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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36446

FusionGeneSummary for STEAP4_CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: STEAP4_CTNND1
Fusion gene ID: 36446
HgeneTgene
Gene symbol

STEAP4

CTNND1

Gene ID

79689

1500

Gene nameSTEAP4 metalloreductasecatenin delta 1
SynonymsSTAMP2|SchLAH|TIARP|TNFAIP9BCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)
Cytomap

7q21.12

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionmetalloreductase STEAP4STEAP family member 4seven chromosome locus associated with HCCsix transmembrane prostate protein 2six-transmembrane epithelial antigen of prostate 4sixTransMembrane protein of prostate 2tumor necrosis factor, alpha-induced prcatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenin
Modification date2018052320180523
UniProtAcc

Q687X5

O60716

Ensembl transtripts involved in fusion geneENST00000380079, ENST00000301959, 
ENST00000414498, 
ENST00000524630, 
ENST00000529919, ENST00000399039, 
ENST00000360682, ENST00000361796, 
ENST00000361391, ENST00000530094, 
ENST00000428599, ENST00000361332, 
ENST00000527467, ENST00000415361, 
ENST00000532245, ENST00000532463, 
ENST00000528232, ENST00000529986, 
ENST00000531014, ENST00000358694, 
ENST00000526772, ENST00000532787, 
ENST00000533667, ENST00000529873, 
ENST00000525902, ENST00000529526, 
ENST00000532649, ENST00000426142, 
ENST00000532844, ENST00000528621, 
ENST00000399050, ENST00000526357, 
ENST00000530748, ENST00000534579, 
ENST00000526938, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 7 X 5=280
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STEAP4 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF987948STEAP4chr7

87912372

-CTNND1chr11

57569332

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380079ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000380079ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000301959ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000524630STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529919STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000399039STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000360682STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361796STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361391STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000530094STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000428599STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000361332STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000527467STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000415361STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532245STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532463STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000528232STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529986STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000531014STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000358694STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526772STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532787STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000533667STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529873STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000525902STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000529526STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532649STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000426142STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000532844STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000528621STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000399050STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526357STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000530748STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000534579STEAP4chr7

87912372

-CTNND1chr11

57569332

+
intron-3CDSENST00000414498ENST00000526938STEAP4chr7

87912372

-CTNND1chr11

57569332

+

Top

FusionProtFeatures for STEAP4_CTNND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STEAP4

Q687X5

CTNND1

O60716

Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). UsesNADP(+) as acceptor (By similarity). Plays a role in systemicmetabolic homeostasis, integrating inflammatory and metabolicresponses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved ininflammatory arthritis, through the regulation of inflammatorycytokines (PubMed:19660107). Inhibits anchorage-independent cellproliferation (PubMed:19787193). {ECO:0000250,ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367,ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STEAP4_CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STEAP4_CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STEAP4_CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STEAP4_CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTEAP4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSTEAP4C0033578Prostatic Neoplasms1CTD_human