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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36415

FusionGeneSummary for STAU1_MRPL4

check button Fusion gene summary
Fusion gene informationFusion gene name: STAU1_MRPL4
Fusion gene ID: 36415
HgeneTgene
Gene symbol

STAU1

MRPL4

Gene ID

6780

51073

Gene namestaufen double-stranded RNA binding protein 1mitochondrial ribosomal protein L4
SynonymsPPP1R150|STAUCGI-28|L4mt
Cytomap

20q13.13

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-binding protein Staufen homolog 1protein phosphatase 1, regulatory subunit 150staufen, RNA binding protein, homolog 139S ribosomal protein L4, mitochondrialMRP-L4mitochondrial large ribosomal subunit protein uL4m
Modification date2018052220180523
UniProtAcc

O95793

Q9BYD3

Ensembl transtripts involved in fusion geneENST00000371828, ENST00000371802, 
ENST00000371856, ENST00000347458, 
ENST00000340954, ENST00000371792, 
ENST00000360426, 		ENST00000307422, 
ENST00000253099, ENST00000590669, 
ENST00000393733, ENST00000588502, 
Fusion gene scores* DoF score11 X 8 X 6=5283 X 3 X 3=27
# samples 143
** MAII scorelog2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STAU1 [Title/Abstract] AND MRPL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AO-01ASTAU1chr20

47790732

-MRPL4chr19

10363073

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000371828ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371828ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371828ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371828ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371828ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371802ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371802ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371802ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371802ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371802ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371856ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371856ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371856ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371856ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000371856ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000347458ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000347458ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000347458ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000347458ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000347458ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000340954ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000340954ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000340954ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000340954ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000340954ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371792ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371792ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371792ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371792ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
intron-3CDSENST00000371792ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000360426ENST00000307422STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000360426ENST00000253099STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000360426ENST00000590669STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000360426ENST00000393733STAU1chr20

47790732

-MRPL4chr19

10363073

+
5UTR-3CDSENST00000360426ENST00000588502STAU1chr20

47790732

-MRPL4chr19

10363073

+

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FusionProtFeatures for STAU1_MRPL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAU1

O95793

MRPL4

Q9BYD3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAU1_MRPL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAU1_MRPL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAU1DDX50, HNRNPU, ILF3, NCL, PABPC1, FMR1, DYNC1I1, TUBB3, KIF5A, TUBA1A, RPLP0, RPL6, RPS2, RPS6, RPS3A, RPL7A, RPS8, RPL14, RPL10, RPL15, RPL21, PPP1CA, DHX58, EIF2AK2, CSNK2B, UBE2D3, HDGF, ELAVL1, SIRT7, SPP1, CUL3, CUL1, CAND1, APP, ESR1, MDC1, PAXIP1, PPP1CC, ESR2, CBX8, SRPK3, SRPK1, TARDBP, GTPBP4, UPF1, ZNF622, FZR1, CDC20, IVNS1ABP, TAX1BP3, DHX9, EEF1A1, UPF3B, ABCE1, IGF2BP1, XPO1, ITIH4, HNRNPD, HNRNPM, TUBB, FASN, CLTC, STAU1, HSPA8, ACLY, IARS, COPA, MCM7, LRPPRC, VIM, HSPD1, CAD, HSPA1A, HSPA1B, TCP1, ATP5A1, ETFB, EIF4A1, KHSRP, ATP1A1, EPRS, DARS, RPL13, GNB2L1, PRKDC, PABPC4, SPTAN1, PRPF8, EIF3A, LARS, SNRNP200, LDHA, ENO1, HNRNPC, RPS3, KIF5B, RBMX, QARS, RARS, ACTB, ILF2, DHX15, RPN1, SLC25A5, CDK1, PYGL, LDHB, HNRNPA1, HSPA5, HK1, EEF1D, ATP5C1, RPL4, HSPA9, RPL3, RPL5, RPL8, SLC25A11, CAPRIN1, PTCD3, PHB2, DRG1, DDX3X, EIF3D, SRP72, TPR, PKM, DDX5, RPL7, RPL17, HNRNPA2B1, VARS, YWHAQ, ATP5O, NPEPPS, EIF3B, RPS4X, YBX1, ARF5, RPL19, RPL18, SF3B2, KPNB1, DHX30, DDX1, MOV10, DDX21, PSMD3, SART1, PRPF40A, SF3B1, TOMM70A, OAT, ATP5B, PFKL, HNRNPH1, GARS, RPS9, CCT4, YWHAZ, RPL24, SRSF1, GOLGA3, SMC1A, ZC3H15, GCN1L1, CYFIP2, DOCK7, MYBBP1A, SFXN1, FAM120A, SRP68, IPO5, IRS4, NUDT21, KIF1C, PRKRA, GAPDH, NPM1, FLNA, EEF1G, CANX, RPL9, PHB, DDOST, ARL1, MATR3, NSF, IDH3A, SERPINH1, HSD17B4, HNRNPA3, CSE1L, LYZ, HNRNPK, GOLGA2, HNRNPA0, TRIM28, PCBP1, SAFB, SF3B4, SRSF7, PABPN1, SCFD1, AP3S1, CDC5L, DDX23, COPG2, IGF2BP2, INA, CPSF1, DDX17, AIFM1, SFPQ, HNRNPR, NONO, ARF4, CPSF7, ALDH18A1, RAN, IQGAP1, ACSL3, ALYREF, THOC2, PSMC6, CDIPT, HNRNPH3, SYNCRIP, IGF2BP3, LRRC59, MOGS, NKRF, PTPLAD1, PDHB, SRPRB, DDX39B, SRSF10, PSMD2, RPL29, DHCR7, ARPC4, ARF6, COPZ1, RNF20, HNRNPF, HNRNPH2, KRR1, IPO7, NUP155, PRDX6, FIP1L1, DDX27, SEC61A1, LUC7L2, RAVER1, PLS3, ZFR, AP2M1, AP3D1, CPNE3, ADAR, DNM2, EIF4A3, EIF3E, HSPA1L, HNRNPAB, PTDSS1, RRAGA, RAB10, RAB5C, RAB8A, SRSF4, CCT2, TUBA4A, ATP6V0D1, SPRTN, GLRX3, NXT1, ZMAT3, LONRF1, CUL7, CCDC8, BMI1, HIST1H1A, NOL12, ZBTB38, PRR11, RBM4B, TINCR, NTRK1, IFI16, PCM1, CC2D2A, SCLT1, MCM2, POU5F1, RC3H1, CCNB1, FBXO11, NMNAT1, ELAVL4, RBM34, STAU2, RRP8, CNBP, RALY, MAGEB10, DDX31, KIAA0020, ZNF512, RRS1, RPL37A, WDR46, RPL30, HIST1H1E, RPL26L1, ZC3HAV1, GLYR1, RBM28, RPS14, BAAT, PPAN, RPL18A, PPAN-P2RY11, TARBP2, PLEKHO1, KNOP1, CPNE4, GPATCH4, BRIX1, FTSJ3, DKC1, CYLD, FOXA1, G3BP1, BRCA1MRPL4KRTAP4-12, EIF2B1, ICT1, CUL3, CAND1, MRPL3, MRPL15, MRPL24, MRPL2, MRPL46, MRPL14, MRPL23, MRPL1, TUFM, ILF3, HNRNPR, CYC1, CD55, RPS18, CSNK2A1, C1QBP, SOX2, EXOSC6, XRN2, GRSF1, TRIM23, CLK2, BTRC, FBXW11, MRPL43, MRPL28, HSPD1, YARS2, AMER1, UBR5, MTERF3, NGRN, WDR26, PTCD1, ZSWIM8, MRPL45, FAM83H, TRUB2, MRPL9, ARMC8, MRPL32, MRPL11, DDX28, MRPL48, MRPL40, MAEA, MKLN1, MRPL39, RMND5A, RMND5B, MRPL41, GLS, FASTKD2, RANBP9, RANBP10, CINP, MRPL22, SPATA5L1, MRPL37, PDPR, MRPL10, MRPL49, MRPL44, MRPL50, MRPL38, MRPL20, HTRA2, RPUSD4, GID4, MRPL27, MRPL55, NEFL, MALSU1, MRPL47, MRPL16, MRPS30, GTPBP6, GID8, MRPS18A, MRPL19, TCF25, HNRNPA1, ZMYND19, MSI2, TATDN2, MRPL21, MRPL13, MRPL17, YPEL5, MCAT, MRPL33, GADD45GIP1, MRPL35, POLG, MRPL30, MRPL42, CSNK1E, MRPL51, RNMTL1, MRPL18, AARS2, MRPL53, RPUSD3, MRPL57, MRPL34, MARS2, MRPL52, SAV1, RPL17, RPL8, RPS2, PCNA, L1TD1, ACKR3, DUSP11, GNPNAT1, LONP1, MRPL12, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAU1_MRPL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAU1_MRPL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource