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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36538

FusionGeneSummary for STK3_OXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: STK3_OXR1
Fusion gene ID: 36538
HgeneTgene
Gene symbol

STK3

OXR1

Gene ID

8428

55074

Gene nameserine/threonine kinase 24oxidation resistance 1
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3Nbla00307|TLDC3
Cytomap

13q32.2

8q23.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3oxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307
Modification date2018052320180519
UniProtAcc

Q13188

Q8N573

Ensembl transtripts involved in fusion geneENST00000419617, ENST00000523601, 
ENST00000521768, 		ENST00000445937, 
ENST00000531443, ENST00000517566, 
ENST00000452423, ENST00000442977, 
ENST00000521963, ENST00000312046, 
ENST00000449762, ENST00000297447, 
ENST00000521592, ENST00000497705, 
Fusion gene scores* DoF score15 X 8 X 8=96011 X 10 X 4=440
# samples 1312
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/440*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STK3 [Title/Abstract] AND OXR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK3

GO:0006468

protein phosphorylation

19604147

HgeneSTK3

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK3

GO:0046777

protein autophosphorylation

17046825|17657516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA392482STK3chr8

99837743

-OXR1chr8

107691436

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000419617ENST00000445937STK3chr8

99837743

-OXR1chr8

107691436

+
Frame-shiftENST00000419617ENST00000531443STK3chr8

99837743

-OXR1chr8

107691436

+
Frame-shiftENST00000419617ENST00000517566STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-5UTRENST00000419617ENST00000452423STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-5UTRENST00000419617ENST00000442977STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000521963STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000312046STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000449762STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000297447STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000521592STK3chr8

99837743

-OXR1chr8

107691436

+
5CDS-intronENST00000419617ENST00000497705STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000523601ENST00000445937STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000523601ENST00000531443STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000523601ENST00000517566STK3chr8

99837743

-OXR1chr8

107691436

+
intron-5UTRENST00000523601ENST00000452423STK3chr8

99837743

-OXR1chr8

107691436

+
intron-5UTRENST00000523601ENST00000442977STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000521963STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000312046STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000449762STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000297447STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000521592STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000523601ENST00000497705STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000521768ENST00000445937STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000521768ENST00000531443STK3chr8

99837743

-OXR1chr8

107691436

+
intron-3CDSENST00000521768ENST00000517566STK3chr8

99837743

-OXR1chr8

107691436

+
intron-5UTRENST00000521768ENST00000452423STK3chr8

99837743

-OXR1chr8

107691436

+
intron-5UTRENST00000521768ENST00000442977STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000521963STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000312046STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000449762STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000297447STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000521592STK3chr8

99837743

-OXR1chr8

107691436

+
intron-intronENST00000521768ENST00000497705STK3chr8

99837743

-OXR1chr8

107691436

+

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FusionProtFeatures for STK3_OXR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK3

Q13188

OXR1

Q8N573

Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation.Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 andplays a role in centrosome disjunction by regulating thelocalization of NEK2 to centrosome, and its ability tophosphorylate CROCC and CEP250. In conjunction with SAV1,activates the transcriptional activity of ESR1 through themodulation of its phosphorylation. Positively regulates RAF1activation via suppression of the inhibitory phosphorylation ofRAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2.Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively withMOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10,ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043,ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395,ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796,ECO:0000269|PubMed:8816758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK3_OXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK3_OXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK3CNKSR1, MAP1LC3A, MAP1LC3B, RASSF5, STK4, SAV1, ATG4B, PLK1, CACYBP, RASSF2, FREM1, KHSRP, DDAH2, PHAX, QARS, MPP1, GBP2, LATS1, RASSF6, MOB4, NRD1, MOB1A, RASSF1, RAF1, MBP, MOB1B, LATS2, PTPN14, LRRK2, EIF4EBP1, TAZ, STK3, AKT1, ORM2, CPNE1, PEX19, ZC3H7A, HSPE1, SULT2A1, SLMAP, CTTNBP2NL, RASSF3, AURKB, ERLIN2, STRIP1, FGFR1OP2, KIF2C, MAP1S, PRKRIR, RAE1, RASSF4, RUNDC3B, STRN, STRN3, STRN4, TSPYL1, YWHAB, CSNK1E, NEB, MAP1B, CDK3, DST, ACACA, VAPA, FBXW11, GAD1, TRAF1, TFPT, GMCL1, FAM9B, BTRC, ADCYAP1, MRPL40, NSUN5, IFI16, FGFR1OP, CEP128, XPO1, C21orf59, CENPO, CASP3, MTMR7, KIF2B, ZNF133, VAPB, ZIM2, ZNF420, ZNF695, SKP2, KIF3B, CDK1OXR1LIG4, GTF2E1, NMI, RPL24, TOLLIP, VPS35, KEAP1, MYO1C, IQGAP1, DUSP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK3_OXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK3_OXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource