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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36480

FusionGeneSummary for STK11_GPX4

check button Fusion gene summary
Fusion gene informationFusion gene name: STK11_GPX4
Fusion gene ID: 36480
HgeneTgene
Gene symbol

STK11

GPX4

Gene ID

6794

2879

Gene nameserine/threonine kinase 11glutathione peroxidase 4
SynonymsLKB1|PJS|hLKB1GPx-4|GSHPx-4|MCSP|PHGPx|SMDS|snGPx|snPHGPx
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1phospholipid hydroperoxide glutathione peroxidasephospholipid hydroperoxidasephospholipid hydroperoxide glutathione peroxidase, mitochondrialsperm nucleus glutathione peroxidase
Modification date2018052220180522
UniProtAcc

Q15831

P36969

Ensembl transtripts involved in fusion geneENST00000585748, ENST00000326873, 
ENST00000354171, ENST00000589115, 
Fusion gene scores* DoF score9 X 2 X 5=904 X 3 X 3=36
# samples 94
** MAII scorelog2(9/90*10)=0log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STK11 [Title/Abstract] AND GPX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK11

GO:0006468

protein phosphorylation

12805220|25329316

HgeneSTK11

GO:0007050

cell cycle arrest

12805220|17216128

HgeneSTK11

GO:0046777

protein autophosphorylation

11430832

HgeneSTK11

GO:0071493

cellular response to UV-B

25329316

HgeneSTK11

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11430832


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A26X-01ASTK11chr19

1222005

+GPX4chr19

1105185

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000585748ENST00000354171STK11chr19

1222005

+GPX4chr19

1105185

+
intron-3CDSENST00000585748ENST00000589115STK11chr19

1222005

+GPX4chr19

1105185

+
Frame-shitENST00000326873ENST00000354171STK11chr19

1222005

+GPX4chr19

1105185

+
Frame-shitENST00000326873ENST00000589115STK11chr19

1222005

+GPX4chr19

1105185

+

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FusionProtFeatures for STK11_GPX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK11

Q15831

GPX4

P36969

Tumor suppressor serine/threonine-protein kinase thatcontrols the activity of AMP-activated protein kinase (AMPK)family members, thereby playing a role in various processes suchas cell metabolism, cell polarity, apoptosis and DNA damageresponse. Acts by phosphorylating the T-loop of AMPK familyproteins, thus promoting their activity: phosphorylates PRKAA1,PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2,SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53.Acts as a key upstream regulator of AMPK by mediatingphosphorylation and activation of AMPK catalytic subunits PRKAA1and PRKAA2 and thereby regulates processes including: inhibitionof signaling pathways that promote cell growth and proliferationwhen energy levels are low, glucose homeostasis in liver,activation of autophagy when cells undergo nutrient deprivation,and B-cell differentiation in the germinal center in response toDNA damage. Also acts as a regulator of cellular polarity byremodeling the actin cytoskeleton. Required for cortical neuronpolarization by mediating phosphorylation and activation of BRSK1and BRSK2, leading to axon initiation and specification. Involvedin DNA damage response: interacts with p53/TP53 and recruited tothe CDKN1A/WAF1 promoter to participate in transcriptionactivation. Able to phosphorylate p53/TP53; the relevance of suchresult in vivo is however unclear and phosphorylation may beindirect and mediated by downstream STK11/LKB1 kinase NUAK1. Alsoacts as a mediator of p53/TP53-dependent apoptosis via interactionwith p53/TP53: translocates to the mitochondrion during apoptosisand regulates p53/TP53-dependent apoptosis pathways. In veinendothelial cells, inhibits PI3K/Akt signaling activity and thusinduces apoptosis in response to the oxidant peroxynitrite (invitro). Regulates UV radiation-induced DNA damage responsemediated by CDKN1A. In association with NUAK1, phosphorylatesCDKN1A in response to UV radiation and contributes to itsdegradation which is necessary for optimal DNA repair(PubMed:25329316). {ECO:0000269|PubMed:11430832,ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248,ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379,ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703,ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:18321849,ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. Isoform 2: Has a role in spermiogenesis. {ECO:0000250}. Essential antioxidant peroxidase that directly reducesphospholipid hydroperoxide even if they are incorporated inmembranes and lipoproteins (By similarity). Can also reduce fattyacid hydroperoxide, cholesterol hydroperoxide and thyminehydroperoxide (By similarity). Plays a key role in protectingcells from oxidative damage by preventing membrane lipidperoxidation (By similarity). Required to prevent cells fromferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species(PubMed:24439385). The presence of selenocysteine (Sec) versus Cysat the active site is essential for life: it provides resistanceto overoxidation and prevents cells against ferroptosis (Bysimilarity). The presence of Sec at the active site is alsoessential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epilepticseizures (By similarity). May be required to protect cells fromthe toxicity of ingested lipid hydroperoxides (By similarity).Required for normal sperm development and male fertility (Bysimilarity). Essential for maturation and survival ofphotoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (Bysimilarity). {ECO:0000250|UniProtKB:O70325,ECO:0000250|UniProtKB:P36968, ECO:0000269|PubMed:24439385}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK11_GPX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK11_GPX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK11CAB39, STRADA, SMARCA4, STK11IP, TP53, WDR48, FKBP5, STRADB, CAB39L, CDC37, HSP90AA1, MARK4, HSPA1A, RPAP3, USP11, LIMS1, KIF23, SMARCC1, GSK3B, MARK2, SIK1, STUB1, UBE2D2, TNIP2, APP, SNRK, AP2M1, EIF2B1, ETV4, TP63, SIRT1, PRKAA1, SPDEF, MAPRE1, CCDC136, COPS3, COPS4, H2AFX, WDR6, BCAS3, CYP17A1, KLK7, LYPD3, NAT2, RHOBTB2, S100A14, SERPINB5, ST14, THRSP, TRIM25, PRSS50, ADIPOR1, ARG2, CALM2, CFL2, CRY2, CTSB, D2HGDH, EEF1A2, ERLEC1, FAIM2, GNPDA1, ND2, MOCS2, PDXP, PHF23, PLD3, SEPT9, STK24, THOP1, TSG101, TUBA1A, TUBB4A, VPS72, TBC1D23, RPS6KB1, PRKAA2, HERC2, KDM4A, HSP90AA4P, HSP90AB3P, PIP4K2A, HSP90AB4P, C5orf24, HSP90AA5P, HSP90AB1, FAM175B, DVL2, IVD, NEMF, CSNK2A1, MAP2K1GPX4OTUD5, MAPK13, PRDX6, AKR1B1, ALDOA, ALDOC, DUT, ENO1, ENO2, ENO3, FKBP1A, GLRX2, ERO1LB, ETFA, ETFB, EZR, FKBP2, HINT1, HSD17B10, IMPA2, NUTF2, PGAM4, SOD1, SOD2, TAGLN, TAGLN2, TKT, UCHL3, VDAC1, VDAC2, HSPE1, ME1, PIN1, PPIF, PRDX2, STIP1, CEP170, OTUB1, GSTO2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK11_GPX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGPX4P36969DB00143GlutathionePhospholipid hydroperoxide glutathione peroxidasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for STK11_GPX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTK11C0031269Peutz-Jeghers Syndrome7CTD_human;ORPHANET;UNIPROT
HgeneSTK11C1336708Testicular Germ Cell Tumor3CTD_human;UNIPROT
HgeneSTK11C0001418Adenocarcinoma1CTD_human
HgeneSTK11C0007137Squamous cell carcinoma1CTD_human
HgeneSTK11C0020538Hypertensive disease1CTD_human
HgeneSTK11C0024121Lung Neoplasms1CTD_human
HgeneSTK11C0030297Pancreatic Neoplasm1CTD_human;HPO
HgeneSTK11C0149721Left Ventricular Hypertrophy1CTD_human
HgeneSTK11C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneSTK11C1257915Intestinal Polyposis1CTD_human
TgeneGPX4C0021364Male infertility2CTD_human
TgeneGPX4C0006635Cadmium poisoning1CTD_human
TgeneGPX4C0009404Colorectal Neoplasms1CTD_human
TgeneGPX4C0010417Cryptorchidism1CTD_human
TgeneGPX4C0015695Fatty Liver1CTD_human
TgeneGPX4C0016059Fibrosis1CTD_human
TgeneGPX4C0018801Heart failure1CTD_human
TgeneGPX4C0271650Impaired glucose tolerance1CTD_human
TgeneGPX4C0752351Embryo Loss1CTD_human
TgeneGPX4C1458155Mammary Neoplasms1CTD_human