr17_61790766_-_GRB2_ENST00000578961_chr17_73328878_-_795nt
AAAACTGAGGAGGCGGAGCCAAGACGGTCGGGGCTGCTTGCTAACTCCAGGAACAGGTTTAAGTTTTTGAAACTGAAGTAGGCCTACACA
GTAGGAACTCATGTCATTTCTTGTAAGTAAACCAGAGCGAATCAGGACCAATGATGCGAGCTCAGAGTCAATAGCATCCTTCTCTAAACA
GGAGGTCATGAGTAGCTTTCTGCCAGAGGGAGGGTGTTACGAGCTGCTCACTGTGATAGGCAAAGGATTTGAGGACCTGATGACTGTGAA
TCTAGCAAGGTACAAACCAACAGGAGAGTACGTGACTGTACGGAGGATTAACCTAGAAGCTTGTTCCAATGAGATGGTAACATTCTTGCA
GGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAA
ACCACATCCGTGGTTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGATGGGGCCTTTCTTATCCG
AGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAACAGCCGACATACGTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGAT
GGAGAGCTGGGCTTCCGCCGGGGAGATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGGCAGACC


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FusionGenePPI for STRADA_GRB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STRADASTK11, CAB39, HSP90AA1, XPO1, FBXL19, SHMT2, CAB39L, PIP4K2A, C5orf24, LBHD1GRB2CSF1R, PRRC2A, EGFR, ERBB2, ERBB3, ERBB4, MED28, BCR, GAB2, CBL, ETV6, LY6G6F, NEU3, SRC, PDE6G, DOCK1, FASLG, SHC1, SOS1, VAV2, VAV3, RACGAP1, IQGAP1, KRT7, KRT8, KRT17, KRT18, PLEC, EPPK1, BCAR1, WAS, MAP4K1, BLNK, IL2RB, SYN1, PDGFRB, KHDRBS1, PTPN6, PTPN11, SYK, CD22, GAB1, IRS1, TNFRSF1A, PTK2, SH3BP2, CD28, TNK2, KIT, SOCS1, PTPRA, CBLB, EPHA2, AXL, DAG1, MAP2, PLCG1, MST1R, ITGA2B, NCKIPSD, NTRK1, PTPN1, JAK2, GRB2, USP8, CSF3R, HTT, MET, LCP2, SNTA1, ABL1, LAT, FLT4, PIK3R1, FRS2, GAB3, VAV1, SH2B2, SH2B1, PRKAR1A, DCTN1, RET, CRK, PTPN22, JAK1, ARHGAP17, SHB, REPS2, OCRL, PDGFRA, PXN, PAG1, TRAT1, INSR, RAPGEF1, KDR, SELL, ADRB2, EPOR, SYNCRIP, ZAP70, IRS4, MUC1, ITK, LAT2, SH2B3, ANXA2, ARHGAP35, RASA1, PTPN12, CRKL, ADAM15, ADAM10, WASL, EPS15, IL6ST, SH3KBP1, EPHB1, MAP3K1, FLT3, RALGPS1, USP6NL, SPRY2, PTPRE, DNM1, HNRNPC, MAPK9, DRD3, CDKN1B, ALOX5, PIK3C2B, GHR, HCLS1, DTX1, LAX1, SOS2, DRD4, PTK2B, SKAP1, TOM1L1, SHKBP1, FGFR3, INPP5D, MICAL1, PLXNB1, OTUD5, STAMBP, ALK, NPM1, BTK, CSN2, DAB2, EP300, HNRNPK, HSPA5, MAP1A, ATP8, ND4, MYH9, MYH11, NCL, NFYB, PIK3R2, RBBP6, SLC1A2, SPTBN1, SS18, UBA52, UBC, WIPF1, MAP4K3, ASAP2, SYNJ2, DLGAP1, ARHGAP32, HELZ, PDCD6IP, HIPK3, DCTN2, TCERG1, KIF3A, MAP4K5, KIAA1549L, ABI3BP, PTPN23, ASAP1, ERRFI1, WDR44, USP53, RIF1, SH2D4A, GAREM, RBM33, MSI2, WIPF2, SH3D19, NAP1L5, STK32C, MYO18A, A2M, AEBP1, AGT, AHSG, ALAS2, STRADB, AMBP, APCS, APOH, SNRNP200, B2M, GPANK1, BPGM, CLU, DNAJA3, DNAJB11, ESD, FABP1, FHOD1, FN1, GC, H1F0, HP, IK, PBXIP1, POLR2A, PRKAB1, RNF10, TF, TFG, TSC2, ENO1, ITIH4, AP4S1, CUTA, POMP, C21orf58, CD164, C21orf91, CFH, COX6A1, ECHS1, FH, NADK, FTL, PRAP1, GSTK1, TCEAL8, POLR1D, RBP4, SHBG, WDR1, IRF5, PPP3CA, GIT1, CDC42, CASP2, ELAVL1, SYNM, AP2A2, DNM2, NCK1, UBASH3B, CUL3, DCUN1D1, LRRK1, INPPL1, ARAP1, KRT85, HSPA8, HSPG2, KRT86, KRT1, KRT81, KRT35, CAD, KRT10, KRT2, HSPA9, KRT83, CCT8, KRT9, KRT33B, HSP90AA1, DNM3, DYNC1H1, TUBB, KRT34, RPS19, HSPA1B, HSP90AB1, SKAP2, CCT4, EEF1A1P5, KRT6A, KRT14, TUBB4B, TUBA1C, KRT16, TCP1, CCT2, ACTB, FAM175B, CCT3, KRT5, KRT15, CLPX, EEF1G, PSMD11, CALM3, HSPA1L, KRT32, DARS, HSPD1, EEF1D, CNOT1, UBR4, AHNAK, CLTC, KRT36, KRT82, MFAP4, PSTPIP2, PSMC2, PSME1, PSMD14, CD2AP, FUS, BRE, KRT19, CTTN, KRT4, VASP, CCT7, KRT73, HNRNPU, BABAM1, HNRNPD, DRG1, IMPDH2, SERBP1, PIK3CA, TUBA4B, BRCC3, DOK3, HIST4H4, GAPDH, RUVBL1, PSMD13, RPS20, ACTL6A, RARS, CCT5, HSD17B4, TSG101, IRS2, PDE4D, SPRY1, SPRY4, VCAM1, ELMO2, WDR6, WDR77, SNX18, NISCH, YWHAZ, STARD10, YWHAE, SH3PXD2B, DOCK4, PEAK1, PIK3CB, SLC25A5, YWHAB, YWHAQ, PPP2R2A, SIRPA, SYNJ1, FGD6, PIK3AP1, KIRREL, YWHAG, GAREML, AGER, WIPF3, PTPN18, SLC25A13, CYFIP2, ARHGEF7, PPP1CA, CSK, PTPRJ, YWHAH, CSRP1, SH3PXD2A, TTYH2, PIK3R3, FLNA, ARHGAP12, RADIL, SH2D5, FAU, NCKAP1, DIAPH1, HGS, CLASP2, TEC, SLC25A6, HUNK, MLLT4, C1orf27, PPP1CC, HDGFRP3, SLAIN2, EPS15L1, IGF2BP1, PPP5C, GJA9, TAB1, ITGA4, BAG3, CKS2, FTH1, COPB1, PHACTR4, SF3B4, VIM, UBA1, PHC2, KPNA2, CTAGE5, PON2, ARHGEF5, CASC3, MLXIPL, WBP11, YLPM1, SHANK3, NKD2, SLX1A, ACTG1, CBR1, AP2A1, AP2B1, AP2M1, AP2S1, HIST1H3A, SMU1, SNRPD2, CD59, ABL2, AES, EPS8, LMO2, REL, TRIM27, TP53BP2, DDX17, IKZF3, ZBTB7B, ABI3, NUTM2F, DPPA4, HOMEZ, NIF3L1, ARHGAP9, LZTS2, LNX1, C1orf94, PNMA5, PRR22, INCA1, DOK1, FKBP2, FABP5, ITCH, ROS1, HEXB, ACAP1, PLEKHS1, AUNIP, UQCC2, CRBN, LMX1A, MYOZ1, PACRGL, PARD6A, PCDHB5, PPARA, RB1, SOCS4, TMEM128, TSPAN2, VCP, WDFY3, DBN1, E2F2, ARL6IP4, OLIG1, WBSCR27, ZMAT1, CLNK, CEP170, FBF1, MCM2, USP12, GFAP, NEFH, HNRNPA2B1, RPS27A, LGALS3BP, MYL12A, MYL12B, S100A8, S100A9, ESRRB, LIME1, KRAS, LTK, SHC2, SHC4, DUSP13, DUSP8, CYLD, VPS37B, NKX2-5, SPATA2L, MVB12A, ZMYM6, VPS28, DOCK5, THEMIS, RAC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STRADA_GRB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STRADA_GRB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTRADAC0025149Medulloblastoma1CTD_human
TgeneGRB2C0036341Schizophrenia2PSYGENET