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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36425

FusionGeneSummary for STAU2_OSBPL2

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU2_OSBPL2
Fusion gene ID: 36425
HgeneTgene
Gene symbol

STAU2

OSBPL2

Gene ID

27067

9885

Gene namestaufen double-stranded RNA binding protein 2oxysterol binding protein like 2
Synonyms39K2|39K3DFNA67|DNFA67|ORP-2|ORP2
Cytomap

8q21.11

20q13.33

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2oxysterol-binding protein-related protein 2OSBP-related protein 2
Modification date2018051920180523
UniProtAcc

Q9NUL3

Q9H1P3

Ensembl transtripts involved in fusion geneENST00000522695, ENST00000524300, 
ENST00000523558, ENST00000521210, 
ENST00000355780, ENST00000519961, 
ENST00000521727, ENST00000521451, 
ENST00000522509, ENST00000517542, 
ENST00000524104, ENST00000522962, 
ENST00000521419, 		ENST00000439951, 
ENST00000313733, ENST00000358053, 
ENST00000471817, 
Fusion gene scores* DoF score11 X 8 X 9=7926 X 5 X 5=150
# samples 137
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAU2 [Title/Abstract] AND OSBPL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EE-A2MH-06ASTAU2chr8

74507401

-OSBPL2chr20

60831113

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000522695ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000522695ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000522695ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000522695ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000524300ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000524300ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000524300ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000524300ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000523558ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000523558ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000523558ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000523558ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521210ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521210ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521210ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000521210ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000355780ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000355780ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000355780ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000355780ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000519961ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000519961ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000519961ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000519961ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521727ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521727ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521727ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000521727ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521451ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521451ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000521451ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000521451ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000522509ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000522509ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000522509ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000522509ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000517542ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000517542ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-5UTRENST00000517542ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
5CDS-intronENST00000517542ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000524104ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000524104ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000524104ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-intronENST00000524104ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000522962ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000522962ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000522962ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-intronENST00000522962ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000521419ENST00000439951STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000521419ENST00000313733STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-5UTRENST00000521419ENST00000358053STAU2chr8

74507401

-OSBPL2chr20

60831113

+
intron-intronENST00000521419ENST00000471817STAU2chr8

74507401

-OSBPL2chr20

60831113

+

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FusionProtFeatures for STAU2_OSBPL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAU2

Q9NUL3

OSBPL2

Q9H1P3

Binds phospholipids; exhibits strong binding tophosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds 25-hydroxycholesterol(PubMed:17428193). {ECO:0000269|PubMed:11279184,ECO:0000269|PubMed:17428193}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAU2_OSBPL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAU2_OSBPL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAU2KIAA1377, DHX58, EIF2AK2, ELAVL1, COPS5, DICER1, PRKRA, UPF1, ZNF346, ADAR, SHMT2, MOV10, NXF1, BMI1, HIST1H1A, RPL14, RPL8, RPL6, NIFK, RPS2, PRR11, RBM4B, ILF2, PAIP1, HNRNPU, MATR3, STRBP, STAU1, GLTSCR2, WDR46, ELAVL2, PPAN, ZCRB1, ZC3HAV1, E4F1, DGCR8, ZNF324B, NXF2, CDX1, RPL37A, ZNF169, HIST1H1E, RPF1, ZNF2, GPATCH4, G3BP1OSBPL2ELAVL1, VAPB, APBB2, HNRNPD, SGTB, BAG6, VAPA, ZFPL1, BIRC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAU2_OSBPL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAU2_OSBPL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAU2C0023893Liver Cirrhosis, Experimental1CTD_human