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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36537

FusionGeneSummary for STK3_MRPL48

check button Fusion gene summary
Fusion gene informationFusion gene name: STK3_MRPL48
Fusion gene ID: 36537
HgeneTgene
Gene symbol

STK3

MRPL48

Gene ID

8428

51642

Gene nameserine/threonine kinase 24mitochondrial ribosomal protein L48
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3CGI-118|HSPC290|L48MT|MRP-L48
Cytomap

13q32.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 339S ribosomal protein L48, mitochondrialmitochondrial large ribosomal subunit protein mL48
Modification date2018052320180523
UniProtAcc

Q13188

Q96GC5

Ensembl transtripts involved in fusion geneENST00000419617, ENST00000523601, 
ENST00000521768, 
ENST00000310614, 
ENST00000535529, ENST00000411840, 
ENST00000398483, ENST00000542303, 
ENST00000314282, 
Fusion gene scores* DoF score15 X 8 X 8=9606 X 3 X 6=108
# samples 136
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STK3 [Title/Abstract] AND MRPL48 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK3

GO:0006468

protein phosphorylation

19604147

HgeneSTK3

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK3

GO:0046777

protein autophosphorylation

17046825|17657516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A1A6-01ASTK3chr8

99837743

-MRPL48chr11

73516072

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000419617ENST00000310614STK3chr8

99837743

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000419617ENST00000535529STK3chr8

99837743

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000419617ENST00000411840STK3chr8

99837743

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000419617ENST00000398483STK3chr8

99837743

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000419617ENST00000542303STK3chr8

99837743

-MRPL48chr11

73516072

+
5CDS-intronENST00000419617ENST00000314282STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-3CDSENST00000523601ENST00000310614STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000523601ENST00000535529STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000523601ENST00000411840STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000523601ENST00000398483STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000523601ENST00000542303STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-intronENST00000523601ENST00000314282STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-3CDSENST00000521768ENST00000310614STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000521768ENST00000535529STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000521768ENST00000411840STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000521768ENST00000398483STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-5UTRENST00000521768ENST00000542303STK3chr8

99837743

-MRPL48chr11

73516072

+
intron-intronENST00000521768ENST00000314282STK3chr8

99837743

-MRPL48chr11

73516072

+

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FusionProtFeatures for STK3_MRPL48


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK3

Q13188

MRPL48

Q96GC5

Stress-activated, pro-apoptotic kinase which, followingcaspase-cleavage, enters the nucleus and induces chromatincondensation followed by internucleosomal DNA fragmentation. Keycomponent of the Hippo signaling pathway which plays a pivotalrole in organ size control and tumor suppression by restrictingproliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, incomplex with its regulatory protein SAV1, phosphorylates andactivates LATS1/2 in complex with its regulatory protein MOB1,which in turn phosphorylates and inactivates YAP1 oncoprotein andWWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits itstranslocation into the nucleus to regulate cellular genesimportant for cell proliferation, cell death, and cell migration.STK3/MST2 and STK4/MST1 are required to repress proliferation ofmature hepatocytes, to prevent activation of facultative adultliver stem cells (oval cells), and to inhibit tumor formation.Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 andplays a role in centrosome disjunction by regulating thelocalization of NEK2 to centrosome, and its ability tophosphorylate CROCC and CEP250. In conjunction with SAV1,activates the transcriptional activity of ESR1 through themodulation of its phosphorylation. Positively regulates RAF1activation via suppression of the inhibitory phosphorylation ofRAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2.Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively withMOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10,ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133,ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890,ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043,ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395,ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796,ECO:0000269|PubMed:8816758}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMRPL48chr8:99837743chr11:73516072ENST00000310614+0869_747213Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-111287_3288492Coiled coilOntology_term=ECO:0000255
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-111442_4758492Coiled coilOntology_term=ECO:0000255
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-111308_3148492Compositional biasNote=Poly-Glu
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-111370_3758492Compositional biasNote=Poly-Glu
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-11127_2788492DomainProtein kinase
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-111437_4848492DomainSARAH
HgeneSTK3chr8:99837743chr11:73516072ENST00000419617-11133_418492Nucleotide bindingATP


