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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36554

FusionGeneSummary for STMN1_CSMD2

check button Fusion gene summary
Fusion gene informationFusion gene name: STMN1_CSMD2
Fusion gene ID: 36554
HgeneTgene
Gene symbol

STMN1

CSMD2

Gene ID

3925

114784

Gene namestathmin 1CUB and Sushi multiple domains 2
SynonymsC1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMNdJ1007G16.1|dJ1007G16.2|dJ947L8.1
Cytomap

1p36.11

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionstathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215CUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2
Modification date2018052320180403
UniProtAcc

P16949

Q7Z408

Ensembl transtripts involved in fusion geneENST00000426559, ENST00000455785, 
ENST00000399728, ENST00000465604, 
ENST00000357865, ENST00000374291, 
ENST00000373381, ENST00000373380, 
ENST00000373377, ENST00000373388, 
ENST00000489419, ENST00000338325, 
Fusion gene scores* DoF score3 X 3 X 1=97 X 7 X 6=294
# samples 37
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STMN1 [Title/Abstract] AND CSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTMN1

GO:0007019

microtubule depolymerization

9880330

HgeneSTMN1

GO:0007052

mitotic spindle organization

9271428


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M85468STMN1chr1

26227548

-CSMD2chr1

34376250

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000426559ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000426559ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000426559ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000426559ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000426559ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000426559ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000455785ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000399728ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000465604ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000357865ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000373381STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000373380STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000373377STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000373388STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000489419STMN1chr1

26227548

-CSMD2chr1

34376250

-
intron-intronENST00000374291ENST00000338325STMN1chr1

26227548

-CSMD2chr1

34376250

-

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FusionProtFeatures for STMN1_CSMD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STMN1

P16949

CSMD2

Q7Z408

Involved in the regulation of the microtubule (MT)filament system by destabilizing microtubules. Prevents assemblyand promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.Involved in the control of the learned and innate fear (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STMN1_CSMD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STMN1_CSMD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STMN1_CSMD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STMN1_CSMD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTMN1C0011570Mental Depression3PSYGENET
HgeneSTMN1C0011581Depressive disorder3PSYGENET
HgeneSTMN1C0017638Glioma1CTD_human
HgeneSTMN1C0024667Animal Mammary Neoplasms1CTD_human
HgeneSTMN1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneSTMN1C0033578Prostatic Neoplasms1CTD_human
HgeneSTMN1C1458155Mammary Neoplasms1CTD_human
TgeneCSMD2C0011570Mental Depression1PSYGENET
TgeneCSMD2C0011581Depressive disorder1PSYGENET
TgeneCSMD2C0036341Schizophrenia1PSYGENET