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Fusion gene ID: 36519 |
FusionGeneSummary for STK38_GMDS |
Fusion gene summary |
Fusion gene information | Fusion gene name: STK38_GMDS | Fusion gene ID: 36519 | Hgene | Tgene | Gene symbol | STK38 | GMDS | Gene ID | 11329 | 2762 |
Gene name | serine/threonine kinase 38 | GDP-mannose 4,6-dehydratase | |
Synonyms | NDR|NDR1 | GMD|SDR3E1 | |
Cytomap | 6p21.31 | 6p25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 38NDR1 protein kinaseNdr Ser/Thr kinase-like proteinnuclear Dbf2-related kinase 1 | GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15208 | O60547 | |
Ensembl transtripts involved in fusion gene | ENST00000229812, | ENST00000530927, ENST00000380815, ENST00000467288, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 8 X 5 X 6=240 |
# samples | 5 | 8 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: STK38 [Title/Abstract] AND GMDS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STK38 | GO:0006464 | cellular protein modification process | 7761441 |
Hgene | STK38 | GO:0006468 | protein phosphorylation | 12493777 |
Hgene | STK38 | GO:0035556 | intracellular signal transduction | 12493777 |
Hgene | STK38 | GO:0043407 | negative regulation of MAP kinase activity | 17906693 |
Tgene | GMDS | GO:0019673 | GDP-mannose metabolic process | 9525924 |
Tgene | GMDS | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | 9525924 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-A5-A7WK-01A | STK38 | chr6 | 36467650 | - | GMDS | chr6 | 1742820 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000229812 | ENST00000530927 | STK38 | chr6 | 36467650 | - | GMDS | chr6 | 1742820 | - |
In-frame | ENST00000229812 | ENST00000380815 | STK38 | chr6 | 36467650 | - | GMDS | chr6 | 1742820 | - |
5CDS-intron | ENST00000229812 | ENST00000467288 | STK38 | chr6 | 36467650 | - | GMDS | chr6 | 1742820 | - |
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FusionProtFeatures for STK38_GMDS |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
STK38 | GMDS |
Negative regulator of MAP3K1/2 signaling. ConvertsMAP3K2 from its phosphorylated form to its non-phosphorylated formand inhibits autophosphorylation of MAP3K2.{ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186,ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:7761441}. | Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | STK38 | chr6:36467650 | chr6:1742820 | ENST00000229812 | - | 10 | 14 | 95_103 | 317 | 466 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >STK38 | chr6:36467650 | chr6:1742820 | ENST00000229812 | - | 10 | 14 | 383_455 | 317 | 466 | Domain | Note=AGC-kinase C-terminal |
Hgene | >STK38 | chr6:36467650 | chr6:1742820 | ENST00000229812 | - | 10 | 14 | 89_382 | 317 | 466 | Domain | Protein kinase |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000380815 | - | 6 | 11 | 108_112 | 257 | 373 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000380815 | - | 6 | 11 | 30_35 | 257 | 373 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000380815 | - | 6 | 11 | 55_58 | 257 | 373 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000380815 | - | 6 | 11 | 86_87 | 257 | 373 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000530927 | - | 6 | 11 | 108_112 | 227 | 343 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000530927 | - | 6 | 11 | 30_35 | 227 | 343 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000530927 | - | 6 | 11 | 55_58 | 227 | 343 | Nucleotide binding | NADP |
Tgene | GMDS | chr6:36467650 | chr6:1742820 | ENST00000530927 | - | 6 | 11 | 86_87 | 227 | 343 | Nucleotide binding | NADP |
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FusionGeneSequence for STK38_GMDS |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000530927_chr6_1742820_-_433aa MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFE SLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAET WKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYVVDVAEXXAGGLRYSYWGGPXCPGICREIILAHWKNHCVGR >In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000380815_chr6_1742820_-_433aa MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFE SLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAET WKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYVVDVAEXXAGGLRYSYWGGPXCPGICREIILAHWKNHCVGR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000530927_chr6_1742820_-_1300nt ATGGCAATGACAGGCTCAACACCTTGCTCATCCATGAGTAACCACACAAAGGAAAGGGTGACAATGACCAAAGTGACACTGGAGAATTTT TATAGCAACCTTATCGCTCAACATGAAGAACGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGAAGGCCTAAAAGATGAG GAGAAACGACTCCGGAGATCAGCACATGCTCGGAAGGAAACAGAGTTTCTTCGTTTGAAGAGAACAAGACTTGGATTGGAAGATTTTGAG TCCTTAAAAGTAATAGGCAGAGGAGCATTTGGTGAGGTACGGCTTGTTCAGAAGAAAGATACGGGACATGTGTATGCAATGAAAATACTC CGTAAAGCAGATATGCTTGAAAAAGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATTCTAGTGGAGGCAGACAGTTTGTGGGTTGTG AAAATGTTCTATAGTTTTCAGGATAAGCTAAACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGATGACCTTGTTGATGAAA AAAGACACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAAACAGTATTAGCCATAGACTCTATTCACCAACTTGGATTCATCCAC AGAGACATCAAACCAGACAACCTTCTTTTGGACAGCAAGGGCCATGTGAAACTTTCTGACTTTGGTCTTTGCACAGGACTGAAAAAAGCA CATAGGACAGAATTTTATAGGAATCTGAACCACAGCCTCCCCAGTGATTTCACTTTCCAGAACATGAATTCCAAAAGGAAAGCAGAAACC TGGAAAAGAAATAGACGTCAGCTAGCCTTCTCCACAGTAGGCACTCCTGACTACATTGCTCCTGAGGTGTTCATGCAGACCGGGTACAAC AAGCTCTGTGATTGGTGGTCGCTTGGGGTGATCATGTATGAGATGCTCATCGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGA CTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGG AAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGA CTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCA >In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000380815_chr6_1742820_-_1300nt ATGGCAATGACAGGCTCAACACCTTGCTCATCCATGAGTAACCACACAAAGGAAAGGGTGACAATGACCAAAGTGACACTGGAGAATTTT TATAGCAACCTTATCGCTCAACATGAAGAACGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGAAGGCCTAAAAGATGAG GAGAAACGACTCCGGAGATCAGCACATGCTCGGAAGGAAACAGAGTTTCTTCGTTTGAAGAGAACAAGACTTGGATTGGAAGATTTTGAG TCCTTAAAAGTAATAGGCAGAGGAGCATTTGGTGAGGTACGGCTTGTTCAGAAGAAAGATACGGGACATGTGTATGCAATGAAAATACTC CGTAAAGCAGATATGCTTGAAAAAGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATTCTAGTGGAGGCAGACAGTTTGTGGGTTGTG AAAATGTTCTATAGTTTTCAGGATAAGCTAAACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGATGACCTTGTTGATGAAA AAAGACACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAAACAGTATTAGCCATAGACTCTATTCACCAACTTGGATTCATCCAC AGAGACATCAAACCAGACAACCTTCTTTTGGACAGCAAGGGCCATGTGAAACTTTCTGACTTTGGTCTTTGCACAGGACTGAAAAAAGCA CATAGGACAGAATTTTATAGGAATCTGAACCACAGCCTCCCCAGTGATTTCACTTTCCAGAACATGAATTCCAAAAGGAAAGCAGAAACC TGGAAAAGAAATAGACGTCAGCTAGCCTTCTCCACAGTAGGCACTCCTGACTACATTGCTCCTGAGGTGTTCATGCAGACCGGGTACAAC AAGCTCTGTGATTGGTGGTCGCTTGGGGTGATCATGTATGAGATGCTCATCGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGA CTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGG AAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGA CTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000530927_chr6_1742820_-_1949nt CTCGGCCCCGGGCTGCCGCGCCAGCCCGTCTCCGCGGCGGGGGACCGGGCTGCCTTGGCCCCTCAGCGCTCGCGTCTTTTCCGGCAGTTG GAACGCTTCCTGTTGTCCTCACCCGTAACCGCCTGTTGCCCCCTGTCTCAGAGTCCCTCACGCGTCCCCTCCCGTCTTTGGCTCGTTGGC TGCCGCCGCCGGGGCTTCGCCAGCCTTCAAGTCGAGACTACTGGCCGAAGGGGCGTCTGCGGCTCTCCGCCGTCCCCAGCCCTGCCTCTC CCTGGGCTCTGCAGCCATGGCAATGACAGGCTCAACACCTTGCTCATCCATGAGTAACCACACAAAGGAAAGGGTGACAATGACCAAAGT GACACTGGAGAATTTTTATAGCAACCTTATCGCTCAACATGAAGAACGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGA AGGCCTAAAAGATGAGGAGAAACGACTCCGGAGATCAGCACATGCTCGGAAGGAAACAGAGTTTCTTCGTTTGAAGAGAACAAGACTTGG ATTGGAAGATTTTGAGTCCTTAAAAGTAATAGGCAGAGGAGCATTTGGTGAGGTACGGCTTGTTCAGAAGAAAGATACGGGACATGTGTA TGCAATGAAAATACTCCGTAAAGCAGATATGCTTGAAAAAGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATTCTAGTGGAGGCAGA CAGTTTGTGGGTTGTGAAAATGTTCTATAGTTTTCAGGATAAGCTAAACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGAT GACCTTGTTGATGAAAAAAGACACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAAACAGTATTAGCCATAGACTCTATTCACCA ACTTGGATTCATCCACAGAGACATCAAACCAGACAACCTTCTTTTGGACAGCAAGGGCCATGTGAAACTTTCTGACTTTGGTCTTTGCAC AGGACTGAAAAAAGCACATAGGACAGAATTTTATAGGAATCTGAACCACAGCCTCCCCAGTGATTTCACTTTCCAGAACATGAATTCCAA AAGGAAAGCAGAAACCTGGAAAAGAAATAGACGTCAGCTAGCCTTCTCCACAGTAGGCACTCCTGACTACATTGCTCCTGAGGTGTTCAT GCAGACCGGGTACAACAAGCTCTGTGATTGGTGGTCGCTTGGGGTGATCATGTATGAGATGCTCATCGGCTATGTGGTTGATGTTGCAGA ATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAA CCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACC GGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGG TGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTA CAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCT GCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTT GTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGT >In-frame_STK38_ENST00000229812_chr6_36467650_-_GMDS_ENST00000380815_chr6_1742820_-_1949nt CTCGGCCCCGGGCTGCCGCGCCAGCCCGTCTCCGCGGCGGGGGACCGGGCTGCCTTGGCCCCTCAGCGCTCGCGTCTTTTCCGGCAGTTG GAACGCTTCCTGTTGTCCTCACCCGTAACCGCCTGTTGCCCCCTGTCTCAGAGTCCCTCACGCGTCCCCTCCCGTCTTTGGCTCGTTGGC TGCCGCCGCCGGGGCTTCGCCAGCCTTCAAGTCGAGACTACTGGCCGAAGGGGCGTCTGCGGCTCTCCGCCGTCCCCAGCCCTGCCTCTC CCTGGGCTCTGCAGCCATGGCAATGACAGGCTCAACACCTTGCTCATCCATGAGTAACCACACAAAGGAAAGGGTGACAATGACCAAAGT GACACTGGAGAATTTTTATAGCAACCTTATCGCTCAACATGAAGAACGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGA AGGCCTAAAAGATGAGGAGAAACGACTCCGGAGATCAGCACATGCTCGGAAGGAAACAGAGTTTCTTCGTTTGAAGAGAACAAGACTTGG ATTGGAAGATTTTGAGTCCTTAAAAGTAATAGGCAGAGGAGCATTTGGTGAGGTACGGCTTGTTCAGAAGAAAGATACGGGACATGTGTA TGCAATGAAAATACTCCGTAAAGCAGATATGCTTGAAAAAGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATTCTAGTGGAGGCAGA CAGTTTGTGGGTTGTGAAAATGTTCTATAGTTTTCAGGATAAGCTAAACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGAT GACCTTGTTGATGAAAAAAGACACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAAACAGTATTAGCCATAGACTCTATTCACCA ACTTGGATTCATCCACAGAGACATCAAACCAGACAACCTTCTTTTGGACAGCAAGGGCCATGTGAAACTTTCTGACTTTGGTCTTTGCAC AGGACTGAAAAAAGCACATAGGACAGAATTTTATAGGAATCTGAACCACAGCCTCCCCAGTGATTTCACTTTCCAGAACATGAATTCCAA AAGGAAAGCAGAAACCTGGAAAAGAAATAGACGTCAGCTAGCCTTCTCCACAGTAGGCACTCCTGACTACATTGCTCCTGAGGTGTTCAT GCAGACCGGGTACAACAAGCTCTGTGATTGGTGGTCGCTTGGGGTGATCATGTATGAGATGCTCATCGGCTATGTGGTTGATGTTGCAGA ATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAA CCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACC GGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGG TGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTA CAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCT GCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTT GTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGT |
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FusionGenePPI for STK38_GMDS |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
STK38 | ISG15, HERC5, TRIM25, MYSM1, CTDP1, AGO3, YWHAB, YWHAZ, VHL, ARRB1, ARRB2, TCF3, MOB1B, MAP3K1, MAP3K2, GRK5, MOB2, MOB1A, CALM1, S100B, STK38, MTOR, RICTOR, MAPKAP1, NOTCH1, EIF4A3, MAGOH, SMURF1, HSP90AA1, NPM1, FBXO6, ZBTB1, MPP1, EWSR1, HIST2H2AC, HIST2H2BE, HIST1H3E, ID2, GAN, CDK8, CDK19, SKI, RC3H1, CCNB1, CRBN, SOCS2, CDH1, MARVELD2, CYLD, HEY1 | GMDS | GMDS, TNKS, BLVRB, BAG3, ATIC, CAPN2, CTH, NSFL1C, PTMA, RAP1GDS1, TATDN1, WDYHV1, RNF166, MAT2B, RAB2A, TTC5, NDUFA9, PSMG4, CCDC22, SKA1, NF2, FBXW7, TNKS2, HIF1AN, NPHP3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | STK38 | chr6:36467650 | chr6:1742820 | ENST00000229812 | - | 10 | 14 | 62_87 | 317 | 466 | S100B |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK38_GMDS |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK38_GMDS |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |