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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36514

FusionGeneSummary for STK36_STK36

check button Fusion gene summary
Fusion gene informationFusion gene name: STK36_STK36
Fusion gene ID: 36514
HgeneTgene
Gene symbol

STK36

STK36

Gene ID

27148

27148

Gene nameserine/threonine kinase 36serine/threonine kinase 36
SynonymsFUFU
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188serine/threonine-protein kinase 36fused homologtesticular tissue protein Li 188
Modification date2018051920180519
UniProtAcc

Q9NRP7

Q9NRP7

Ensembl transtripts involved in fusion geneENST00000295709, ENST00000392106, 
ENST00000392105, ENST00000440309, 
ENST00000295709, ENST00000392106, 
ENST00000392105, ENST00000440309, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STK36 [Title/Abstract] AND STK36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK36

GO:0051090

regulation of DNA binding transcription factor activity

10806483

TgeneSTK36

GO:0051090

regulation of DNA binding transcription factor activity

10806483


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG991610STK36chr2

219564070

+STK36chr2

219540786

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295709ENST00000295709STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000295709ENST00000392106STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000295709ENST00000392105STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000295709ENST00000440309STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392106ENST00000295709STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392106ENST00000392106STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392106ENST00000392105STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392106ENST00000440309STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392105ENST00000295709STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392105ENST00000392106STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392105ENST00000392105STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000392105ENST00000440309STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000440309ENST00000295709STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000440309ENST00000392106STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000440309ENST00000392105STK36chr2

219564070

+STK36chr2

219540786

+
Frame-shiftENST00000440309ENST00000440309STK36chr2

219564070

+STK36chr2

219540786

+

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FusionProtFeatures for STK36_STK36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK36

Q9NRP7

STK36

Q9NRP7

Serine/threonine protein kinase which plays an importantrole in the sonic hedgehog (Shh) pathway by regulating theactivity of GLI transcription factors (PubMed:10806483). Controlsthe activity of the transcriptional regulators GLI1, GLI2 and GLI3by opposing the effect of SUFU and promoting their nuclearlocalization (PubMed:10806483). GLI2 requires an additionalfunction of STK36 to become transcriptionally active, but theenzyme does not need to possess an active kinase catalytic sitefor this to occur (PubMed:10806483). Required for postnataldevelopment, possibly by regulating the homeostasis of cerebralspinal fluid or ciliary function (By similarity). Essential forconstruction of the central pair apparatus of motile cilia.{ECO:0000250|UniProtKB:Q69ZM6, ECO:0000269|PubMed:10806483}. Serine/threonine protein kinase which plays an importantrole in the sonic hedgehog (Shh) pathway by regulating theactivity of GLI transcription factors (PubMed:10806483). Controlsthe activity of the transcriptional regulators GLI1, GLI2 and GLI3by opposing the effect of SUFU and promoting their nuclearlocalization (PubMed:10806483). GLI2 requires an additionalfunction of STK36 to become transcriptionally active, but theenzyme does not need to possess an active kinase catalytic sitefor this to occur (PubMed:10806483). Required for postnataldevelopment, possibly by regulating the homeostasis of cerebralspinal fluid or ciliary function (By similarity). Essential forconstruction of the central pair apparatus of motile cilia.{ECO:0000250|UniProtKB:Q69ZM6, ECO:0000269|PubMed:10806483}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK36_STK36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK36_STK36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK36_STK36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK36_STK36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource