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Fusion gene ID: 36394 |
FusionGeneSummary for STAT5B_CPNE3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STAT5B_CPNE3 | Fusion gene ID: 36394 | Hgene | Tgene | Gene symbol | STAT5B | CPNE3 | Gene ID | 6777 | 8895 |
| Gene name | signal transducer and activator of transcription 5B | copine 3 | |
| Synonyms | STAT5 | CPN3|PRO1071 | |
| Cytomap | 17q21.2 | 8q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal transducer and activator of transcription 5Btranscription factor STAT5B | copine-3copine III | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P51692 | O75131 | |
| Ensembl transtripts involved in fusion gene | ENST00000293328, | ENST00000198765, ENST00000521271, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: STAT5B [Title/Abstract] AND CPNE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STAT5B | GO:0032355 | response to estradiol | 12552091 |
| Hgene | STAT5B | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| Hgene | STAT5B | GO:0045648 | positive regulation of erythrocyte differentiation | 20702587 |
| Hgene | STAT5B | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| Tgene | CPNE3 | GO:0038128 | ERBB2 signaling pathway | 20010870 |
| Tgene | CPNE3 | GO:0071277 | cellular response to calcium ion | 20010870|21087455 |
| Tgene | CPNE3 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE082977 | STAT5B | chr17 | 40351698 | + | CPNE3 | chr8 | 87570548 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000293328 | ENST00000198765 | STAT5B | chr17 | 40351698 | + | CPNE3 | chr8 | 87570548 | - |
| intron-3CDS | ENST00000293328 | ENST00000521271 | STAT5B | chr17 | 40351698 | + | CPNE3 | chr8 | 87570548 | - |
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FusionProtFeatures for STAT5B_CPNE3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STAT5B | CPNE3 |
| Carries out a dual function: signal transduction andactivation of transcription. Mediates cellular responses to thecytokine KITLG/SCF and other growth factors. Binds to the GASelement and activates PRL-induced transcription. Positivelyregulates hematopoietic/erythroid differentiation.{ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:8732682}. | Calcium-dependent phospholipid-binding protein thatplays a role in ERBB2-mediated tumor cell migration in response togrowth factor heregulin stimulation (PubMed:20010870).{ECO:0000269|PubMed:20010870}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STAT5B_CPNE3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STAT5B_CPNE3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STAT5B_CPNE3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | STAT5B | P51692 | DB01254 | Dasatinib | Signal transducer and activator of transcription 5B | small molecule | approved|investigational |
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RelatedDiseases for STAT5B_CPNE3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STAT5B | C1855548 | Laron syndrome type 2 | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | STAT5B | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Hgene | STAT5B | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | STAT5B | C1522378 | Leukemia, Large Granular Lymphocytic | 1 | CTD_human |
| Hgene | STAT5B | C2931322 | T-Lymphocytopenia | 1 | CTD_human |
| Tgene | CPNE3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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