FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36423

FusionGeneSummary for STAU2_MTFR1

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU2_MTFR1
Fusion gene ID: 36423
HgeneTgene
Gene symbol

STAU2

MTFR1

Gene ID

27067

9650

Gene namestaufen double-stranded RNA binding protein 2mitochondrial fission regulator 1
Synonyms39K2|39K3CHPPR|FAM54A2
Cytomap

8q21.11

8q13.1

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 2staufen homolog 2staufen, RNA binding protein, homolog 2mitochondrial fission regulator 1chondrocyte protein with a poly-proline region
Modification date2018051920180523
UniProtAcc

Q9NUL3

Q15390

Ensembl transtripts involved in fusion geneENST00000522695, ENST00000524300, 
ENST00000523558, ENST00000521210, 
ENST00000355780, ENST00000519961, 
ENST00000521727, ENST00000521451, 
ENST00000522509, ENST00000517542, 
ENST00000524104, ENST00000522962, 
ENST00000521419, 		ENST00000262146, 
ENST00000517944, ENST00000458689, 
Fusion gene scores* DoF score11 X 8 X 9=7922 X 2 X 2=8
# samples 132
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: STAU2 [Title/Abstract] AND MTFR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XK-AAIV-01ASTAU2chr8

74650519

-MTFR1chr8

66631615

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000522695ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000522695ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000522695ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000524300ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000524300ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000524300ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000523558ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000523558ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000523558ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521210ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521210ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521210ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000355780ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000355780ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000355780ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000519961ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000519961ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000519961ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521727ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521727ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521727ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521451ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521451ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000521451ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000522509ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000522509ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000522509ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000517542ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000517542ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
intron-intronENST00000517542ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000524104ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000524104ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5CDS-intronENST00000524104ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000522962ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000522962ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000522962ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521419ENST00000262146STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521419ENST00000517944STAU2chr8

74650519

-MTFR1chr8

66631615

+
5UTR-intronENST00000521419ENST00000458689STAU2chr8

74650519

-MTFR1chr8

66631615

+

Top

FusionProtFeatures for STAU2_MTFR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAU2

Q9NUL3

MTFR1

Q15390

May play a role in mitochondrial aerobic respiration.May also regulate mitochondrial organization and fission (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STAU2_MTFR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STAU2_MTFR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAU2KIAA1377, DHX58, EIF2AK2, ELAVL1, COPS5, DICER1, PRKRA, UPF1, ZNF346, ADAR, SHMT2, MOV10, NXF1, BMI1, HIST1H1A, RPL14, RPL8, RPL6, NIFK, RPS2, PRR11, RBM4B, ILF2, PAIP1, HNRNPU, MATR3, STRBP, STAU1, GLTSCR2, WDR46, ELAVL2, PPAN, ZCRB1, ZC3HAV1, E4F1, DGCR8, ZNF324B, NXF2, CDX1, RPL37A, ZNF169, HIST1H1E, RPF1, ZNF2, GPATCH4, G3BP1MTFR1DUSP23, DICER1, ENO1, SHMT2, MOV10, NXF1, COLEC11, CENPO, CBWD1, CCDC151, FGL2, CAPZA2, MTM1, DIABLO, IL13RA2, CTAGE5, ATG14, CCDC120, P2RX5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STAU2_MTFR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STAU2_MTFR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAU2C0023893Liver Cirrhosis, Experimental1CTD_human