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Fusion gene ID: 3639 |
FusionGeneSummary for AVEN_SCG5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AVEN_SCG5 | Fusion gene ID: 3639 | Hgene | Tgene | Gene symbol | AVEN | SCG5 | Gene ID | 57099 | 6447 |
| Gene name | apoptosis and caspase activation inhibitor | secretogranin V | |
| Synonyms | PDCD12 | 7B2|P7B2|SGNE1|SgV | |
| Cytomap | 15q14 | 15q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell death regulator Avenapoptosis, caspase activation inhibitorprogrammed cell death 12 | neuroendocrine protein 7B2pituitary polypeptideprohormone convertase chaperonesecretogranin-5secretory granule endocrine protein Isecretory granule, neuroendocrine protein 1 (7B2 protein) | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NQS1 | P05408 | |
| Ensembl transtripts involved in fusion gene | ENST00000306730, ENST00000558136, | ENST00000413748, ENST00000300175, ENST00000494364, ENST00000497208, ENST00000498069, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 1 X 3=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AVEN [Title/Abstract] AND SCG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AVEN | GO:0043066 | negative regulation of apoptotic process | 10949025 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A2QM-01A | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306730 | ENST00000413748 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| In-frame | ENST00000306730 | ENST00000300175 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| In-frame | ENST00000306730 | ENST00000494364 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| In-frame | ENST00000306730 | ENST00000497208 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| 5CDS-3UTR | ENST00000306730 | ENST00000498069 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| intron-3CDS | ENST00000558136 | ENST00000413748 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| intron-3CDS | ENST00000558136 | ENST00000300175 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| intron-3CDS | ENST00000558136 | ENST00000494364 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| intron-3CDS | ENST00000558136 | ENST00000497208 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
| intron-3UTR | ENST00000558136 | ENST00000498069 | AVEN | chr15 | 34295233 | - | SCG5 | chr15 | 32971967 | + |
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FusionProtFeatures for AVEN_SCG5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AVEN | SCG5 |
| Protects against apoptosis mediated by Apaf-1. | Acts as a molecular chaperone for PCSK2/PC2, preventingits premature activation in the regulated secretory pathway. Bindsto inactive PCSK2 in the endoplasmic reticulum and facilitates itstransport from there to later compartments of the secretorypathway where it is proteolytically matured and activated. Alsorequired for cleavage of PCSK2 but does not appear to be involvedin its folding. Plays a role in regulating pituitary hormonesecretion. The C-terminal peptide inhibits PCSK2 in vitro.{ECO:0000269|PubMed:7913882}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AVEN | chr15:34295233 | chr15:32971967 | ENST00000306730 | - | 2 | 6 | 5_85 | 148 | 363 | Compositional bias | Note=Ala/Gly-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AVEN_SCG5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000413748_chr15_32971967_+_285aa MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF SEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAK >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000300175_chr15_32971967_+_286aa MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF SEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVA >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000494364_chr15_32971967_+_267aa MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000497208_chr15_32971967_+_268aa MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPV EDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000413748_chr15_32971967_+_855nt ATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCGCGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGA GCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGGAGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGC GGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCGGGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTT GAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGGAAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGA TATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAGGGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGA GCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTT AGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAAAACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCA GAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTT TACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAG >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000300175_chr15_32971967_+_858nt ATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCGCGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGA GCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGGAGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGC GGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCGGGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTT GAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGGAAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGA TATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAGGGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGA GCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTT AGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAAAACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACT GCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTC CTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCA >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000494364_chr15_32971967_+_801nt ATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCGCGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGA GCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGGAGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGC GGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCGGGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTT GAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGGAAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGA TATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAGGGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGA GCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTT AGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAAAACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCA GAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATAT >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000497208_chr15_32971967_+_804nt ATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCGCGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGA GCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGGAGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGC GGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCGGGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTT GAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGGAAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGA TATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAGGGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGA GCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACATCGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTT AGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAAAACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACT GCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000413748_chr15_32971967_+_1474nt GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA AACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACA TGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAATCC ATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGA AGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTT TCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAA TAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAACAATAAAAAGCAAGA CTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTGTCATTTGATTTT GATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGACACATTTCACTTGGC >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000300175_chr15_32971967_+_1477nt GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA AACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGA ACATGACTATCCAGGCTTGGGCAAGTGGAACAAGAAACTCCTTTACGAGAAGATGAAGGGAGGAGAGAGACGAAAGCGGAGGAGTGTCAA TCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAG AGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGCACGTGTAAATGGAGTCCCTGTGAATGACAGCAT GTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTCTTCACACCGATGATTCTGCTTTTTGCTAAATTA GAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAAAAATTAAAATGTGAATGTCAACAATAAAAAGCA AGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTATTTTGGCCAAGTCTGTAGAAAGCTGTCATTTGAT TTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCTGTACTCAAGAGGAGGAGCTGACACATTTCACTT >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000494364_chr15_32971967_+_1410nt GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA AACAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGAACA TGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCCCCA TTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATGTGC ACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATTGTC TTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCATAA AAATTAAAATGTGAATGTCAACAATAAAAAGCAAGACTATGAAAGGCTCAGATTTCTTGCAGTTTAAAATGGTGTCTGAGGTTGTACTAT TTTGGCCAAGTCTGTAGAAAGCTGTCATTTGATTTTGATTATGTAGTTCATCCAGCCCTTGGGCATTGTTATACACCAGTAAAGAAGGCT >In-frame_AVEN_ENST00000306730_chr15_34295233_-_SCG5_ENST00000497208_chr15_32971967_+_1214nt GCACCCCGCGCCTCGCTGCTACCGGGCGCCTTTCGCTCGCGGCTCCTCCGTGCGGCCCGCTTCCGGTGGGGCCAGGGCGTCTCCGCCGCA GCTCGGCTCCCGCGCGCTCAGCACCGCCAGCGGCGGCCAGATGCAGGCGGAGCGAGGAGCTCGGGGAGGCCGTGGGCGGCGGCCAGGCCG CGGCCGGCCTGGCGGAGATCGCCACAGCGAGCGGCCCGGAGCCGCAGCGGCGGTAGCCAGAGGCGGCGGCGGAGGCGGCGGCGGGGACGG AGGCGGACGCCGGGGCCGTGGCCGTGGCCGGGGCTTCCGCGGCGCTCGCGGAGGCCGAGGAGGAGGAGGCGCCCCGCGAGGCAGCCGCCG GGAGCCGGGAGGCTGGGGCGCAGGGGCCAGCGCGCCGGTTGAAGATGACAGCGATGCAGAGACCTATGGAGAAGAGAATGATGAACAGGG AAATTATTCTAAAAGAAAGATTGTCTCTAACTGGGATCGATATCAAGATATTGAAAAAGAGGTCAATAATGAAAGTGGAGAGTCACAGAG GGGAACAGATTTCAGTGTCCTCCTTAGCTCTGCAGGTGGAGCTCATGAAGGACTTCAGCATTTGGGTCCTTTTGGCAACATCCCCAACAT CGTGGCAGAGTTGACTGGAGACAACATTCCTAAGGACTTTAGTGAGGATCAGGGGTACCCAGACCCTCCAAATCCCTGTCCTGTTGGAAA AACAGCAGATGATGGATGTCTAGAAAACACCCCTGACACTGCAGAGTTCAGTCGAGAGTTCCAGTTGCACCAGCATCTCTTTGATCCGGA ACATGACTATCCAGGCTTGGGCAAGTGGAGTGTCAATCCATATCTACAAGGACAGAGACTGGATAATGTTGTTGCAAAGAAGTCTGTCCC CCATTTTTCAGATGAGGATAAGGATCCAGAGTAAAGAGAAGATGCTAGACGAAAACCCACATTACCTGTTAGGCCTCAGCATGGCTTATG TGCACGTGTAAATGGAGTCCCTGTGAATGACAGCATGTTTCTTACATAGATAATTATGGATACAAAGCAGCTGTATGTAGATAGTGTATT GTCTTCACACCGATGATTCTGCTTTTTGCTAAATTAGAATAAGAGCTTTTTTGTTTCTTGGGTTTTTAAAATGTGAATCTGCAATGATCA |
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FusionGenePPI for AVEN_SCG5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AVEN | BCL2L1, BCL2, APAF1, MOV10, NXF1, XPO1, HNRNPU, RPL10 | SCG5 | UBQLN4, NR1H2, KHDRBS1, UBQLN1, CSH2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AVEN_SCG5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AVEN_SCG5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AVEN | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | SCG5 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | SCG5 | C0025149 | Medulloblastoma | 1 | CTD_human |
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