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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36442

FusionGeneSummary for STEAP3_PTK7

check button Fusion gene summary
Fusion gene informationFusion gene name: STEAP3_PTK7
Fusion gene ID: 36442
HgeneTgene
Gene symbol

STEAP3

PTK7

Gene ID

55240

5754

Gene nameSTEAP3 metalloreductaseprotein tyrosine kinase 7 (inactive)
SynonymsAHMIO2|STMP3|TSAP6|dudlin-2|dudulin-2|pHydeCCK-4|CCK4
Cytomap

2q14.2

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionmetalloreductase STEAP3STEAP family member 3, metalloreductasesix-transmembrane epithelial antigen of prostate 3tumor suppressor pHydetumor suppressor-activated pathway protein 6inactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7
Modification date2018052320180523
UniProtAcc

Q658P3

Q13308

Ensembl transtripts involved in fusion geneENST00000450943, ENST00000354888, 
ENST00000393108, ENST00000393110, 
ENST00000393106, ENST00000393107, 
ENST00000409811, ENST00000425223, 
ENST00000230419, ENST00000349241, 
ENST00000345201, ENST00000352931, 
ENST00000481273, ENST00000476760, 
ENST00000471863, 
Fusion gene scores* DoF score6 X 5 X 1=305 X 5 X 3=75
# samples 96
** MAII scorelog2(9/30*10)=1.58496250072116
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STEAP3 [Title/Abstract] AND PTK7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTEAP3

GO:0009306

protein secretion

15319436


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP288114STEAP3chr2

120003550

+PTK7chr6

43100233

+
ChiTaRS3.1BP287506STEAP3chr2

120003550

+PTK7chr6

43100233

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000450943ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000450943ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000450943ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000450943ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000450943ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000450943ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000450943ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000354888ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000354888ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000354888ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000354888ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000354888ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000354888ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000354888ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393108ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393108ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393108ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393108ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393108ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393108ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393108ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393110ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393110ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393110ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393110ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393110ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393110ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393110ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393106ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393106ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393106ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393106ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393106ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393106ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393106ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393107ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393107ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393107ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393107ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000393107ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393107ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000393107ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000409811ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000409811ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000409811ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000409811ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000409811ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000409811ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000409811ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000425223ENST00000230419STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000425223ENST00000349241STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000425223ENST00000345201STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000425223ENST00000352931STEAP3chr2

120003550

+PTK7chr6

43100233

+
Frame-shitENST00000425223ENST00000481273STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000425223ENST00000476760STEAP3chr2

120003550

+PTK7chr6

43100233

+
5CDS-intronENST00000425223ENST00000471863STEAP3chr2

120003550

+PTK7chr6

43100233

+

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FusionProtFeatures for STEAP3_PTK7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STEAP3

Q658P3

PTK7

Q13308


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STEAP3_PTK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STEAP3_PTK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STEAP3_PTK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STEAP3_PTK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource