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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36435

FusionGeneSummary for STEAP2_COL6A2

check button Fusion gene summary
Fusion gene informationFusion gene name: STEAP2_COL6A2
Fusion gene ID: 36435
HgeneTgene
Gene symbol

STEAP2

COL6A2

Gene ID

261729

1292

Gene nameSTEAP2 metalloreductasecollagen type VI alpha 2 chain
SynonymsIPCA1|PCANAP1|PUMPCn|STAMP1|STMPBTHLM1|PP3610|UCMD1
Cytomap

7q21.13

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionmetalloreductase STEAP2STEAP family member 2, metalloreductaseSixTransMembrane Protein of Prostate 1prostate cancer-associated protein 1protein up-regulated in metastatic prostate cancerprotein upregulated in metastatic prostate cancersix transmembrcollagen alpha-2(VI) chaincollagen VI, alpha-2 polypeptidecollagen, type VI, alpha 2human mRNA for collagen VI alpha-2 C-terminal globular domain
Modification date2018052320180523
UniProtAcc

Q8NFT2

P12110

Ensembl transtripts involved in fusion geneENST00000287908, ENST00000394626, 
ENST00000394622, ENST00000394632, 
ENST00000394621, ENST00000402625, 
ENST00000394629, 		ENST00000300527, 
ENST00000310645, ENST00000357838, 
ENST00000409416, ENST00000397763, 
ENST00000460886, 
Fusion gene scores* DoF score5 X 5 X 2=508 X 7 X 3=168
# samples 58
** MAII scorelog2(5/50*10)=0log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STEAP2 [Title/Abstract] AND COL6A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTEAP2

GO:0006893

Golgi to plasma membrane transport

12095985

HgeneSTEAP2

GO:0006897

endocytosis

12095985

HgeneSTEAP2

GO:0009725

response to hormone

12095985

HgeneSTEAP2

GO:0045055

regulated exocytosis

12095985


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA568273STEAP2chr7

89865111

+COL6A2chr21

47545844

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000287908ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000287908ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000287908ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000287908ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000287908ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-intronENST00000287908ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394626ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394626ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394626ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394626ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394626ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-intronENST00000394626ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000394622ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000394622ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000394622ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000394622ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-3CDSENST00000394622ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
3UTR-intronENST00000394622ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394632ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394632ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394632ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394632ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394632ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-intronENST00000394632ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394621ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394621ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394621ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394621ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394621ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-intronENST00000394621ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000402625ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000402625ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000402625ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000402625ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000402625ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-intronENST00000402625ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394629ENST00000300527STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394629ENST00000310645STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394629ENST00000357838STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394629ENST00000409416STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-3CDSENST00000394629ENST00000397763STEAP2chr7

89865111

+COL6A2chr21

47545844

+
intron-intronENST00000394629ENST00000460886STEAP2chr7

89865111

+COL6A2chr21

47545844

+

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FusionProtFeatures for STEAP2_COL6A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STEAP2

Q8NFT2

COL6A2

P12110

Metalloreductase that has the ability to reduce bothFe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STEAP2_COL6A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STEAP2_COL6A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STEAP2_COL6A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STEAP2_COL6A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCOL6A2C1834674Bethlem myopathy4CTD_human;ORPHANET;UNIPROT
TgeneCOL6A2C0410179Scleroatonic muscular dystrophy2CTD_human;ORPHANET;UNIPROT
TgeneCOL6A2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCOL6A2C0029408Degenerative polyarthritis1CTD_human