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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36510

FusionGeneSummary for STK32C_PWWP2B

check button Fusion gene summary
Fusion gene informationFusion gene name: STK32C_PWWP2B
Fusion gene ID: 36510
HgeneTgene
Gene symbol

STK32C

PWWP2B

Gene ID

282974

170394

Gene nameserine/threonine kinase 32CPWWP domain containing 2B
SynonymsPKE|YANK3PWWP2|bA432J24.1|pp8607
Cytomap

10q26.3

10q26.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 32CPKE protein kinasetesticular tissue protein Li 187yet another novel kinase 3PWWP domain-containing protein 2BPWWP domain containing 2
Modification date2018052320180519
UniProtAcc

Q86UX6

Q6NUJ5

Ensembl transtripts involved in fusion geneENST00000368622, ENST00000368625, 
ENST00000305233, ENST00000368609, 
Fusion gene scores* DoF score1 X 2 X 1=22 X 2 X 2=8
# samples 23
** MAII scorelog2(2/2*10)=3.32192809488736log2(3/8*10)=1.90689059560852
Context

PubMed: STK32C [Title/Abstract] AND PWWP2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A51B-01ASTK32Cchr10

134022538

-PWWP2Bchr10

134230565

+
TCGARVSKCMTCGA-Z2-AA3V-06ASTK32Cchr10

134059404

-PWWP2Bchr10

134230565

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000368622ENST00000305233STK32Cchr10

134022538

-PWWP2Bchr10

134230565

+
5CDS-3UTRENST00000368622ENST00000368609STK32Cchr10

134022538

-PWWP2Bchr10

134230565

+
5CDS-3UTRENST00000368625ENST00000305233STK32Cchr10

134022538

-PWWP2Bchr10

134230565

+
5CDS-3UTRENST00000368625ENST00000368609STK32Cchr10

134022538

-PWWP2Bchr10

134230565

+
5UTR-3UTRENST00000368622ENST00000305233STK32Cchr10

134059404

-PWWP2Bchr10

134230565

+
5UTR-3UTRENST00000368622ENST00000368609STK32Cchr10

134059404

-PWWP2Bchr10

134230565

+
5CDS-3UTRENST00000368625ENST00000305233STK32Cchr10

134059404

-PWWP2Bchr10

134230565

+
5CDS-3UTRENST00000368625ENST00000368609STK32Cchr10

134059404

-PWWP2Bchr10

134230565

+

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FusionProtFeatures for STK32C_PWWP2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK32C

Q86UX6

PWWP2B

Q6NUJ5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK32C_PWWP2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK32C_PWWP2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK32CGRB2, C18orf8, HSP90AA1, HSP90AA5P, HSP90AA4P, FDFT1, CDC37, MCM5PWWP2BPSMA3, BRD2, ZNF131, HDAC1, P4HA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK32C_PWWP2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK32C_PWWP2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePWWP2BC0032460Polycystic Ovary Syndrome1CTD_human