	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 36442

FusionGeneSummary for STEAP3_PTK7

Fusion gene summary

Fusion gene information	Fusion gene name: STEAP3_PTK7
	Fusion gene ID: 36442
		Hgene	Tgene
	Gene symbol	STEAP3	PTK7
	Gene ID	55240	5754
	Gene name	STEAP3 metalloreductase	protein tyrosine kinase 7 (inactive)
	Synonyms	AHMIO2\|STMP3\|TSAP6\|dudlin-2\|dudulin-2\|pHyde	CCK-4\|CCK4
	Cytomap	2q14.2	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	metalloreductase STEAP3STEAP family member 3, metalloreductasesix-transmembrane epithelial antigen of prostate 3tumor suppressor pHydetumor suppressor-activated pathway protein 6	inactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7
	Modification date	20180523	20180523
	UniProtAcc	Q658P3	Q13308
	Ensembl transtripts involved in fusion gene	ENST00000450943, ENST00000354888, ENST00000393108, ENST00000393110, ENST00000393106, ENST00000393107, ENST00000409811, ENST00000425223,	ENST00000230419, ENST00000349241, ENST00000345201, ENST00000352931, ENST00000481273, ENST00000476760, ENST00000471863,
Fusion gene scores	* DoF score	6 X 5 X 1=30	5 X 5 X 3=75
	# samples	9	6
	** MAII score	log2(9/30*10)=1.58496250072116 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STEAP3 [Title/Abstract] AND PTK7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STEAP3	GO:0009306	protein secretion	15319436

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BP288114	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
ChiTaRS3.1			BP287506	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000450943	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000450943	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000450943	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000450943	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000450943	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000450943	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000450943	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000354888	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000354888	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000354888	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000354888	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000354888	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000354888	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000354888	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393108	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393108	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393108	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393108	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393108	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393108	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393108	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393110	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393110	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393110	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393110	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393110	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393110	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393110	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393106	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393106	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393106	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393106	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393106	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393106	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393106	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393107	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393107	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393107	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393107	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000393107	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393107	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000393107	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000409811	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000409811	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000409811	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000409811	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000409811	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000409811	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000409811	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000425223	ENST00000230419	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000425223	ENST00000349241	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000425223	ENST00000345201	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000425223	ENST00000352931	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
Frame-shift	ENST00000425223	ENST00000481273	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000425223	ENST00000476760	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+
5CDS-intron	ENST00000425223	ENST00000471863	STEAP3	chr2	120003550	+	PTK7	chr6	43100233	+

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FusionProtFeatures for STEAP3_PTK7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
STEAP3 Q658P3	PTK7 Q13308

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for STEAP3_PTK7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STEAP3_PTK7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for STEAP3_PTK7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for STEAP3_PTK7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 36442

FusionGeneSummary for STEAP3_PTK7

FusionProtFeatures for STEAP3_PTK7

FusionGeneSequence for STEAP3_PTK7

FusionGenePPI for STEAP3_PTK7

RelatedDrugs for STEAP3_PTK7

RelatedDiseases for STEAP3_PTK7