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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36477

FusionGeneSummary for STK11_AZU1

check button Fusion gene summary
Fusion gene informationFusion gene name: STK11_AZU1
Fusion gene ID: 36477
HgeneTgene
Gene symbol

STK11

AZU1

Gene ID

6794

566

Gene nameserine/threonine kinase 11azurocidin 1
SynonymsLKB1|PJS|hLKB1AZAMP|AZU|CAP37|HBP|HUMAZUR|NAZC|hHBP
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1azurocidincationic antimicrobial protein 37cationic antimicrobial protein CAP37heparin-binding proteinneutrophil azurocidin
Modification date2018052220180523
UniProtAcc

Q15831

P20160

Ensembl transtripts involved in fusion geneENST00000585748, ENST00000326873, 
ENST00000233997, 
Fusion gene scores* DoF score9 X 2 X 5=902 X 1 X 2=4
# samples 92
** MAII scorelog2(9/90*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: STK11 [Title/Abstract] AND AZU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK11

GO:0006468

protein phosphorylation

12805220|25329316

HgeneSTK11

GO:0007050

cell cycle arrest

12805220|17216128

HgeneSTK11

GO:0046777

protein autophosphorylation

11430832

HgeneSTK11

GO:0071493

cellular response to UV-B

25329316

HgeneSTK11

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11430832

TgeneAZU1

GO:0006508

proteolysis

21550830

TgeneAZU1

GO:0008347

glial cell migration

12465046

TgeneAZU1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24008408

TgeneAZU1

GO:0042535

positive regulation of tumor necrosis factor biosynthetic process

12465046

TgeneAZU1

GO:0045785

positive regulation of cell adhesion

12826073|15879141

TgeneAZU1

GO:0045860

positive regulation of protein kinase activity

24008408

TgeneAZU1

GO:0050725

positive regulation of interleukin-1 beta biosynthetic process

12465046

TgeneAZU1

GO:0050754

positive regulation of fractalkine biosynthetic process

12465046

TgeneAZU1

GO:0050766

positive regulation of phagocytosis

12465046

TgeneAZU1

GO:0070944

neutrophil mediated killing of bacterium

2312733


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-RL-AAAS-01ASTK11chr19

1207202

+AZU1chr19

828230

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000585748ENST00000233997STK11chr19

1207202

+AZU1chr19

828230

+
Frame-shitENST00000326873ENST00000233997STK11chr19

1207202

+AZU1chr19

828230

+

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FusionProtFeatures for STK11_AZU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK11

Q15831

AZU1

P20160

Tumor suppressor serine/threonine-protein kinase thatcontrols the activity of AMP-activated protein kinase (AMPK)family members, thereby playing a role in various processes suchas cell metabolism, cell polarity, apoptosis and DNA damageresponse. Acts by phosphorylating the T-loop of AMPK familyproteins, thus promoting their activity: phosphorylates PRKAA1,PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2,SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53.Acts as a key upstream regulator of AMPK by mediatingphosphorylation and activation of AMPK catalytic subunits PRKAA1and PRKAA2 and thereby regulates processes including: inhibitionof signaling pathways that promote cell growth and proliferationwhen energy levels are low, glucose homeostasis in liver,activation of autophagy when cells undergo nutrient deprivation,and B-cell differentiation in the germinal center in response toDNA damage. Also acts as a regulator of cellular polarity byremodeling the actin cytoskeleton. Required for cortical neuronpolarization by mediating phosphorylation and activation of BRSK1and BRSK2, leading to axon initiation and specification. Involvedin DNA damage response: interacts with p53/TP53 and recruited tothe CDKN1A/WAF1 promoter to participate in transcriptionactivation. Able to phosphorylate p53/TP53; the relevance of suchresult in vivo is however unclear and phosphorylation may beindirect and mediated by downstream STK11/LKB1 kinase NUAK1. Alsoacts as a mediator of p53/TP53-dependent apoptosis via interactionwith p53/TP53: translocates to the mitochondrion during apoptosisand regulates p53/TP53-dependent apoptosis pathways. In veinendothelial cells, inhibits PI3K/Akt signaling activity and thusinduces apoptosis in response to the oxidant peroxynitrite (invitro). Regulates UV radiation-induced DNA damage responsemediated by CDKN1A. In association with NUAK1, phosphorylatesCDKN1A in response to UV radiation and contributes to itsdegradation which is necessary for optimal DNA repair(PubMed:25329316). {ECO:0000269|PubMed:11430832,ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248,ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379,ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703,ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:18321849,ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. Isoform 2: Has a role in spermiogenesis. {ECO:0000250}. This is a neutrophil granule-derived antibacterial andmonocyte- and fibroblast-specific chemotactic glycoprotein. Bindsheparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strongaffinity of the very basic N-terminal half for the negativelycharged lipopolysaccharides that are unique to the Gram-negativebacterial outer envelope. It may play a role in mediatingrecruitment of monocytes in the second wave of inflammation. Hasantibacterial activity against the Gram-nagative bacteriumP.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.Acting alone, it does not have antimicrobial activity against theGram-negative bacteria A.actinomycetemcomitans ATCC 29532,A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4,H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872or E.coli ML-35. Has antibacterial activity against C.sputigenaATCC 33123 when acting synergistically with either elastase orcathepsin G. {ECO:0000269|PubMed:1399008,ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2312733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STK11_AZU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STK11_AZU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK11CAB39, STRADA, SMARCA4, STK11IP, TP53, WDR48, FKBP5, STRADB, CAB39L, CDC37, HSP90AA1, MARK4, HSPA1A, RPAP3, USP11, LIMS1, KIF23, SMARCC1, GSK3B, MARK2, SIK1, STUB1, UBE2D2, TNIP2, APP, SNRK, AP2M1, EIF2B1, ETV4, TP63, SIRT1, PRKAA1, SPDEF, MAPRE1, CCDC136, COPS3, COPS4, H2AFX, WDR6, BCAS3, CYP17A1, KLK7, LYPD3, NAT2, RHOBTB2, S100A14, SERPINB5, ST14, THRSP, TRIM25, PRSS50, ADIPOR1, ARG2, CALM2, CFL2, CRY2, CTSB, D2HGDH, EEF1A2, ERLEC1, FAIM2, GNPDA1, ND2, MOCS2, PDXP, PHF23, PLD3, SEPT9, STK24, THOP1, TSG101, TUBA1A, TUBB4A, VPS72, TBC1D23, RPS6KB1, PRKAA2, HERC2, KDM4A, HSP90AA4P, HSP90AB3P, PIP4K2A, HSP90AB4P, C5orf24, HSP90AA5P, HSP90AB1, FAM175B, DVL2, IVD, NEMF, CSNK2A1, MAP2K1AZU1CLEC4G, RAD21, ZYG11B, SH3GL2, SH3GL1, ERBB2IP, KBTBD6, BIN3, CBWD3, OSBPL6, STAT3, DIEXF, FBXO2, FIGNL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STK11_AZU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STK11_AZU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTK11C0031269Peutz-Jeghers Syndrome7CTD_human;ORPHANET;UNIPROT
HgeneSTK11C1336708Testicular Germ Cell Tumor3CTD_human;UNIPROT
HgeneSTK11C0001418Adenocarcinoma1CTD_human
HgeneSTK11C0007137Squamous cell carcinoma1CTD_human
HgeneSTK11C0020538Hypertensive disease1CTD_human
HgeneSTK11C0024121Lung Neoplasms1CTD_human
HgeneSTK11C0030297Pancreatic Neoplasm1CTD_human;HPO
HgeneSTK11C0149721Left Ventricular Hypertrophy1CTD_human
HgeneSTK11C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneSTK11C1257915Intestinal Polyposis1CTD_human