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Fusion gene ID: 36437 |
FusionGeneSummary for STEAP2_PDCD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STEAP2_PDCD4 | Fusion gene ID: 36437 | Hgene | Tgene | Gene symbol | STEAP2 | PDCD4 | Gene ID | 261729 | 27250 |
| Gene name | STEAP2 metalloreductase | programmed cell death 4 | |
| Synonyms | IPCA1|PCANAP1|PUMPCn|STAMP1|STMP | H731 | |
| Cytomap | 7q21.13 | 10q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metalloreductase STEAP2STEAP family member 2, metalloreductaseSixTransMembrane Protein of Prostate 1prostate cancer-associated protein 1protein up-regulated in metastatic prostate cancerprotein upregulated in metastatic prostate cancersix transmembr | programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q8NFT2 | Q53EL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000287908, ENST00000394626, ENST00000394622, ENST00000394632, ENST00000394621, ENST00000402625, ENST00000394629, | ENST00000280154, ENST00000393104, ENST00000481353, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 3 X 2=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/50*10)=0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STEAP2 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STEAP2 | GO:0006893 | Golgi to plasma membrane transport | 12095985 |
| Hgene | STEAP2 | GO:0006897 | endocytosis | 12095985 |
| Hgene | STEAP2 | GO:0009725 | response to hormone | 12095985 |
| Hgene | STEAP2 | GO:0045055 | regulated exocytosis | 12095985 |
| Tgene | PDCD4 | GO:0007569 | cell aging | 12054647 |
| Tgene | PDCD4 | GO:0030509 | BMP signaling pathway | 18548003 |
| Tgene | PDCD4 | GO:0045892 | negative regulation of transcription, DNA-templated | 16357133 |
| Tgene | PDCD4 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | 18548003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AY008445 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000287908 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| 3UTR-3UTR | ENST00000287908 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| 3UTR-intron | ENST00000287908 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394626 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394626 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-intron | ENST00000394626 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| 3UTR-3UTR | ENST00000394622 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| 3UTR-3UTR | ENST00000394622 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| 3UTR-intron | ENST00000394622 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394632 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394632 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-intron | ENST00000394632 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394621 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394621 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-intron | ENST00000394621 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000402625 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000402625 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-intron | ENST00000402625 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394629 | ENST00000280154 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-3UTR | ENST00000394629 | ENST00000393104 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
| intron-intron | ENST00000394629 | ENST00000481353 | STEAP2 | chr7 | 89863908 | + | PDCD4 | chr10 | 112659513 | + |
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FusionProtFeatures for STEAP2_PDCD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STEAP2 | PDCD4 |
| Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (Bysimilarity). {ECO:0000250}. | Inhibits translation initiation and cap-dependenttranslation. May excert its function by hindering the interactionbetween EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.Modulates the activation of JUN kinase. Down-regulates theexpression of MAP4K1, thus inhibiting events important in drivinginvasion, namely, MAPK85 activation and consequent JUN-dependenttranscription. May play a role in apoptosis. Tumor suppressor.Inhibits tumor promoter-induced neoplastic transformation. BindsRNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133,ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147,ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607,ECO:0000269|PubMed:19204291}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STEAP2_PDCD4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STEAP2_PDCD4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STEAP2_PDCD4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STEAP2_PDCD4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDCD4 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
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