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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36501

FusionGeneSummary for STK24_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: STK24_RUNX1
Fusion gene ID: 36501
HgeneTgene
Gene symbol

STK24

RUNX1

Gene ID

8428

861

Gene nameserine/threonine kinase 24runt related transcription factor 1
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

13q32.2

21q22.12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018052320180527
UniProtAcc

Q9Y6E0

Q01196

Ensembl transtripts involved in fusion geneENST00000397517, ENST00000539966, 
ENST00000481288, ENST00000376547, 
ENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
Fusion gene scores* DoF score11 X 5 X 9=49517 X 29 X 7=3451
# samples 1833
** MAII scorelog2(18/495*10)=-1.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STK24 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK24

GO:0006468

protein phosphorylation

19604147

HgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A135-01ASTK24chr13

99171497

-RUNX1chr21

36953227

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000397517ENST00000344691STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000325074STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000437180STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000300305STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000399240STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000486278STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000494829STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000397517ENST00000358356STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000344691STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000325074STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000437180STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000300305STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000399240STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000486278STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000494829STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000539966ENST00000358356STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000344691STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000325074STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000437180STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000300305STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000399240STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000486278STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000494829STK24chr13

99171497

-RUNX1chr21

36953227

-
5UTR-intronENST00000481288ENST00000358356STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000344691STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000325074STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000437180STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000300305STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000399240STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000486278STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000494829STK24chr13

99171497

-RUNX1chr21

36953227

-
5CDS-intronENST00000376547ENST00000358356STK24chr13

99171497

-RUNX1chr21

36953227

-

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FusionProtFeatures for STK24_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK24

Q9Y6E0

RUNX1

Q01196

Serine/threonine-protein kinase that acts on both serineand threonine residues and promotes apoptosis in response tostress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) duringoxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nucleartranslocation of AIFM1 and ENDOG and the DNase activity associatedwith ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates itskinase activity. In association with STK26 negatively regulatesGolgi reorientation in polarized cell migration upon RHOactivation (PubMed:27807006). Regulates also cellular migrationwith alteration of PTPN12 activity and PXN phosphorylation:phosphorylates PTPN12 and inhibits its activity and may regulatePXN phosphorylation through PTPN12. May act as a key regulator ofaxon regeneration in the optic nerve and radial nerve.{ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825,ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762,ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK24_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK24_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK24PDCD10, STRN, MCC, STRN3, PPP2R1A, STRN4, MOB4, STK25, STRIP1, PPP2CB, SLMAP, APOD, DDX5, G3BP2, HNRNPH3, PDCD6IP, ZBTB24, JPH3, SYNCRIP, HNRNPA3, FABP5, DSP, CTTNBP2NL, SIKE1, PPP2CA, PPP2R1B, STRIP2, CCT2, CCT8, CTTNBP2, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, TRAF3IP3, NEDD4, VAV2, ELAVL1, LRRK2, CEP135, RPL12, ALDH7A1, ASNS, EIF5, ISOC1, MAT2B, MSN, PDIA4, PPP1CA, SCPEP1, PRCP, TBCB, VCL, TUBB, XPO1, DYNLL1, PROSER2, STK26, STK24, C4orf19, MAGIX, ATP6V1C2, COG5, MAD1L1, TRMT6, TLK2, ERBB2, STK11, CEP19, LRPPRC, WRAP53, CDC5L, CDH1, TRIM25RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK24_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK24_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human