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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36416

FusionGeneSummary for STAU1_PABPC1L

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU1_PABPC1L
Fusion gene ID: 36416
HgeneTgene
Gene symbol

STAU1

PABPC1L

Gene ID

6780

80336

Gene namestaufen double-stranded RNA binding protein 1poly(A) binding protein cytoplasmic 1 like
SynonymsPPP1R150|STAUC20orf119|EPAB|PABPC1L1|dJ1069P2.3
Cytomap

20q13.13

20q13.12

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 1protein phosphatase 1, regulatory subunit 150staufen, RNA binding protein, homolog 1polyadenylate-binding protein 1-likeembryonic poly(A) binding protein
Modification date2018052220180523
UniProtAcc

O95793

Q4VXU2

Ensembl transtripts involved in fusion geneENST00000371828, ENST00000371802, 
ENST00000371856, ENST00000347458, 
ENST00000340954, ENST00000371792, 
ENST00000360426, 		ENST00000217074, 
ENST00000255136, ENST00000537323, 
ENST00000217073, ENST00000490798, 
ENST00000372824, ENST00000372819, 
ENST00000217075, 
Fusion gene scores* DoF score11 X 8 X 6=5285 X 5 X 4=100
# samples 145
** MAII scorelog2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAU1 [Title/Abstract] AND PABPC1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-IN-A6RL-01ASTAU1chr20

47790732

-PABPC1Lchr20

43545397

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000371828ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371828ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371828ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371828ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371828ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371828ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371828ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371828ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371802ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371802ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371802ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371802ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371802ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371802ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371802ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371802ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371856ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371856ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371856ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000371856ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371856ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371856ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371856ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000371856ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000347458ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000347458ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000347458ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000347458ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000347458ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000347458ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000347458ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000347458ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000340954ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000340954ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000340954ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000340954ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000340954ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000340954ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000340954ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000340954ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371792ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371792ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371792ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-3CDSENST00000371792ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371792ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371792ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371792ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
intron-intronENST00000371792ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000360426ENST00000217074STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000360426ENST00000255136STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000360426ENST00000537323STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-3CDSENST00000360426ENST00000217073STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000360426ENST00000490798STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000360426ENST00000372824STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000360426ENST00000372819STAU1chr20

47790732

-PABPC1Lchr20

43545397

+
5UTR-intronENST00000360426ENST00000217075STAU1chr20

47790732

-PABPC1Lchr20

43545397

+

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FusionProtFeatures for STAU1_PABPC1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAU1

O95793

PABPC1L

Q4VXU2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAU1_PABPC1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAU1_PABPC1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAU1DDX50, HNRNPU, ILF3, NCL, PABPC1, FMR1, DYNC1I1, TUBB3, KIF5A, TUBA1A, RPLP0, RPL6, RPS2, RPS6, RPS3A, RPL7A, RPS8, RPL14, RPL10, RPL15, RPL21, PPP1CA, DHX58, EIF2AK2, CSNK2B, UBE2D3, HDGF, ELAVL1, SIRT7, SPP1, CUL3, CUL1, CAND1, APP, ESR1, MDC1, PAXIP1, PPP1CC, ESR2, CBX8, SRPK3, SRPK1, TARDBP, GTPBP4, UPF1, ZNF622, FZR1, CDC20, IVNS1ABP, TAX1BP3, DHX9, EEF1A1, UPF3B, ABCE1, IGF2BP1, XPO1, ITIH4, HNRNPD, HNRNPM, TUBB, FASN, CLTC, STAU1, HSPA8, ACLY, IARS, COPA, MCM7, LRPPRC, VIM, HSPD1, CAD, HSPA1A, HSPA1B, TCP1, ATP5A1, ETFB, EIF4A1, KHSRP, ATP1A1, EPRS, DARS, RPL13, GNB2L1, PRKDC, PABPC4, SPTAN1, PRPF8, EIF3A, LARS, SNRNP200, LDHA, ENO1, HNRNPC, RPS3, KIF5B, RBMX, QARS, RARS, ACTB, ILF2, DHX15, RPN1, SLC25A5, CDK1, PYGL, LDHB, HNRNPA1, HSPA5, HK1, EEF1D, ATP5C1, RPL4, HSPA9, RPL3, RPL5, RPL8, SLC25A11, CAPRIN1, PTCD3, PHB2, DRG1, DDX3X, EIF3D, SRP72, TPR, PKM, DDX5, RPL7, RPL17, HNRNPA2B1, VARS, YWHAQ, ATP5O, NPEPPS, EIF3B, RPS4X, YBX1, ARF5, RPL19, RPL18, SF3B2, KPNB1, DHX30, DDX1, MOV10, DDX21, PSMD3, SART1, PRPF40A, SF3B1, TOMM70A, OAT, ATP5B, PFKL, HNRNPH1, GARS, RPS9, CCT4, YWHAZ, RPL24, SRSF1, GOLGA3, SMC1A, ZC3H15, GCN1L1, CYFIP2, DOCK7, MYBBP1A, SFXN1, FAM120A, SRP68, IPO5, IRS4, NUDT21, KIF1C, PRKRA, GAPDH, NPM1, FLNA, EEF1G, CANX, RPL9, PHB, DDOST, ARL1, MATR3, NSF, IDH3A, SERPINH1, HSD17B4, HNRNPA3, CSE1L, LYZ, HNRNPK, GOLGA2, HNRNPA0, TRIM28, PCBP1, SAFB, SF3B4, SRSF7, PABPN1, SCFD1, AP3S1, CDC5L, DDX23, COPG2, IGF2BP2, INA, CPSF1, DDX17, AIFM1, SFPQ, HNRNPR, NONO, ARF4, CPSF7, ALDH18A1, RAN, IQGAP1, ACSL3, ALYREF, THOC2, PSMC6, CDIPT, HNRNPH3, SYNCRIP, IGF2BP3, LRRC59, MOGS, NKRF, PTPLAD1, PDHB, SRPRB, DDX39B, SRSF10, PSMD2, RPL29, DHCR7, ARPC4, ARF6, COPZ1, RNF20, HNRNPF, HNRNPH2, KRR1, IPO7, NUP155, PRDX6, FIP1L1, DDX27, SEC61A1, LUC7L2, RAVER1, PLS3, ZFR, AP2M1, AP3D1, CPNE3, ADAR, DNM2, EIF4A3, EIF3E, HSPA1L, HNRNPAB, PTDSS1, RRAGA, RAB10, RAB5C, RAB8A, SRSF4, CCT2, TUBA4A, ATP6V0D1, SPRTN, GLRX3, NXT1, ZMAT3, LONRF1, CUL7, CCDC8, BMI1, HIST1H1A, NOL12, ZBTB38, PRR11, RBM4B, TINCR, NTRK1, IFI16, PCM1, CC2D2A, SCLT1, MCM2, POU5F1, RC3H1, CCNB1, FBXO11, NMNAT1, ELAVL4, RBM34, STAU2, RRP8, CNBP, RALY, MAGEB10, DDX31, KIAA0020, ZNF512, RRS1, RPL37A, WDR46, RPL30, HIST1H1E, RPL26L1, ZC3HAV1, GLYR1, RBM28, RPS14, BAAT, PPAN, RPL18A, PPAN-P2RY11, TARBP2, PLEKHO1, KNOP1, CPNE4, GPATCH4, BRIX1, FTSJ3, DKC1, CYLD, FOXA1, G3BP1, BRCA1PABPC1LPARK2, PAIP1, XPO1, CYLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAU1_PABPC1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAU1_PABPC1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource