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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 3648

FusionGeneSummary for AVL9_ZNF544

check button Fusion gene summary
Fusion gene informationFusion gene name: AVL9_ZNF544
Fusion gene ID: 3648
HgeneTgene
Gene symbol

AVL9

ZNF544

Gene ID

23080

27300

Gene nameAVL9 cell migration associatedzinc finger protein 544
SynonymsKIAA0241-
Cytomap

7p14.3

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionlate secretory pathway protein AVL9 homologAVL9 homolog (S. cerevisiase)zinc finger protein 544
Modification date2018052320180519
UniProtAcc

Q8NBF6

Q6NX49

Ensembl transtripts involved in fusion geneENST00000404479, ENST00000318709, 
ENST00000459629, ENST00000409301, 
ENST00000599227, ENST00000269829, 
ENST00000594384, ENST00000596597, 
ENST00000596825, ENST00000333581, 
ENST00000599953, ENST00000596652, 
ENST00000600044, ENST00000600220, 
ENST00000596929, ENST00000595981, 
ENST00000415203, 
Fusion gene scores* DoF score6 X 6 X 3=1085 X 4 X 4=80
# samples 76
** MAII scorelog2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVL9 [Title/Abstract] AND ZNF544 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAVL9

GO:0016477

cell migration

22595670


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-32-1970-01AAVL9chr7

32535414

+ZNF544chr19

58772217

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000404479ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000404479ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000404479ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000318709ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000318709ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000318709ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-3CDSENST00000459629ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-3CDSENST00000459629ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-3CDSENST00000459629ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000409301ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000409301ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000409301ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+

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FusionProtFeatures for AVL9_ZNF544


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AVL9

Q8NBF6

ZNF544

Q6NX49

Functions in cell migration.{ECO:0000269|PubMed:22595670}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57354_37481716Zinc fingerC2H2-type 1%3B atypical
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57380_40281716Zinc fingerC2H2-type 2
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57408_43081716Zinc fingerC2H2-type 3
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57436_45881716Zinc fingerC2H2-type 4
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57464_48681716Zinc fingerC2H2-type 5
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57492_51481716Zinc fingerC2H2-type 6
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57520_54281716Zinc fingerC2H2-type 7
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57548_57081716Zinc fingerC2H2-type 8
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57576_59881716Zinc fingerC2H2-type 9
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57604_62681716Zinc fingerC2H2-type 10
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57632_65481716Zinc fingerC2H2-type 11
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57660_68281716Zinc fingerC2H2-type 12
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+57688_71081716Zinc fingerC2H2-type 13
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46354_37481716Zinc fingerC2H2-type 1%3B atypical
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46380_40281716Zinc fingerC2H2-type 2
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46408_43081716Zinc fingerC2H2-type 3
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46436_45881716Zinc fingerC2H2-type 4
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46464_48681716Zinc fingerC2H2-type 5
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46492_51481716Zinc fingerC2H2-type 6
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46520_54281716Zinc fingerC2H2-type 7
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46548_57081716Zinc fingerC2H2-type 8
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46576_59881716Zinc fingerC2H2-type 9
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46604_62681716Zinc fingerC2H2-type 10
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46632_65481716Zinc fingerC2H2-type 11
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46660_68281716Zinc fingerC2H2-type 12
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+46688_71081716Zinc fingerC2H2-type 13

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116173_34031649DomaincDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+11617_16131649DomainuDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116342_59331649DomaindDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116214_23031649TransmembraneHelical
TgeneZNF544chr7:32535414chr19:58772217ENST00000269829+5714_8581716DomainKRAB
TgeneZNF544chr7:32535414chr19:58772217ENST00000596652+4614_8581716DomainKRAB


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FusionGeneSequence for AVL9_ZNF544


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_37aa

>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_37aa

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_37aa

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_37aa

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_37aa

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_37aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC

>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_112nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_2887nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACA
GGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGATCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCCTTGA
GGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTGTGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCTACTT
TAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCCCAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCTTTCA
TTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCAGTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGTAAAC
TTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAGTGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTTCATG
GTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAACCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAGCCAG
TGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTGTTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGTGGCC
CTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCATGGCCTCATCTTTTTCTGACTGTAACATCATTCAGACTACAG
AGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAAGCTCATACACCAGAGAACACACACTGGAGAAAAGCCCTTCG
AATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCATACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGTG
ACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAAT
GCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAATTCATACTGGAGAGAAACCGTATGAGTGCACTCACTGTGGAA
AGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACACTGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAATCTT
TCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTCTCCC
AGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGGAACT
CTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGATTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATCAGT
TAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAACGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTCATCA
GGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTGCAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATGCATC
AGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAAAGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCACAGAA
TTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTTCCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACACATA
CTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCAGAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTCGGTG
GGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATTGAACATCAGAGGACATATCCTGGAGAAAAGCCCTACGAATG
CATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACACGAGAGGACACACACTGGAGGCAAACCCTATGAATGTGACCA
TTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGAATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAATGTG
GAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCATGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCGGGTG
CAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTGGATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGTAACA
TGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGTGGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTG
GGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCATGCCATCACACCGCTGCCTTGTGAGAGATTGAGACACTCTA
AATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACTAGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGGGCTT
CATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTATTACCAAGCTCACTCTAGCCAACTAAATAAAAATCTCTGGC

