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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36391

FusionGeneSummary for STAT5A_BCL6

check button Fusion gene summary
Fusion gene informationFusion gene name: STAT5A_BCL6
Fusion gene ID: 36391
HgeneTgene
Gene symbol

STAT5A

BCL6

Gene ID

6776

604

Gene namesignal transducer and activator of transcription 5AB cell CLL/lymphoma 6
SynonymsMGF|STAT5BCL5|BCL6A|LAZ3|ZBTB27|ZNF51
Cytomap

17q21.2

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionsignal transducer and activator of transcription 5AB-cell lymphoma 6 proteinB-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB domain-containing protein
Modification date2018052220180527
UniProtAcc

P42229

P41182

Ensembl transtripts involved in fusion geneENST00000345506, ENST00000590949, 
ENST00000546010, ENST00000452307, 
ENST00000588868, ENST00000587646, 
ENST00000406870, ENST00000232014, 
ENST00000450123, ENST00000496823, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 5 X 2=40
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STAT5A [Title/Abstract] AND BCL6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCL6

GO:0000122

negative regulation of transcription by RNA polymerase II

11929873|15577913

TgeneBCL6

GO:0006974

cellular response to DNA damage stimulus

15577913

TgeneBCL6

GO:0030308

negative regulation of cell growth

10490843

TgeneBCL6

GO:0043065

positive regulation of apoptotic process

10490843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ557814STAT5Achr17

40456686

+BCL6chr3

187461805

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000345506ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000345506ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000345506ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000345506ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000590949ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000590949ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000590949ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000590949ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000546010ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000546010ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000546010ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000546010ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000452307ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000452307ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000452307ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000452307ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000588868ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000588868ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000588868ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000588868ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000587646ENST00000406870STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000587646ENST00000232014STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000587646ENST00000450123STAT5Achr17

40456686

+BCL6chr3

187461805

-
intron-intronENST00000587646ENST00000496823STAT5Achr17

40456686

+BCL6chr3

187461805

-

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FusionProtFeatures for STAT5A_BCL6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAT5A

P42229

BCL6

P41182

Carries out a dual function: signal transduction andactivation of transcription. Mediates cellular responses to thecytokine KITLG/SCF and other growth factors. Mediates cellularresponses to ERBB4. May mediate cellular responses to activatedFGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element andactivates PRL-induced transcription. Regulates the expression ofmilk proteins during lactation. {ECO:0000269|PubMed:15534001}. Transcriptional repressor mainly required for germinalcenter (GC) formation and antibody affinity maturation which hasdifferent mechanisms of action specific to the lineage andbiological functions. Forms complexes with different corepressorsand histone deacetylases to repress the transcriptional expressionof different subsets of target genes. Represses its target genesby binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptionalactivity of transcription factors. In GC B-cells, represses genesthat function in differentiation, inflammation, apoptosis and cellcycle control, also autoregulates its transcriptional expressionand up-regulates, indirectly, the expression of some genesimportant for GC reactions, such as AICDA, through the repressionof microRNAs expression, like miR155. An important function is toallow GC B-cells to proliferate very rapidly in response to T-celldependent antigens and tolerate the physiological DNA breaksrequired for immunglobulin class switch recombination and somatichypermutation without inducing a p53/TP53-dependent apoptoticresponse. In follicular helper CD4(+) T-cells (T(FH) cells),promotes the expression of T(FH)-related genes but inhibits thedifferentiation of T(H)1, T(H)2 and T(H)17 cells. Also requiredfor the establishment and maintenance of immunological memory forboth T- and B-cells. Suppresses macrophage proliferation throughcompetition with STAT5 for STAT-binding motifs binding on certaintarget genes, such as CCL2 and CCND2. In response to genotoxicstress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controlsneurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets,such as HES5, including the recruitment of the deacetylase SIRT1and resulting in an epigenetic silencing leading to neuronaldifferentiation. {ECO:0000269|PubMed:10981963,ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651,ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082,ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238,ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614,ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289,ECO:0000269|PubMed:9649500}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAT5A_BCL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAT5A_BCL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAT5A_BCL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAT5A_BCL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAT5AC0024667Animal Mammary Neoplasms5CTD_human
HgeneSTAT5AC0024668Mammary Neoplasms, Experimental3CTD_human
HgeneSTAT5AC0001418Adenocarcinoma2CTD_human
HgeneSTAT5AC0007124Noninfiltrating Intraductal Carcinoma1CTD_human
HgeneSTAT5AC0024121Lung Neoplasms1CTD_human
HgeneSTAT5AC0032927Precancerous Conditions1CTD_human
HgeneSTAT5AC0151744Myocardial Ischemia1CTD_human
HgeneSTAT5AC0206692Carcinoma, Lobular1CTD_human
HgeneSTAT5AC1176475Ductal Carcinoma1CTD_human
HgeneSTAT5AC1458155Mammary Neoplasms1CTD_human
TgeneBCL6C0024305Lymphoma, Non-Hodgkin1CTD_human
TgeneBCL6C0079772T-Cell Lymphoma1CTD_human