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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36487

FusionGeneSummary for STK17A_STK17A

check button Fusion gene summary
Fusion gene informationFusion gene name: STK17A_STK17A
Fusion gene ID: 36487
HgeneTgene
Gene symbol

STK17A

STK17A

Gene ID

9263

9263

Gene nameserine/threonine kinase 17aserine/threonine kinase 17a
SynonymsDRAK1DRAK1
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 17ADAP kinase-related apoptosis-inducing protein kinase 1death-associated protein kinase-related 1serine/threonine kinase 17a (apoptosis-inducing)serine/threonine-protein kinase 17ADAP kinase-related apoptosis-inducing protein kinase 1death-associated protein kinase-related 1serine/threonine kinase 17a (apoptosis-inducing)
Modification date2018052320180523
UniProtAcc

Q9UEE5

Q9UEE5

Ensembl transtripts involved in fusion geneENST00000462448, ENST00000319357, 
ENST00000462448, ENST00000319357, 
Fusion gene scores* DoF score2 X 5 X 1=103 X 5 X 2=30
# samples 56
** MAII scorelog2(5/10*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STK17A [Title/Abstract] AND STK17A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK17A

GO:0006468

protein phosphorylation

9786912

HgeneSTK17A

GO:0035556

intracellular signal transduction

9786912

TgeneSTK17A

GO:0006468

protein phosphorylation

9786912

TgeneSTK17A

GO:0035556

intracellular signal transduction

9786912


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW804357STK17Achr7

43664566

-STK17Achr7

43664608

+
ChiTaRS3.1BE151748STK17Achr7

43661392

-STK17Achr7

43661328

+
ChiTaRS3.1BM968928STK17Achr7

43664480

-STK17Achr7

43663465

+
ChiTaRS3.1BM969318STK17Achr7

43648591

+STK17Achr7

43648627

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000462448ENST00000462448STK17Achr7

43664566

-STK17Achr7

43664608

+
intron-3UTRENST00000462448ENST00000319357STK17Achr7

43664566

-STK17Achr7

43664608

+
3UTR-intronENST00000319357ENST00000462448STK17Achr7

43664566

-STK17Achr7

43664608

+
3UTR-3UTRENST00000319357ENST00000319357STK17Achr7

43664566

-STK17Achr7

43664608

+
intron-intronENST00000462448ENST00000462448STK17Achr7

43661392

-STK17Achr7

43661328

+
intron-intronENST00000462448ENST00000319357STK17Achr7

43661392

-STK17Achr7

43661328

+
intron-intronENST00000319357ENST00000462448STK17Achr7

43661392

-STK17Achr7

43661328

+
intron-intronENST00000319357ENST00000319357STK17Achr7

43661392

-STK17Achr7

43661328

+
intron-intronENST00000462448ENST00000462448STK17Achr7

43664480

-STK17Achr7

43663465

+
intron-intronENST00000462448ENST00000319357STK17Achr7

43664480

-STK17Achr7

43663465

+
3UTR-intronENST00000319357ENST00000462448STK17Achr7

43664480

-STK17Achr7

43663465

+
3UTR-intronENST00000319357ENST00000319357STK17Achr7

43664480

-STK17Achr7

43663465

+
intron-intronENST00000462448ENST00000462448STK17Achr7

43648591

+STK17Achr7

43648627

-
intron-intronENST00000462448ENST00000319357STK17Achr7

43648591

+STK17Achr7

43648627

-
intron-intronENST00000319357ENST00000462448STK17Achr7

43648591

+STK17Achr7

43648627

-
intron-intronENST00000319357ENST00000319357STK17Achr7

43648591

+STK17Achr7

43648627

-

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FusionProtFeatures for STK17A_STK17A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK17A

Q9UEE5

STK17A

Q9UEE5

Acts as a positive regulator of apoptosis. Also acts asa regulator of cellular reactive oxygen species.{ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. Acts as a positive regulator of apoptosis. Also acts asa regulator of cellular reactive oxygen species.{ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK17A_STK17A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK17A_STK17A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK17A_STK17A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK17A_STK17A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource