FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36473

FusionGeneSummary for STK10_SNX2

check button Fusion gene summary
Fusion gene informationFusion gene name: STK10_SNX2
Fusion gene ID: 36473
HgeneTgene
Gene symbol

STK10

SNX2

Gene ID

6793

6643

Gene nameserine/threonine kinase 10sorting nexin 2
SynonymsLOK|PRO2729TRG-9
Cytomap

5q35.1

5q23.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase 10lymphocyte-oriented kinasesorting nexin-2CTB-36H16.2transformation-related gene 9 protein
Modification date2018052320180523
UniProtAcc

O94804

O60749

Ensembl transtripts involved in fusion geneENST00000176763, ENST00000517775, 
ENST00000379516, ENST00000514949, 
ENST00000510372, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 4 X 4=48
# samples 64
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STK10 [Title/Abstract] AND SNX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK10

GO:0046777

protein autophosphorylation

12639966|18239682

TgeneSNX2

GO:0051259

protein complex oligomerization

9819414

TgeneSNX2

GO:0072673

lamellipodium morphogenesis

20604901


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0HL-01ASTK10chr5

171614891

-SNX2chr5

122161745

+
TCGALDLAMLTCGA-AB-2875-03ASTK10chr5

171509329

-SNX2chr5

122153043

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000176763ENST00000379516STK10chr5

171614891

-SNX2chr5

122161745

+
In-frameENST00000176763ENST00000514949STK10chr5

171614891

-SNX2chr5

122161745

+
5CDS-3UTRENST00000176763ENST00000510372STK10chr5

171614891

-SNX2chr5

122161745

+
intron-3CDSENST00000517775ENST00000379516STK10chr5

171614891

-SNX2chr5

122161745

+
intron-3CDSENST00000517775ENST00000514949STK10chr5

171614891

-SNX2chr5

122161745

+
intron-3UTRENST00000517775ENST00000510372STK10chr5

171614891

-SNX2chr5

122161745

+
In-frameENST00000176763ENST00000379516STK10chr5

171509329

-SNX2chr5

122153043

+
In-frameENST00000176763ENST00000514949STK10chr5

171509329

-SNX2chr5

122153043

+
5CDS-3UTRENST00000176763ENST00000510372STK10chr5

171509329

-SNX2chr5

122153043

+
intron-3CDSENST00000517775ENST00000379516STK10chr5

171509329

-SNX2chr5

122153043

+
intron-3CDSENST00000517775ENST00000514949STK10chr5

171509329

-SNX2chr5

122153043

+
intron-3UTRENST00000517775ENST00000510372STK10chr5

171509329

-SNX2chr5

122153043

+

Top

FusionProtFeatures for STK10_SNX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK10

O94804

SNX2

O60749

Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK10chr5:171509329chr5:122153043ENST00000176763-121936_294663969DomainProtein kinase
HgeneSTK10chr5:171509329chr5:122153043ENST00000176763-121942_50663969Nucleotide bindingATP
HgeneSTK10chr5:171614891chr5:122161745ENST00000176763-11942_5052969Nucleotide bindingATP
HgeneSTK10chr5:171509329chr5:122153043ENST00000176763-1219175_224663969RegionNote=Activation segment
TgeneSNX2chr5:171509329chr5:122153043ENST00000379516+015140_269-36520DomainPX
TgeneSNX2chr5:171509329chr5:122153043ENST00000379516+015299_519-36520DomainBAR
TgeneSNX2chr5:171509329chr5:122153043ENST00000379516+015278_295-36520RegionMembrane-binding amphipathic helix

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK10chr5:171509329chr5:122153043ENST00000176763-1219573_947663969Coiled coilOntology_term=ECO:0000255
HgeneSTK10chr5:171614891chr5:122161745ENST00000176763-119573_94752969Coiled coilOntology_term=ECO:0000255
HgeneSTK10chr5:171509329chr5:122153043ENST00000176763-1219750_884663969Compositional biasNote=Gln-rich
HgeneSTK10chr5:171614891chr5:122161745ENST00000176763-119750_88452969Compositional biasNote=Gln-rich
HgeneSTK10chr5:171614891chr5:122161745ENST00000176763-11936_29452969DomainProtein kinase
HgeneSTK10chr5:171614891chr5:122161745ENST00000176763-119175_22452969RegionNote=Activation segment
TgeneSNX2chr5:171614891chr5:122161745ENST00000379516+1015140_269404520DomainPX
TgeneSNX2chr5:171614891chr5:122161745ENST00000379516+1015299_519404520DomainBAR
TgeneSNX2chr5:171614891chr5:122161745ENST00000379516+1015278_295404520RegionMembrane-binding amphipathic helix


Top

FusionGeneSequence for STK10_SNX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000379516_chr5_122161745_+_168aa
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDK

>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000514949_chr5_122161745_+_168aa
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDK

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000379516_chr5_122153043_+_879aa
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH
PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDF
LKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE
SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQS
RPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV
SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQD
HAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALS
RALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIR

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000514949_chr5_122153043_+_879aa
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDH
PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDF
LKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE
SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQS
RPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV
SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQD
HAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALS
RALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000379516_chr5_122161745_+_504nt
ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG
GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGGTGTGTTTGACCATCGAATGAAG
TGCTGGCAGAAATGGGAAGATGCTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAA
ATACAGCAAGCTAAAAATGAAATAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGA
AAAGAAGTGGGAAGATTTGAGAAAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAA

>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000514949_chr5_122161745_+_504nt
ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG
GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGGTGTGTTTGACCATCGAATGAAG
TGCTGGCAGAAATGGGAAGATGCTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAA
ATACAGCAAGCTAAAAATGAAATAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGA
AAAGAAGTGGGAAGATTTGAGAAAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAA

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000379516_chr5_122153043_+_2637nt
ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG
GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCT
TTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCAC
CCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCC
ATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGC
AAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCC
AAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAA
GACACGCCCTACGACTACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTC
AACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTC
CTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAAC
AAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCC
GTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAG
TCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACC
ACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCC
AGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGC
CGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCT
TCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAA
GAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTG
AGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGG
CTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAG
GAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGAC
CATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATG
AAGAAAGAGTGGTTTGAAGAAAAGCAGCAGCAATTTGAGAATCTGGATCAGCAACTTAGGAAACTTCATGTCAGTGTTGAAGCCTTGGTC
TGTCATAGAAAAGAACTTTCAGCCAACACAGCTGCCTTTGCTAAAAGTGCTGCCATGTTAGGTAATTCTGAGGATCATACTGCTTTATCT
AGAGCTTTGTCTCAGCTTGCAGAGGTTGAGGAGAAGATAGACCAGTTACATCAAGAACAAGCTTTTGCTGACTTTTATATGTTTTCAGAA
CTACTTAGTGACTACATTCGTCTTATTGCTGCAGTGAAAGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGGAAGATGCTCAA
ATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAAATGAAATAAGA
GAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGATTTGAGAAAGAA
CGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACTGGGAAGCATTC

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000514949_chr5_122153043_+_2637nt
ATGGCTTTTGCCAATTTCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTG
GACCCCAACGAGGTGTGGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCT
TTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCAC
CCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCC
ATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGC
AAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCC
AAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAA
GACACGCCCTACGACTACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTC
AACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTC
CTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAAC
AAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCC
GTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAG
TCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACC
ACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCC
AGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGC
CGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCT
TCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAA
GAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTG
AGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGG
CTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAG
GAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGAC
CATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATG
AAGAAAGAGTGGTTTGAAGAAAAGCAGCAGCAATTTGAGAATCTGGATCAGCAACTTAGGAAACTTCATGTCAGTGTTGAAGCCTTGGTC
TGTCATAGAAAAGAACTTTCAGCCAACACAGCTGCCTTTGCTAAAAGTGCTGCCATGTTAGGTAATTCTGAGGATCATACTGCTTTATCT
AGAGCTTTGTCTCAGCTTGCAGAGGTTGAGGAGAAGATAGACCAGTTACATCAAGAACAAGCTTTTGCTGACTTTTATATGTTTTCAGAA
CTACTTAGTGACTACATTCGTCTTATTGCTGCAGTGAAAGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGGAAGATGCTCAA
ATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAAATGAAATAAGA
GAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGATTTGAGAAAGAA
CGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACTGGGAAGCATTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000379516_chr5_122161745_+_1308nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGG
AAGATGCTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAA
ATGAAATAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGAT
TTGAGAAAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACT
GGGAAGCATTCCTACCTGAAGCCAAAGCCATTGCCTAGCAATAAGATTGTTGCCGTTAAGAAGACCTTGGATGTTGTTCCAGTTATGCTG
GATTCCACAGTGAAATCATTTAAAACCATCTAAATAAACCACTATATATTTTATGAATTACATGTGGTTTTATATACACACACACACACA
CACACACACACACACACACACTCTGACATTTTATTACAAGCTGCATGTCCTGACCCTCTTTGAATTAAGTGGACTGTGGCATGACATTCT
GCAATACTTTGCTGAATTGAACACTATTGTGTCTTAAATACTTGCACTAAATAGTGCACTGCAAGACCAGAAAATTTTACAATATTTTTT
CTTTACAATATGTTCTGTAGTATGTTTACCCTCTTTATGAAGTGAATTACCAATGCTTTGAATAATGTTCACTTATACATTCCTGTACAG

>In-frame_STK10_ENST00000176763_chr5_171614891_-_SNX2_ENST00000514949_chr5_122161745_+_955nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGG
AAGATGCTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAA
ATGAAATAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGAT
TTGAGAAAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACT
GGGAAGCATTCCTACCTGAAGCCAAAGCCATTGCCTAGCAATAAGATTGTTGCCGTTAAGAAGACCTTGGATGTTGTTCCAGTTATGCTG

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000379516_chr5_122153043_+_3372nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG
TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC
TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGG
ACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACC
GAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTC
TACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACT
ACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCC
TGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGG
ATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGC
TGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCA
CCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGC
TGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCG
TGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCC
AGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCG
CCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGG
ACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGT
CCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCA
AGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAG
AGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGA
AGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCC
GGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGAAGCCT
TGGTCTGTCATAGAAAAGAACTTTCAGCCAACACAGCTGCCTTTGCTAAAAGTGCTGCCATGTTAGGTAATTCTGAGGATCATACTGCTT
TATCTAGAGCTTTGTCTCAGCTTGCAGAGGTTGAGGAGAAGATAGACCAGTTACATCAAGAACAAGCTTTTGCTGACTTTTATATGTTTT
CAGAACTACTTAGTGACTACATTCGTCTTATTGCTGCAGTGAAAGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGGAAGATG
CTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAAATGAAA
TAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGATTTGAGA
AAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACTGGGAAG
CATTCCTACCTGAAGCCAAAGCCATTGCCTAGCAATAAGATTGTTGCCGTTAAGAAGACCTTGGATGTTGTTCCAGTTATGCTGGATTCC
ACAGTGAAATCATTTAAAACCATCTAAATAAACCACTATATATTTTATGAATTACATGTGGTTTTATATACACACACACACACACACACA
CACACACACACACACTCTGACATTTTATTACAAGCTGCATGTCCTGACCCTCTTTGAATTAAGTGGACTGTGGCATGACATTCTGCAATA
CTTTGCTGAATTGAACACTATTGTGTCTTAAATACTTGCACTAAATAGTGCACTGCAAGACCAGAAAATTTTACAATATTTTTTCTTTAC
AATATGTTCTGTAGTATGTTTACCCTCTTTATGAAGTGAATTACCAATGCTTTGAATAATGTTCACTTATACATTCCTGTACAGAAATTA

>In-frame_STK10_ENST00000176763_chr5_171509329_-_SNX2_ENST00000514949_chr5_122153043_+_3019nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG
TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC
TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGG
ACAGAGGCCTCACGGAGCCCCAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACC
GAGATCTGAAAGCTGGCAACGTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTC
TACAGAAACGAGATTCCTTCATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACT
ACAAAGCCGACATCTGGTCCCTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCC
TGCTAAAGATCGCCAAGTCGGACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGG
ATAAGAACCCAGAAACCCGACCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGC
TGGTGGCTGAGGCCAAGGCCGAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCA
CCCTGGAGAACCATACTCAGAACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGC
TGGCACCCAGCCAGTCTCAGGACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCG
TGGCCCCTGGAAATGAGAACGGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCC
AGGAGAAGCAAGTTGCTGAGCAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCG
CCCTGGAGACCTTGGGTGGGGAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGG
ACTGCAGCAGCCTCTGCACCTCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGT
CCATCAAGGACCCGAAACTGTACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCA
AGATCATCAGCGAAGATGAGAAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAG
AGCATCGGAACCAGACCCAGCTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGA
AGAAGTTCTTTGACACGGAATTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCC
GGGAGGAGGCCAGGCGGATCCGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGAAGCCT
TGGTCTGTCATAGAAAAGAACTTTCAGCCAACACAGCTGCCTTTGCTAAAAGTGCTGCCATGTTAGGTAATTCTGAGGATCATACTGCTT
TATCTAGAGCTTTGTCTCAGCTTGCAGAGGTTGAGGAGAAGATAGACCAGTTACATCAAGAACAAGCTTTTGCTGACTTTTATATGTTTT
CAGAACTACTTAGTGACTACATTCGTCTTATTGCTGCAGTGAAAGGTGTGTTTGACCATCGAATGAAGTGCTGGCAGAAATGGGAAGATG
CTCAAATTACTTTGCTCAAAAAACGTGAAGCTGAAGCAAAAATGATGGTTGCTAACAAACCAGATAAAATACAGCAAGCTAAAAATGAAA
TAAGAGAGTGGGAGGCGAAAGTGCAACAAGGGGAAAGAGATTTTGAACAGATATCTAAAACGATTCGAAAAGAAGTGGGAAGATTTGAGA
AAGAACGAGTGAAGGATTTTAAAACCGTTATCATCAAGTACTTAGAATCACTAGTTCAAACACAACAACAGCTGATAAAATACTGGGAAG
CATTCCTACCTGAAGCCAAAGCCATTGCCTAGCAATAAGATTGTTGCCGTTAAGAAGACCTTGGATGTTGTTCCAGTTATGCTGGATTCC


Top

FusionGenePPI for STK10_SNX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STK10CD81, ENO1, SHMT2, MOV10, NXF1, KIFC1, XPO1, TRIM25SNX2FNBP1, SNX6, ACVR2B, ACVR1B, SNX1, PDGFRA, PDGFRB, SNX4, EGFR, INSR, LEPR, VPS29, VPS35, NFYC, LAMC1, C1orf122, CSNK2B, SNX5, ZNF202, DUSP10, PAK6, H3F3A, HIRIP3, ANP32E, ATG7, ATP6V1C1, CTTN, FAM129B, GSPT1, GSPT2, PAWR, RDX, SHMT1, STAT1, TBC1D15, TBCD, CCDC8, USP46, FAM221A, SFXN2, C11orf42, DNM3, GNAT2, TREML2, FAM90A1, CYP1A1, GATS, VAPB, CTPS1, DDB1, HGS, IMPDH2, PDXK, PPAT, RNF40, RUVBL2, ASUN, ENOPH1, ERC1, ERP44, MAN2B1, NCBP1, PCID2, RTN4, WDFY1, TSN, VPS26A, VPS26B, NTRK1, KRAS, TMEM17, FOXL1, CDC5L, CDH1, C1orf87, POTEB3, HENMT1, TCTEX1D2, SNX32, TRIM17, CYB5A, DLD, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSNX2chr5:171509329chr5:122153043ENST00000379516+015260_519-36520RhoG


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSNX2chr5:171614891chr5:122161745ENST00000379516+1015260_519404520RhoG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STK10_SNX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STK10_SNX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTK10C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSTK10C1336708Testicular Germ Cell Tumor1UNIPROT