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FusionGeneSequence for STK3_MRPL48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STK3_ENST00000419617_chr8_99837743_-_MRPL48_ENST00000310614_chr11_73516072_+_214aa
MEQPPAPKRCCAXGTIPFLSKPFLSXGLELQERSPSILXVEFYXVSVGPTRQSPPTALESTSTXLKQKSPRRRREKWKXEPLIWGQIMNM
GFXIFIXLHMIXPWQRVMPSMFTTSATLSPLKSRKVMQCQPKPXKCCSCRTKAAKCSWTQCLPPMSEWFRSAVXVLRLQKFSWKXSKAVF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STK3_ENST00000419617_chr8_99837743_-_MRPL48_ENST00000310614_chr11_73516072_+_644nt
ATGGAGCAGCCGCCGGCGCCTAAGAGGTGCTGTGCCTGAGGAACAATACCATTTTTAAGCAAGCCTTTTCTCTCTTAAGGTTTAGAACTT
CAGGAGAGAAGCCCATCTATTCTGTAGGTGGAATTCTACTAAGTATCAGTCGGCCCTACAAGACAAAGCCCACCCACGGCATTGGAAAGT
ACAAGCACTTAATTAAAGCAGAAGAGCCCAAGAAGAAGAAGGGAAAAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATG
GGGTTTTAAATATTCATCTGACTGCATATGATATGACCCTGGCAGAGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCA
TTAAAGTCGAGGAAAGTTATGCAATGCCAACCAAAACCATAGAAGTGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAG
TGCTTACCACCCATGAGCGAGTGGTTCAGATCAGCGGTTTGAGTGCTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTC
CTGAAGGAGTCAGACTGTCAGTGAAGGAGCACACTGAAGAAGACTTCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_STK3_ENST00000419617_chr8_99837743_-_MRPL48_ENST00000310614_chr11_73516072_+_1026nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGGTGCTGTGCCTGA
GGAACAATACCATTTTTAAGCAAGCCTTTTCTCTCTTAAGGTTTAGAACTTCAGGAGAGAAGCCCATCTATTCTGTAGGTGGAATTCTAC
TAAGTATCAGTCGGCCCTACAAGACAAAGCCCACCCACGGCATTGGAAAGTACAAGCACTTAATTAAAGCAGAAGAGCCCAAGAAGAAGA
AGGGAAAAGTGGAAGTGAGAGCCATTAATTTGGGGACAGATTATGAATATGGGGTTTTAAATATTCATCTGACTGCATATGATATGACCC
TGGCAGAGAGTTATGCCCAGTATGTTCACAACCTCTGCAACTCTCTCTCCATTAAAGTCGAGGAAAGTTATGCAATGCCAACCAAAACCA
TAGAAGTGTTGCAGTTGCAGGACCAAGGCAGCAAAATGCTCCTGGACTCAGTGCTTACCACCCATGAGCGAGTGGTTCAGATCAGCGGTT
TGAGTGCTACGTTTGCAGAAATTTTCTTGGAAATAATCCAAAGCAGTCTTCCTGAAGGAGTCAGACTGTCAGTGAAGGAGCACACTGAAG
AAGACTTCAAGGGACGATTCAAAGCTCGACCAGAACTGGAAGAACTGTTGGCCAAGTTGAAGTAGCTACTGTAGACCCTTTCATGCCAGC
AGTGGTCATATTGAGTGCCAAAGAGAAGAGCTTACTGGGTAGTTAGAGTTCATCAGGAGACCCAACCCTTAGATTTCATAAGTACCCATT
CCCATAGCCAGTAATGTCCTCACTCCTCTGTGGCTTGGCTGTACTTGCCATTTCTTACCACTTACCTATGAGGTAATGCTTGTTATCTTC


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FusionGenePPI for STK3_MRPL48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK3CNKSR1, MAP1LC3A, MAP1LC3B, RASSF5, STK4, SAV1, ATG4B, PLK1, CACYBP, RASSF2, FREM1, KHSRP, DDAH2, PHAX, QARS, MPP1, GBP2, LATS1, RASSF6, MOB4, NRD1, MOB1A, RASSF1, RAF1, MBP, MOB1B, LATS2, PTPN14, LRRK2, EIF4EBP1, TAZ, STK3, AKT1, ORM2, CPNE1, PEX19, ZC3H7A, HSPE1, SULT2A1, SLMAP, CTTNBP2NL, RASSF3, AURKB, ERLIN2, STRIP1, FGFR1OP2, KIF2C, MAP1S, PRKRIR, RAE1, RASSF4, RUNDC3B, STRN, STRN3, STRN4, TSPYL1, YWHAB, CSNK1E, NEB, MAP1B, CDK3, DST, ACACA, VAPA, FBXW11, GAD1, TRAF1, TFPT, GMCL1, FAM9B, BTRC, ADCYAP1, MRPL40, NSUN5, IFI16, FGFR1OP, CEP128, XPO1, C21orf59, CENPO, CASP3, MTMR7, KIF2B, ZNF133, VAPB, ZIM2, ZNF420, ZNF695, SKP2, KIF3B, CDK1MRPL48OXA1L, ICT1, APP, HNRNPU, EXOSC2, LSM8, TARDBP, GRSF1, RNF2, BTRC, RPL13, NIFK, MRPL46, MRPL4, MRPL39, MRPS30, MRPL47, HNRNPA1, MRPL9, MRPL55, SDHB, CRK, RPL10, AP4M1, EXOSC4, MRPL50, CDC14B, MRPL10, MRPL41, RPL18, MRPL12, MRPL42, MRPL35


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK3_MRPL48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK3_MRPL48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource