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Fusion gene ID: 36514 |
FusionGeneSummary for STK36_STK36 |
Fusion gene summary |
Fusion gene information | Fusion gene name: STK36_STK36 | Fusion gene ID: 36514 | Hgene | Tgene | Gene symbol | STK36 | STK36 | Gene ID | 27148 | 27148 |
Gene name | serine/threonine kinase 36 | serine/threonine kinase 36 | |
Synonyms | FU | FU | |
Cytomap | 2q35 | 2q35 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188 | serine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NRP7 | Q9NRP7 | |
Ensembl transtripts involved in fusion gene | ENST00000295709, ENST00000392106, ENST00000392105, ENST00000440309, | ENST00000295709, ENST00000392106, ENST00000392105, ENST00000440309, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: STK36 [Title/Abstract] AND STK36 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STK36 | GO:0051090 | regulation of DNA binding transcription factor activity | 10806483 |
Tgene | STK36 | GO:0051090 | regulation of DNA binding transcription factor activity | 10806483 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG991610 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000295709 | ENST00000295709 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000295709 | ENST00000392106 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000295709 | ENST00000392105 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000295709 | ENST00000440309 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392106 | ENST00000295709 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392106 | ENST00000392106 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392106 | ENST00000392105 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392106 | ENST00000440309 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392105 | ENST00000295709 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392105 | ENST00000392106 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392105 | ENST00000392105 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000392105 | ENST00000440309 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000440309 | ENST00000295709 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000440309 | ENST00000392106 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000440309 | ENST00000392105 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
Frame-shift | ENST00000440309 | ENST00000440309 | STK36 | chr2 | 219564070 | + | STK36 | chr2 | 219540786 | + |
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FusionProtFeatures for STK36_STK36 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
STK36 | STK36 |
Serine/threonine protein kinase which plays an importantrole in the sonic hedgehog (Shh) pathway by regulating theactivity of GLI transcription factors (PubMed:10806483). Controlsthe activity of the transcriptional regulators GLI1, GLI2 and GLI3by opposing the effect of SUFU and promoting their nuclearlocalization (PubMed:10806483). GLI2 requires an additionalfunction of STK36 to become transcriptionally active, but theenzyme does not need to possess an active kinase catalytic sitefor this to occur (PubMed:10806483). Required for postnataldevelopment, possibly by regulating the homeostasis of cerebralspinal fluid or ciliary function (By similarity). Essential forconstruction of the central pair apparatus of motile cilia.{ECO:0000250|UniProtKB:Q69ZM6, ECO:0000269|PubMed:10806483}. | Serine/threonine protein kinase which plays an importantrole in the sonic hedgehog (Shh) pathway by regulating theactivity of GLI transcription factors (PubMed:10806483). Controlsthe activity of the transcriptional regulators GLI1, GLI2 and GLI3by opposing the effect of SUFU and promoting their nuclearlocalization (PubMed:10806483). GLI2 requires an additionalfunction of STK36 to become transcriptionally active, but theenzyme does not need to possess an active kinase catalytic sitefor this to occur (PubMed:10806483). Required for postnataldevelopment, possibly by regulating the homeostasis of cerebralspinal fluid or ciliary function (By similarity). Essential forconstruction of the central pair apparatus of motile cilia.{ECO:0000250|UniProtKB:Q69ZM6, ECO:0000269|PubMed:10806483}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STK36_STK36 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STK36_STK36 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK36_STK36 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK36_STK36 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |