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Fusion gene ID: 36477 |
FusionGeneSummary for STK11_AZU1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK11_AZU1 | Fusion gene ID: 36477 | Hgene | Tgene | Gene symbol | STK11 | AZU1 | Gene ID | 6794 | 566 |
| Gene name | serine/threonine kinase 11 | azurocidin 1 | |
| Synonyms | LKB1|PJS|hLKB1 | AZAMP|AZU|CAP37|HBP|HUMAZUR|NAZC|hHBP | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1 | azurocidincationic antimicrobial protein 37cationic antimicrobial protein CAP37heparin-binding proteinneutrophil azurocidin | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q15831 | P20160 | |
| Ensembl transtripts involved in fusion gene | ENST00000585748, ENST00000326873, | ENST00000233997, | |
| Fusion gene scores | * DoF score | 9 X 2 X 5=90 | 2 X 1 X 2=4 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/90*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: STK11 [Title/Abstract] AND AZU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK11 | GO:0006468 | protein phosphorylation | 12805220|25329316 |
| Hgene | STK11 | GO:0007050 | cell cycle arrest | 12805220|17216128 |
| Hgene | STK11 | GO:0046777 | protein autophosphorylation | 11430832 |
| Hgene | STK11 | GO:0071493 | cellular response to UV-B | 25329316 |
| Hgene | STK11 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11430832 |
| Tgene | AZU1 | GO:0006508 | proteolysis | 21550830 |
| Tgene | AZU1 | GO:0008347 | glial cell migration | 12465046 |
| Tgene | AZU1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24008408 |
| Tgene | AZU1 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 12465046 |
| Tgene | AZU1 | GO:0045785 | positive regulation of cell adhesion | 12826073|15879141 |
| Tgene | AZU1 | GO:0045860 | positive regulation of protein kinase activity | 24008408 |
| Tgene | AZU1 | GO:0050725 | positive regulation of interleukin-1 beta biosynthetic process | 12465046 |
| Tgene | AZU1 | GO:0050754 | positive regulation of fractalkine biosynthetic process | 12465046 |
| Tgene | AZU1 | GO:0050766 | positive regulation of phagocytosis | 12465046 |
| Tgene | AZU1 | GO:0070944 | neutrophil mediated killing of bacterium | 2312733 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-RL-AAAS-01A | STK11 | chr19 | 1207202 | + | AZU1 | chr19 | 828230 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000585748 | ENST00000233997 | STK11 | chr19 | 1207202 | + | AZU1 | chr19 | 828230 | + |
| Frame-shift | ENST00000326873 | ENST00000233997 | STK11 | chr19 | 1207202 | + | AZU1 | chr19 | 828230 | + |
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FusionProtFeatures for STK11_AZU1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK11 | AZU1 |
| Tumor suppressor serine/threonine-protein kinase thatcontrols the activity of AMP-activated protein kinase (AMPK)family members, thereby playing a role in various processes suchas cell metabolism, cell polarity, apoptosis and DNA damageresponse. Acts by phosphorylating the T-loop of AMPK familyproteins, thus promoting their activity: phosphorylates PRKAA1,PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2,SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53.Acts as a key upstream regulator of AMPK by mediatingphosphorylation and activation of AMPK catalytic subunits PRKAA1and PRKAA2 and thereby regulates processes including: inhibitionof signaling pathways that promote cell growth and proliferationwhen energy levels are low, glucose homeostasis in liver,activation of autophagy when cells undergo nutrient deprivation,and B-cell differentiation in the germinal center in response toDNA damage. Also acts as a regulator of cellular polarity byremodeling the actin cytoskeleton. Required for cortical neuronpolarization by mediating phosphorylation and activation of BRSK1and BRSK2, leading to axon initiation and specification. Involvedin DNA damage response: interacts with p53/TP53 and recruited tothe CDKN1A/WAF1 promoter to participate in transcriptionactivation. Able to phosphorylate p53/TP53; the relevance of suchresult in vivo is however unclear and phosphorylation may beindirect and mediated by downstream STK11/LKB1 kinase NUAK1. Alsoacts as a mediator of p53/TP53-dependent apoptosis via interactionwith p53/TP53: translocates to the mitochondrion during apoptosisand regulates p53/TP53-dependent apoptosis pathways. In veinendothelial cells, inhibits PI3K/Akt signaling activity and thusinduces apoptosis in response to the oxidant peroxynitrite (invitro). Regulates UV radiation-induced DNA damage responsemediated by CDKN1A. In association with NUAK1, phosphorylatesCDKN1A in response to UV radiation and contributes to itsdegradation which is necessary for optimal DNA repair(PubMed:25329316). {ECO:0000269|PubMed:11430832,ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248,ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379,ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703,ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:18321849,ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. Isoform 2: Has a role in spermiogenesis. {ECO:0000250}. | This is a neutrophil granule-derived antibacterial andmonocyte- and fibroblast-specific chemotactic glycoprotein. Bindsheparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strongaffinity of the very basic N-terminal half for the negativelycharged lipopolysaccharides that are unique to the Gram-negativebacterial outer envelope. It may play a role in mediatingrecruitment of monocytes in the second wave of inflammation. Hasantibacterial activity against the Gram-nagative bacteriumP.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.Acting alone, it does not have antimicrobial activity against theGram-negative bacteria A.actinomycetemcomitans ATCC 29532,A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4,H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872or E.coli ML-35. Has antibacterial activity against C.sputigenaATCC 33123 when acting synergistically with either elastase orcathepsin G. {ECO:0000269|PubMed:1399008,ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2312733}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STK11_AZU1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STK11_AZU1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STK11 | CAB39, STRADA, SMARCA4, STK11IP, TP53, WDR48, FKBP5, STRADB, CAB39L, CDC37, HSP90AA1, MARK4, HSPA1A, RPAP3, USP11, LIMS1, KIF23, SMARCC1, GSK3B, MARK2, SIK1, STUB1, UBE2D2, TNIP2, APP, SNRK, AP2M1, EIF2B1, ETV4, TP63, SIRT1, PRKAA1, SPDEF, MAPRE1, CCDC136, COPS3, COPS4, H2AFX, WDR6, BCAS3, CYP17A1, KLK7, LYPD3, NAT2, RHOBTB2, S100A14, SERPINB5, ST14, THRSP, TRIM25, PRSS50, ADIPOR1, ARG2, CALM2, CFL2, CRY2, CTSB, D2HGDH, EEF1A2, ERLEC1, FAIM2, GNPDA1, ND2, MOCS2, PDXP, PHF23, PLD3, SEPT9, STK24, THOP1, TSG101, TUBA1A, TUBB4A, VPS72, TBC1D23, RPS6KB1, PRKAA2, HERC2, KDM4A, HSP90AA4P, HSP90AB3P, PIP4K2A, HSP90AB4P, C5orf24, HSP90AA5P, HSP90AB1, FAM175B, DVL2, IVD, NEMF, CSNK2A1, MAP2K1 | AZU1 | CLEC4G, RAD21, ZYG11B, SH3GL2, SH3GL1, ERBB2IP, KBTBD6, BIN3, CBWD3, OSBPL6, STAT3, DIEXF, FBXO2, FIGNL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STK11_AZU1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STK11_AZU1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STK11 | C0031269 | Peutz-Jeghers Syndrome | 7 | CTD_human;ORPHANET;UNIPROT |
| Hgene | STK11 | C1336708 | Testicular Germ Cell Tumor | 3 | CTD_human;UNIPROT |
| Hgene | STK11 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | STK11 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | STK11 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | STK11 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | STK11 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human;HPO |
| Hgene | STK11 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| Hgene | STK11 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | STK11 | C1257915 | Intestinal Polyposis | 1 | CTD_human |
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