>In-frame_AVL9_ENST00000404479_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_208nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACA

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_3108nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGA
TCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACAGGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGA
TCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCCTTGAGGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTG
TGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCTACTTTAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCC
CAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCTTTCATTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCA
GTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGTAAACTTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAG
TGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTTCATGGTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAA
CCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAGCCAGTGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTG
TTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGTGGCCCTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCAT
GGCCTCATCTTTTTCTGACTGTAACATCATTCAGACTACAGAGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAA
GCTCATACACCAGAGAACACACACTGGAGAAAAGCCCTTCGAATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCAT
ACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGTGACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCA
GCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAAT
TCATACTGGAGAGAAACCGTATGAGTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACAC
TGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAATCTTTCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGA
GAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTCTCCCAGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACC
GTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGGAACTCTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGA
TTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATCAGTTAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAA
CGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTCATCAGGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTG
CAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATGCATCAGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAA
AGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCACAGAATTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTT
CCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACACATACTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCA
GAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTCGGTGGGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATT
GAACATCAGAGGACATATCCTGGAGAAAAGCCCTACGAATGCATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACAC
GAGAGGACACACACTGGAGGCAAACCCTATGAATGTGACCATTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGA
ATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAATGTGGAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCA
TGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCGGGTGCAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTG
GATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGTAACATGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGT
GGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCA
TGCCATCACACCGCTGCCTTGTGAGAGATTGAGACACTCTAAATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACT
AGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGGGCTTCATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTA

>In-frame_AVL9_ENST00000318709_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_429nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGA

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000599227_chr19_58772217_+_3071nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTG
TACAGGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGATCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCC
TTGAGGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTGTGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCT
ACTTTAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCCCAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCT
TTCATTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCAGTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGT
AAACTTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAGTGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTT
CATGGTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAACCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAG
CCAGTGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTGTTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGT
GGCCCTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCATGGCCTCATCTTTTTCTGACTGTAACATCATTCAGACT
ACAGAGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAAGCTCATACACCAGAGAACACACACTGGAGAAAAGCCC
TTCGAATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCATACATCAGAGGACACACACTGGAGAGAAGCCCTATGAG
TGTGACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATT
GAATGCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAATTCATACTGGAGAGAAACCGTATGAGTGCACTCACTGT
GGAAAGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACACTGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAA
TCTTTCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTC
TCCCAGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGG
AACTCTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGATTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTAT
CAGTTAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAACGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTC
ATCAGGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTGCAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATG
CATCAGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAAAGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCAC
AGAATTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTTCCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACA
CATACTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCAGAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTC
GGTGGGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATTGAACATCAGAGGACATATCCTGGAGAAAAGCCCTACG
AATGCATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACACGAGAGGACACACACTGGAGGCAAACCCTATGAATGTG
ACCATTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGAATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAA
TGTGGAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCATGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCG
GGTGCAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTGGATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGT
AACATGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGTGGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGA
GGTGGGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCATGCCATCACACCGCTGCCTTGTGAGAGATTGAGACAC
TCTAAATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACTAGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGG
GCTTCATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTATTACCAAGCTCACTCTAGCCAACTAAATAAAAATCTC

>In-frame_AVL9_ENST00000409301_chr7_32535414_+_ZNF544_ENST00000594384_chr19_58772217_+_392nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTG


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FusionGenePPI for AVL9_ZNF544


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AVL9HECW2, NTRK1, KLC1, NFKBIA, PER3, POT1, PARD6B, ELMSAN1, FAM19A4, TESZNF544TRAF2, GLRX3, TSGA10, NDEL1, SHMT2, MOV10, NXF1, RABIF, ZAK, GNPAT, CENPB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AVL9_ZNF544


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AVL9_ZNF544


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAVL9C3495559Juvenile arthritis1CTD_human