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Fusion gene ID: 36572 |
FusionGeneSummary for STON2_SEL1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STON2_SEL1L | Fusion gene ID: 36572 | Hgene | Tgene | Gene symbol | STON2 | SEL1L | Gene ID | 85439 | 6400 |
| Gene name | stonin 2 | SEL1L, ERAD E3 ligase adaptor subunit | |
| Synonyms | STN2|STNB|STNB2 | PRO1063|SEL1-LIKE|SEL1L1 | |
| Cytomap | 14q31.1 | 14q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | stonin-2homolog of stoned Bstoned B homolog 2 | protein sel-1 homolog 1Suppressor of lin 12 (sel-1), C. elegans, homolog ofsel-1 suppressor of lin-12-like 1suppressor of lin-12-like protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8WXE9 | Q9UBV2 | |
| Ensembl transtripts involved in fusion gene | ENST00000555447, ENST00000267540, ENST00000556280, | ENST00000336735, ENST00000555824, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 3 X 4 X 2=24 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STON2 [Title/Abstract] AND SEL1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-OX-A56R-01A | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000555447 | ENST00000336735 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| Frame-shift | ENST00000555447 | ENST00000555824 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| In-frame | ENST00000267540 | ENST00000336735 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| In-frame | ENST00000267540 | ENST00000555824 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| intron-3CDS | ENST00000556280 | ENST00000336735 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
| intron-3CDS | ENST00000556280 | ENST00000555824 | STON2 | chr14 | 81837332 | - | SEL1L | chr14 | 81972585 | - |
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FusionProtFeatures for STON2_SEL1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STON2 | SEL1L |
| Adapter protein involved in endocytic machinery.Involved in the synaptic vesicle recycling. May facilitateclathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094,ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. | Plays a role in the endoplasmic reticulum qualitycontrol (ERQC) system also called ER-associated degradation (ERAD)involved in ubiquitin-dependent degradation of misfoldedendoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1stability. Plays a role in LPL maturation and secretion. Requiredfor normal differentiation of the pancreas epithelium, and fornormal exocrine function and survival of pancreatic cells. Mayplay a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6,ECO:0000269|PubMed:16186509}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STON2_SEL1L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000336735_chr14_81972585_-_872aa MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQ PPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT SGQASGADSTALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKI LNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYT FGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDV QAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGV QVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERG RWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGT DVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQL >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000555824_chr14_81972585_-_379aa MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQ PPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT SGQASGADSTALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKI LNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000336735_chr14_81972585_-_2616nt ATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCCTTTCCTGCCCACTCGCAGGGG GGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAACCATGTGGTGGATGGAGGCTCT CAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCCCCACCTGGGAGCCCTGAGCAG CCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGCACATCTCCACCTCATCAGGAA ACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGATGCCCTCTGACTTCTGAGAGC AGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTCATCAATGCTGAGGAGCAGACG AGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTC CTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAA AAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATC CTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAG AGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGC TCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACA TTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGGTTACAGATACTGGGCTGGCATCGGCGTCCTCCAGAGTTGTGAATCT GCCCTGACTCACTATCGTCTTGTTGCCAATCATGTTGCTAGTGATATCTCGCTAACAGGAGGCTCAGTAGTACAGAGAATACGGCTGCCT GATGAAGTGGAAAATCCAGGAATGAACAGTGGAATGCTAGAAGAAGATTTGATTCAATATTACCAGTTCCTAGCTGAAAAAGGTGATGTA CAAGCACAGGTTGGTCTTGGACAACTGCACCTGCACGGAGGGCGTGGAGTAGAACAGAATCATCAGAGAGCATTTGACTACTTCAATTTA GCAGCAAATGCTGGCAATTCACATGCCATGGCCTTTTTGGGAAAGATGTATTCGGAAGGAAGTGACATTGTACCTCAGAGTAATGAGACA GCTCTCCACTACTTTAAGAAAGCTGCTGACATGGGCAACCCAGTTGGACAGAGTGGGCTTGGAATGGCCTACCTCTATGGGAGAGGAGTT CAAGTTAATTATGATCTAGCCCTTAAGTATTTCCAGAAAGCTGCTGAACAAGGCTGGGTGGATGGGCAGCTACAGCTTGGTTCCATGTAC TATAATGGCATTGGAGTCAAGAGAGATTATAAACAGGCCTTGAAGTATTTTAATTTAGCTTCTCAGGGAGGCCATATCTTGGCTTTCTAT AACCTAGCTCAGATGCATGCCAGTGGCACCGGCGTGATGCGATCATGTCACACTGCAGTGGAGTTGTTTAAGAATGTATGTGAACGAGGC CGTTGGTCTGAAAGGCTTATGACTGCCTATAACAGCTATAAAGATGGCGATTACAATGCTGCAGTGATCCAGTACCTCCTCCTGGCTGAA CAGGGCTATGAAGTGGCACAAAGCAATGCAGCCTTTATTCTTGATCAGAGAGAAGCAAGCATTGTAGGTGAGAATGAAACTTATCCCAGA GCTTTGCTACATTGGAACAGGGCCGCCTCTCAAGGCTATACTGTGGCTAGAATTAAGCTCGGAGACTACCATTTCTATGGGTTTGGCACC GATGTAGATTATGAAACTGCATTTATTCATTACCGTCTGGCTTCTGAGCAGCAACACAGTGCACAAGCTATGTTTAATCTGGGATATATG CATGAGAAAGGACTGGGCATTAAACAGGATATTCACCTTGCGAAACGTTTTTATGACATGGCAGCTGAAGCCAGCCCAGATGCACAAGTT CCAGTCTTCCTAGCCCTCTGCAAATTGGGCGTCGTCTATTTCTTGCAGTACATACGGGAAACAAACATTCGAGATATGTTCACCCAACTT GATATGGACCAGCTTTTGGGACCTGAGTGGGACCTTTACCTCATGACCATCATTGCGCTGCTGTTGGGAACAGTCATAGCTTACAGGCAA AGGCAGCACCAAGACATGCCTGCACCCAGGCCTCCAGGGCCACGGCCAGCTCCACCCCAGCAGGAGGGGCCACCAGAGCAGCAGCCACCA >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000555824_chr14_81972585_-_1137nt ATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCCTTTCCTGCCCACTCGCAGGGG GGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAACCATGTGGTGGATGGAGGCTCT CAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCCCCACCTGGGAGCCCTGAGCAG CCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGCACATCTCCACCTCATCAGGAA ACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGATGCCCTCTGACTTCTGAGAGC AGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTCATCAATGCTGAGGAGCAGACG AGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTC CTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAA AAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATC CTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAG AGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGC TCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000336735_chr14_81972585_-_8240nt CAGATTTCTGCCTGGCAGATTAACCAACGGCAAGAGAGGCTGATCTGTCTACATTCTGAGTACTGCCCTTGGCAAGACACCTAGAACAGA CCCTGGACCCAAGTCTACCGTACTACCATACCCCTACTCCAGCCCACCCCAGACAGTATTCTGGGGTTCACCTGAGGTCAGCAGTGTGAA GATGACCAGTGCCTTTTTAGCATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCC TTTCCTGCCCACTCGCAGGGGGGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAAC CATGTGGTGGATGGAGGCTCTCAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCC CCACCTGGGAGCCCTGAGCAGCCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGC ACATCTCCACCTCATCAGGAAACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGA TGCCCTCTGACTTCTGAGAGCAGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTC ATCAATGCTGAGGAGCAGACGAGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCC TGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACC TATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATG TATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATG AACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTT GAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCA AAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGGTTACAGATACTGGGCTGGCATCGGC GTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTTGCCAATCATGTTGCTAGTGATATCTCGCTAACAGGAGGCTCAGTA GTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATGAACAGTGGAATGCTAGAAGAAGATTTGATTCAATATTACCAGTTC CTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAACTGCACCTGCACGGAGGGCGTGGAGTAGAACAGAATCATCAGAGA GCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACATGCCATGGCCTTTTTGGGAAAGATGTATTCGGAAGGAAGTGACATT GTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCTGCTGACATGGGCAACCCAGTTGGACAGAGTGGGCTTGGAATGGCC TACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTTAAGTATTTCCAGAAAGCTGCTGAACAAGGCTGGGTGGATGGGCAG CTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGAGATTATAAACAGGCCTTGAAGTATTTTAATTTAGCTTCTCAGGGA GGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGTGGCACCGGCGTGATGCGATCATGTCACACTGCAGTGGAGTTGTTT AAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACTGCCTATAACAGCTATAAAGATGGCGATTACAATGCTGCAGTGATC CAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGCAATGCAGCCTTTATTCTTGATCAGAGAGAAGCAAGCATTGTAGGT GAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCCGCCTCTCAAGGCTATACTGTGGCTAGAATTAAGCTCGGAGACTAC CATTTCTATGGGTTTGGCACCGATGTAGATTATGAAACTGCATTTATTCATTACCGTCTGGCTTCTGAGCAGCAACACAGTGCACAAGCT ATGTTTAATCTGGGATATATGCATGAGAAAGGACTGGGCATTAAACAGGATATTCACCTTGCGAAACGTTTTTATGACATGGCAGCTGAA GCCAGCCCAGATGCACAAGTTCCAGTCTTCCTAGCCCTCTGCAAATTGGGCGTCGTCTATTTCTTGCAGTACATACGGGAAACAAACATT CGAGATATGTTCACCCAACTTGATATGGACCAGCTTTTGGGACCTGAGTGGGACCTTTACCTCATGACCATCATTGCGCTGCTGTTGGGA ACAGTCATAGCTTACAGGCAAAGGCAGCACCAAGACATGCCTGCACCCAGGCCTCCAGGGCCACGGCCAGCTCCACCCCAGCAGGAGGGG CCACCAGAGCAGCAGCCACCACAGTAATAGGCACTGGGTCCAGCCTTGATCAGTGACAGCGAAGGAAGTTATCTGCTGGGAACACTTGCA TTTGATTTAGGACCTTGGATCAGTGGTCACCTCCCAGAAGAGGCACGGCACAAGGAAGCATTGAATTCCTAAAGCTGCTTAGAATCTGAT GCCTTTATTTTCAGGGATAAGTAACTCTTACCTAAACTGAGCTGAATGTTTGTTTCAGTGCCATATGGAATAACAACTTTCAGTGGCTTT TTTTTTTCTTTTCTGGAAACATATGTGAGACACTCAGAGTAATGTCTACTGTATCCAGCTATCTTTCTTGGATCCTTTTGGTCATTATTT CAGTGTGCATAAGTTCTTAATGTCAACCATCTTTAAGGTATTGTGCATCGACACTAAAAACTGATCAGTGTAAAAAGGAAAACCCAGTTG CAAGTTTAAACGTGTTCGAAAGTCTGAAAATAGAACTTGCCTTTTAAGTTAAAAAAAAAAAAAGCTATCTTGAAAATGTTTTGGAACTGC GATAACTGAGAAACTCTTACCAGTCCACATGCAATTAGACATATTCAGCATATTTGTTATTTTAAAAGGGAGGGTTGGGAGGTTTCTTAT TGGTGATTGTCACACGGTATACCATACTCCTCTCCTTCAAAGAATGAAAGGCCTTGTTAAGGAGTTTTTTGTGAGCTTTACTTCTTTGGA ATGGAATATACTTATGCAAAACCTTGTGAACTGACTCCTTGCACTAACGCGAGTTTGCCCCACCTACTCTGTAATTTGCTTGTTTGTTTT GAATATACAGAGCCTTGATCCAGAAGCCAGAGGATGGACTAAGTGGGAGAAATTAGAAAACAAAACGAACTCTGGTTGGGGTACTACGAT CACAGACACAGACATACTTTTCCTAAAGTTGAAGCATTTGTTCCCAGGATTTATTTTACTTTGCATTTCTTTTTGCACAAAGAACACATC ACCTTCCTGAATTCTTTAAATATGAAATATCATTGCCAGGGTATGGCTTACAGTGACTACTATTATAATACTAAAACTCAGAGAATCAAA GATGGATTAAACTCAGTGGTTGATGAAAGCCAAAACCTGTTTGTACTGTTCTATACTATTCAGGTATCTTTTTATTTCTGATAGTTTTAT ATTATAATAGAAAGCCAGCCACTGCTTAGCTATCATAGTCACCATTTTCTCACTGTTAACATTAGGAAAATCAAGGCTACTATGCTTCAG GATTGTCTGGTTAAATAGTATGGGAAAAAAACTGAAGAGTTTCACATAATTACACACGTGAAATAATTAAAGCTTAAACTGAATTTGTAT TTCATTTTATTGTCAGATGGTGGTGTTCACCAGCCTGTATCTTGTCTGAGACTGCATTCGTATCTGAGCAGGTTTTCTATGCCTACTGAT GTCAGTATGTTTATACTAACCTTCATGCTTTTTTCCCAGAATCCCTCATCTGCCAGAAAACTTGAAAAGTTTATTGCTTGTAGAGTTGTA CTGCTTTGATTTTTGAAGTTGGGGTAGTAGTTAGAACTAGATTTAACTAGTCTATAATGAACATGAAGGCTTTTATATATGAAGTTGTAT ACCTTTTTGTGTTTAGAGAATTATGGGAAACCTGGTAAGCAAAACTTTCCTCCCAGATAATTGCTTCCAAATTCGAAGAGTTAGTCACCA AGAGAGCCATATGTATGAAAGCGTATCTGTGAAAGGTAGGAAACTTACCCCCCCTAAGTGTAATGTTGCTTTAGGCAACTCTTGTAAATA GTGAGACTTGTTTGGTCTCTTACATGTAGAGATTTGAGTGCAGTTGGTACAGTACTTTGGTGTCTCCACCACTGTCCCTTCTCCCCGCTT CAAAATAAGTGTAATCCACGGTAGCAGCCACACTTCCTTTAGAAGGAACTGTTATAATTTATTTAAAAGTTGAAAAACCACCCAAGATGA CTACCAACTTTCACTTTTTTCTTCTGCCATCCACCCTCATTTTTCCTTTAGCAAGATTTTTATATCTAACTTTCCTTCCCTCCATTGAGT ACGTGCTTTGAGAAAACATTTCTTAAAACAGTGTGTGCCACCTAAGGCTGGATGGGAAAGTGCAGTCTTGTTGTTCATATAAAAACACAC TTCTTATTAGTTTACCACTTGCCTTTTTCTATTGTTAATGTTCTGAATTTCCTTTTCTTGGCTTGTTTCTACTTCATTTTACCCTGGGTC ACTTGCTGCCAGCAGTTTGTGAATGGTGTCTTTCAAATAACTTAGTTCTTATGGCTTCACTTAAAGACTGTCTCAAAAATACTTTGCTCT CTTCTTCTTTTTTGTTCATGGGACATGGTACCTAAGCAAATAGGAGTTGGGTTTGGTTTTTCTCCTAAAATAATGCTCAATACTTACCTA ATCAAATGGCATCCATTTGAATAAAATGACAATAACTAAAGCTAGTTAATGTCAGTGACATTAAACTAACTCCAGGATTCAGGAGTTTTA ATGTTAGAATTTAGATTTAACAGATAGAGTGTGGCTTCATTTGTCCATGGTAGCCCATCTCTCCTAAGACCTTTTCTAGTCTGTCTTCCT GCCTTCGAACTTGATGACAGTAAAACCCTGTTTAGTATTCTCTTGTGCATTTGGTTTGTTGGTTAGCCGACTGTCTTGAAACTATTCATT TTGCTTCTAGTTTTATTTTACAGAGGTAGCATTGGTGGGTTTTTTTTTTTTTTTCTGTCTCTGTGTTTGAAGTTTCAGTTTCTGTTTTCT AGGTAAGGCTTATTTTTGATTAGCAGTCAATGGCAAAGAAAAAGTAAATCAAAGATGACTTCTTTTCAAAATGTATTGTTTAGCACTTAA CTCAGATGAATTTATAAATTATTAATCTTGATACTAAGGATTTGTTACTTTTTTGCATATTAGGTTAATTTTTACCTTACATGTGAGAGT CTTACCACTAAGCCATTCTGTCTCTGTACTGTTGGGAAGTTTTGGAAACCCCTGCCAGTGATCTGGTGATGATCTGATGATTTATTTAAA GAGCCGTTGATGCCTCCAGGAAACTTAAGTATTTTATTAATATATATATAGGAATTTTTTTTTATTTTGCTTTGTCTTTCTCTCCCTTCT TTTATCCTCATGTTCATTCTTCAAACCAGTGTTTTGGAAGTATGCATGCAGGCCTATAAATGAAAAACACAATTCTTTATGTGTATAGCA TGTGTATTAATGTCTAACTACATACGCAAAAACTTCCTTTACAGAGGTTCGGACTAACATTTCACATGCACATTTCAAAACAAGATGTGT CATGAAAACAGCCCCTTTACCTGCCAAGACAAGCAGGGCTATATTTCAGTGACAGCTGATATTTGTTTTGAAAGTGAATCTCATAATATA TATATGTATTACACATTATTATGACTAGAAGTATGTAAGAAATGATCAGAACAAAAGAAAATTTCTATTTTCATGCAAATATTTTTCATC AGTCATCACTCTCAAATATAAATTAAAATATAACACTCCTGAATGCCTGAGGCACGATCTGGATTTTAAATGTGTGGTATTCATTGAAAA GAAGCTCTCCACCCACTTGGTATTTCAAGAAAATTTAAAACGATCCCAAGGAAAGATGATTTGTATGTTAAAGTGACTGCACAAGTAAAA GTCCAATGTTGTGTGCATGAAAAGGATTCCTTGGTTATGTGCAGGGAATCATCTCACATGCTGTTTTTCCTATTTGGTTTGAGAAACAGG CTGACACTATTCTCTTTGATTAGAAAATAAACTCATAAAACTCATAATGTTGATATAATCAAGATGTAACCACTATAAATATGTAGAAGA GGAAGTTTTAAAAGACCTTAAGCTGGCATTGTGAAGGAACACCATGGTAGACTCTTTTTGTAAATGTATTTTGTATTTAATGAAATGCAG TATAAAGGTTGGTGAAGTGTAATATAATTGTGTAAACAAATCCTGTTAATAGAGAGATGTACAGAATCGTTTTGTACTGTATCTTGAAAC TTGTGAAATAAAGATTCCACCTCTGGTTATCCTGTATGCTGTAATATACCACAACCAAGCACCTTTCCAGACAGACTTTTTTTAAGCTGA ATGATTCAATTTTTTAATGTTTTTTGGAAATTCAGAAGCTTCTGAAAACATTCACTTGTGGCAATTTGAATTTATCTTTCATTTTAAACT CCTGAAATTCAGATTTTTACAAGTCCAATATTGCCCTAGGGAGAACATGAATTTGCTAAGAAATGTTATCTTTTAAATCTCTGATATCTT TGTCTTGAAGCAGCCTTGATATGTAGTAAGCGTGATTCACTTTAGCCTGATTATAATATTATTTATCTAAAGTTTGTTTATGCATTGCCT TGTCCCAGGAATTTTTTAAGAGGACTTGCAGAGACACGTACCACACAGTAACATTTAGACTAAATATGCTCTGAGTAAAGGAGAAATGAA AAAATATTAAATCAAGAGTGAACATGTACACAAAGTGCAATTGGAAGTGGGCTACAAATTTGGCCCCCAGCTTCCCAGCAGGCAACTCAA AGAGGTAACTGAGGTAAAATGTTCCAGCTCAGAAGCATTGGATCTTGGATAAAAAGCCTACATGATGCAAACTGTGGCAACTGAGATGTC AGATCTCAAGATCTCAAATTGTACTTGTGGGAGCACAGTCAGTGACCCCAGATGACCTTGACTGACCTAAAAGTTGTGGGGGAAGTCGGA TGTCAGAGCCTTAACACCAGCAGGTGACCATCCAACCTGGGGCAATGCCTGCCTGTTCACCACTTAGCCTCTTTCTGGCAAGTCATTAGA ATGTCCTCCATCTTCATTGGCTGCAACTTGATGAGCTACAGCCTCTTTCCTAACTTCCTTTATGATGCTAGTTTAGGTTGGTTATACCAG CTTGGAAGTATGCTTAGATTAAGTTACAGCAGATACACAAATTAGATGCAAGTAAAAAAAATCAGAATTTCTGTAGTAGAAACTACGAAA AATAAAAAGGAAAGTTTTTACTTTTTGGGTATTTTTTTACGAATAAGAAAAAGTGAGCGTTAATCAGTTCAAAAGGAGGTACTGCTGTGT AATGGGCTTTGTACGTTCCTTCTCATGTCACTTACGTCACTACTTCGCCATCAAATTGAACAAGCTTTTAATTAGATCCTGAAAATTCAC TATGCTAGTAGTTTATTGGTAGTATTATATTTTGAGTAGAACTCTGATTTTCCCTAGAGGCCAAATTCTTTTTATCTGGGTTAATTTCTT TTAAACATAACAATGTTAATGCTGAATTGTATATTAAATCCCATTTCTAAAAACCACACAATTTTTTCTCATGTAAGTTGAGTGGAATGT >In-frame_STON2_ENST00000267540_chr14_81837332_-_SEL1L_ENST00000555824_chr14_81972585_-_1974nt CAGATTTCTGCCTGGCAGATTAACCAACGGCAAGAGAGGCTGATCTGTCTACATTCTGAGTACTGCCCTTGGCAAGACACCTAGAACAGA CCCTGGACCCAAGTCTACCGTACTACCATACCCCTACTCCAGCCCACCCCAGACAGTATTCTGGGGTTCACCTGAGGTCAGCAGTGTGAA GATGACCAGTGCCTTTTTAGCATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCC TTTCCTGCCCACTCGCAGGGGGGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAAC CATGTGGTGGATGGAGGCTCTCAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCC CCACCTGGGAGCCCTGAGCAGCCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGC ACATCTCCACCTCATCAGGAAACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGA TGCCCTCTGACTTCTGAGAGCAGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTC ATCAATGCTGAGGAGCAGACGAGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCC TGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACC TATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATG TATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATG AACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTT GAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCA AAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGTAAGTAGACTTTAGTGGAAGGCTAAT AATATTAACATCAGAAGAATTTGTGGTTTATAGCGGCCACAACTTTTTCAGCTTTCATGATCCAGATTTGCTTGTATTAAGACCAAATAT TCAGTTGAACTTCCTTCAAATTCTTGTTAATGGATATAACACATGGAATCTACATGTAAATGAAAGTTGGTGGAGTCCACAATTTTTCTT TAAAATGATTAGTTTGGCTGATTGCCCCTAAAAAGAGAGATCTGATAAATGGCTCTTTTTAAATTTTCTCTGAGTTGGAATTGTCAGAAT CATTTTTTACATTAGATTATCATAATTTTAAAAATTTTTCTTTAGTTTTTCAAAATTTTGTAAATGGTGGCTATAGAAAAACAACATGAA ATATTATACAATATTTTGCAACAATGCCCTAAGAATTGTTAAAATTCATGGAGTTATTTGTGCAGAATGACTCCAGAGAGCTCTACTTTC TGTTTTTTACTTTTCATGATTGGCTGTCTTCCCATTTATTCTGGTCATTTATTGCTAGTGACACTGTGCCTGCTTCCAGTAGTCTCATTT |
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FusionGenePPI for STON2_SEL1L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STON2 | EPS15L1, EPS15, ITSN1, SYT2, SYT1, AP2M1, TOR1A, COPS4, ABL1, VCAM1, FN1, ITGA4, SLC25A41, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, SYNPO, RACGAP1, LIMA1, GTSE1, ANLN, MYO19, MYO18A, AP2S1, LSR, CLINT1 | SEL1L | IGHM, TRA, DERL2, SYVN1, DERL1, EDEM1, FOXRED2, RPN1, UNC93B1, FAM8A1, SARAF, OS9, AUP1, UBXN4, FAF2, UBE2J1, ERN1, ERLEC1, FLOT1, MYH9, SYNJ2BP, BSG, CLN5, EGFR, RPL6, FBXO6, USP19, HEY2, HEY1, SHH, ITGB1, ITGA5, ITGB4, TMEM129, HYOU1, NTRK1, TCTN1, HSP90B1, METTL3, AMFR, EDEM2, EDEM3, HSPA5, ACP5, AMIGO3, SLAMF1, TMEM5, CHST12, CPA5, TPSB2, SMPD1, PSG8, ZPBP2, PTPRE, PTPRO, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STON2_SEL1L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STON2_SEL1L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STON2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | STON2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | STON2 | C1842605 | SCHIZOPHRENIA 11 | 1 | PSYGENET |
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