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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36488

FusionGeneSummary for STK17A_TMEM123

check button Fusion gene summary
Fusion gene informationFusion gene name: STK17A_TMEM123
Fusion gene ID: 36488
HgeneTgene
Gene symbol

STK17A

TMEM123

Gene ID

9263

114908

Gene nameserine/threonine kinase 17atransmembrane protein 123
SynonymsDRAK1KCT3|PORIMIN|PORMIN
Cytomap

7p13

11q22.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 17ADAP kinase-related apoptosis-inducing protein kinase 1death-associated protein kinase-related 1serine/threonine kinase 17a (apoptosis-inducing)poriminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptor
Modification date2018052320180523
UniProtAcc

Q9UEE5

Q8N131

Ensembl transtripts involved in fusion geneENST00000462448, ENST00000319357, 
ENST00000361236, ENST00000398136, 
ENST00000532161, ENST00000525577, 
Fusion gene scores* DoF score2 X 5 X 1=105 X 4 X 2=40
# samples 55
** MAII scorelog2(5/10*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STK17A [Title/Abstract] AND TMEM123 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK17A

GO:0006468

protein phosphorylation

9786912

HgeneSTK17A

GO:0035556

intracellular signal transduction

9786912

TgeneTMEM123

GO:0070267

oncosis

9600958|11481458


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN282882STK17Achr7

43665335

+TMEM123chr11

102268118

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000462448ENST00000361236STK17Achr7

43665335

+TMEM123chr11

102268118

-
intron-3UTRENST00000462448ENST00000398136STK17Achr7

43665335

+TMEM123chr11

102268118

-
intron-intronENST00000462448ENST00000532161STK17Achr7

43665335

+TMEM123chr11

102268118

-
intron-intronENST00000462448ENST00000525577STK17Achr7

43665335

+TMEM123chr11

102268118

-
3UTR-3UTRENST00000319357ENST00000361236STK17Achr7

43665335

+TMEM123chr11

102268118

-
3UTR-3UTRENST00000319357ENST00000398136STK17Achr7

43665335

+TMEM123chr11

102268118

-
3UTR-intronENST00000319357ENST00000532161STK17Achr7

43665335

+TMEM123chr11

102268118

-
3UTR-intronENST00000319357ENST00000525577STK17Achr7

43665335

+TMEM123chr11

102268118

-

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FusionProtFeatures for STK17A_TMEM123


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK17A

Q9UEE5

TMEM123

Q8N131

Acts as a positive regulator of apoptosis. Also acts asa regulator of cellular reactive oxygen species.{ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. Implicated in oncotic cell death, characterized by cellswelling, organelle swelling, vacuolization and increased membranepermeability. {ECO:0000269|PubMed:11481458}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK17A_TMEM123


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK17A_TMEM123


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK17A_TMEM123


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK17A_TMEM123


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource