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Fusion gene ID: 36387 |
FusionGeneSummary for STAT3_TPM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STAT3_TPM3 | Fusion gene ID: 36387 | Hgene | Tgene | Gene symbol | STAT3 | TPM3 | Gene ID | 6774 | 7170 |
| Gene name | signal transducer and activator of transcription 3 | tropomyosin 3 | |
| Synonyms | ADMIO|ADMIO1|APRF|HIES | CAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30 | |
| Cytomap | 17q21.2 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor | tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P40763 | P06753 | |
| Ensembl transtripts involved in fusion gene | ENST00000264657, ENST00000585517, ENST00000389272, ENST00000588969, ENST00000404395, ENST00000590776, | ENST00000368533, ENST00000469717, ENST00000330188, ENST00000341485, ENST00000341372, ENST00000328159, ENST00000271850, ENST00000302206, ENST00000368531, ENST00000323144, ENST00000368530, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 7 X 6 X 4=168 |
| # samples | 8 | 9 | |
| ** MAII score | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: STAT3 [Title/Abstract] AND TPM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STAT3 | GO:0006355 | regulation of transcription, DNA-templated | 15664994|17344214 |
| Hgene | STAT3 | GO:0006606 | protein import into nucleus | 18234692 |
| Hgene | STAT3 | GO:0010628 | positive regulation of gene expression | 23820254 |
| Hgene | STAT3 | GO:0030522 | intracellular receptor signaling pathway | 17324931 |
| Hgene | STAT3 | GO:0032355 | response to estradiol | 12552091 |
| Hgene | STAT3 | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| Hgene | STAT3 | GO:0033210 | leptin-mediated signaling pathway | 17344214 |
| Hgene | STAT3 | GO:0035278 | miRNA mediated inhibition of translation | 23820254 |
| Hgene | STAT3 | GO:0044320 | cellular response to leptin stimulus | 17344214 |
| Hgene | STAT3 | GO:0044321 | response to leptin | 17344214 |
| Hgene | STAT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19390056 |
| Hgene | STAT3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17324931 |
| Hgene | STAT3 | GO:0051726 | regulation of cell cycle | 17344214 |
| Hgene | STAT3 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| Hgene | STAT3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| Hgene | STAT3 | GO:0070102 | interleukin-6-mediated signaling pathway | 12359225|12552091|17324931 |
| Hgene | STAT3 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19390056|23820254 |
| Hgene | STAT3 | GO:2000637 | positive regulation of gene silencing by miRNA | 23820254 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-G3-A7M7-01A | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000264657 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000264657 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000264657 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000264657 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000264657 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000264657 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| Frame-shift | ENST00000585517 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000585517 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000585517 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000585517 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000585517 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000585517 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| Frame-shift | ENST00000389272 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000389272 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000389272 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000389272 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000389272 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000389272 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| Frame-shift | ENST00000588969 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000588969 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000588969 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000588969 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000588969 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000588969 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| Frame-shift | ENST00000404395 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-intron | ENST00000404395 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000404395 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000404395 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000404395 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| 5CDS-5UTR | ENST00000404395 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-3CDS | ENST00000590776 | ENST00000368533 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000469717 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000330188 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000341485 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000341372 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000328159 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-intron | ENST00000590776 | ENST00000271850 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-5UTR | ENST00000590776 | ENST00000302206 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-5UTR | ENST00000590776 | ENST00000368531 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-5UTR | ENST00000590776 | ENST00000323144 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
| intron-5UTR | ENST00000590776 | ENST00000368530 | STAT3 | chr17 | 40497577 | - | TPM3 | chr1 | 154148724 | - |
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FusionProtFeatures for STAT3_TPM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STAT3 | TPM3 |
| Signal transducer and transcription activator thatmediates cellular responses to interleukins, KITLG/SCF, LEP andother growth factors (PubMed:10688651, PubMed:12359225,PubMed:12873986, PubMed:15194700, PubMed:17344214,PubMed:18242580, PubMed:23084476). Once activated, recruitscoactivators, such as NCOA1 or MED1, to the promoter region of thetarget gene (PubMed:17344214). May mediate cellular responses toactivated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Bindsto the interleukin-6 (IL-6)-responsive elements identified in thepromoters of various acute-phase protein genes (PubMed:12359225).Activated by IL31 through IL31RA (PubMed:15194700). Acts as aregulator of inflammatory response by regulating differentiationof naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells(Treg): deacetylation and oxidation of lysine residues by LOXL3,leads to disrupt STAT3 dimerization and inhibit its transcriptionactivity (PubMed:28065600). Involved in cell cycle regulation byinducing the expression of key genes for the progression from G1to S phase, such as CCND1 (PubMed:17344214). Mediates the effectsof LEP on melanocortin production, body energy homeostasis andlactation (By similarity). May play an apoptotic role bytransctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy byinhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucialrole in basal beta cell functions, such as regulation of insulinsecretion (By similarity). {ECO:0000250|UniProtKB:P42227,ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225,ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700,ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580,ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for STAT3_TPM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for STAT3_TPM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| STAT3 | RPA2, RET, EGFR, EPHA5, JAK1, TRIP10, AR, NR3C1, MYOD1, NDUFA13, KAT5, CREBBP, EP300, SMAD1, STAT1, PTPN11, IL1RAP, IL2RB, FES, NCOA1, ESR1, PIAS3, PTPN2, CCND1, HSP90AA1, KHDRBS1, ERBB2, MTOR, ELP2, PML, PTK2, JUN, IFNAR1, TSHR, HNF1A, IL6ST, PDIA3, NFKB1, RELA, IL6R, NMI, EIF2AK2, RAC1, SRC, BMX, GTF2I, CDKN1A, GHR, CCR5, JAK2, HIF1A, MET, CTR9, ALK, HOXC11, STAT6, SS18L1, PCBD2, SP1, BCL3, PELP1, DNMT1, HDAC1, RB1, HDAC2, HDAC3, STAT3, NFKBIZ, CEBPB, SMARCA4, CDK9, FGFR1, FGFR2, PPP2R1B, TIRAP, PRKCD, MAPK8, PGR, SIRT1, SETD7, KDM1A, RUNX2, ELAVL1, BHLHE40, CD44, DAXX, SOCS7, IRAK1, MAP3K7, MAPK1, FHL2, TRAF6, ZFHX3, APEX1, PTPN1, JAK3, TRIM28, HCK, LYN, FYN, FGR, HES1, HES5, SIN3A, BICD1, ECH1, SRI, SULT2A1, MRPS31, BCKDK, CORO1A, GNL3, OGDHL, NR4A1, CAPN1, MORC4, RPS9, HIVEP1, ASXL1, RPL11, NIF3L1, SUPT20H, HLA-A, AMBP, CAPNS1, LAMB2, HNRNPM, SIAH1, SIAH2, SCAF11, MAP3K13, SPRY1, SSSCA1, ZFPM2, ARFIP2, SRRT, ERBB2IP, IL22RA1, CEP120, LUC7L2, PSMG3, ARFIP1, IVNS1ABP, MSH2, PUS7, TBC1D15, TBCD, BRD4, ADRB2, COPS5, HIC1, USP22, GNB2, GADD45A, BLK, LMO2, SYK, SHMT2, MOV10, NXF1, NFKB2, AZU1, CACNG2, NXPH2, DDX19B, RP2, TRPV5, TCEAL1, IDE, NTRK1, BRWD1, FAM208B, CCDC87, DOK2, DOK3, FAM117B, GSTCD, HESX1, KRTAP10-7, MAPKAPK2, MPZL1, NUFIP2, PAQR7, PIK3R3, RABGAP1, SH2D2A, TM4SF19, TWIST1, VPS39, WDFY3, ZNF281, ZNF829, ABL2, CA8, CBL, DTNA, LASP1, LCK, PIK3R1, PIK3R2, PPARD, SH3BP2, BATF3, CHTF18, CNDP2, KLF15, NACAD, NXT2, OFCC1, PINK1, TDG, ZNF557, ATF3, MNDA, PAFAH1B2, IGF1R, PDGFRA, PDGFRB, STAT5B, ANKRD26P1, KIF27, PLA2G4A, LRRFIP2, HSP90B1, RRAD, FBXW7, STMN1, MAGEC2, RFWD2, CREB1, RELB, CDK15, LRRC32, IL20RA, TBC1D22B, TMEM206, MBLAC2, VASN, C3AR1, PVR, DLK2, ANXA2, TRIM25, TES | TPM3 | KXD1, TFPT, MCC, EIF4A2, TPM3, TP73, NEK2, RAD21, ELAVL1, SP1, CUL3, CDK2, LRRK2, TPM4, SEC23IP, KYNU, TPM2, TPM1, PRDX1, THOC1, CDC123, SF3A2, SEPT9, HSPB1, BRCA1, MDC1, PAXIP1, HSP90AA1, HSP90AB1, FN1, PAN2, HDAC8, FBXO5, TRAP1, PARK2, FASN, FKBP4, FKBP5, MAGED2, CAP1, MCM3, MGEA5, TP53, HSF2, IFIT3, KCNE1, KIFC3, MAGEA11, PBX3, TRIM27, VPS52, TNNT1, TRIP6, MAD1L1, TLK1, OIP5, BLOC1S6, CCHCR1, THAP1, CCDC146, CCDC102B, CCDC114, SYCE1, IKBIP, C1orf216, LCA5L, FAM9C, HDDC3, WASH3P, LURAP1, SHMT2, MOV10, NXF1, CUL7, OBSL1, RNF2, EGFR, DAPK1, ACTN2, AHCYL1, ATP1A1, CKB, CKMT1B, CKMT1A, COX5A, CYC1, OSTF1, ACTN1, ACTN4, ATP5F1, COX4I1, MTCH1, MYH7B, NDUFB10, PSMA2, PSMA6, STMN1, TBCD, UQCRC2, NTRK1, DVL2, HOOK2, ADD1, CAPZA2, MYH9, PPP1CB, PPP1CC, IQGAP1, PDLIM7, ANLN, MYO5C, MYO19, MYO18A, MCM2, RNF20, IMP3, CALCOCO1, JUN, METTL2B, CCDC101, SPAG9, PARK7, PDHA1, VDAC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for STAT3_TPM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAT3_TPM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | STAT3 | C3489795 | Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant | 4 | CTD_human;ORPHANET;UNIPROT |
| Hgene | STAT3 | C0018800 | Cardiomegaly | 3 | CTD_human |
| Hgene | STAT3 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Hgene | STAT3 | C0001418 | Adenocarcinoma | 2 | CTD_human |
| Hgene | STAT3 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
| Hgene | STAT3 | C0009324 | Ulcerative Colitis | 2 | CTD_human |
| Hgene | STAT3 | C0021368 | Inflammation | 2 | CTD_human |
| Hgene | STAT3 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Hgene | STAT3 | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
| Hgene | STAT3 | C0878544 | Cardiomyopathies | 2 | CTD_human |
| Hgene | STAT3 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | STAT3 | C0004364 | Autoimmune Diseases | 1 | CTD_human;HPO |
| Hgene | STAT3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | STAT3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | STAT3 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | STAT3 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | STAT3 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | STAT3 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Hgene | STAT3 | C0015967 | Fever | 1 | CTD_human |
| Hgene | STAT3 | C0016059 | Fibrosis | 1 | CTD_human |
| Hgene | STAT3 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| Hgene | STAT3 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | STAT3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0023492 | Leukemia, T-Cell | 1 | CTD_human |
| Hgene | STAT3 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Hgene | STAT3 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| Hgene | STAT3 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | STAT3 | C0025149 | Medulloblastoma | 1 | CTD_human |
| Hgene | STAT3 | C0025261 | Memory Disorders | 1 | CTD_human |
| Hgene | STAT3 | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | STAT3 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | STAT3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | CTD_human |
| Hgene | STAT3 | C0235833 | Congenital diaphragmatic hernia | 1 | CTD_human |
| Hgene | STAT3 | C0333641 | Atrophic | 1 | CTD_human |
| Hgene | STAT3 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Hgene | STAT3 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | STAT3 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Hgene | STAT3 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Hgene | STAT3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | STAT3 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
| Hgene | STAT3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | STAT3 | C3887645 | Job Syndrome | 1 | CTD_human |
| Hgene | STAT3 | C4014795 | AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET | 1 | ORPHANET;UNIPROT |
| Tgene | TPM3 | C1836448 | Nemaline myopathy 1 | 9 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TPM3 | C0546264 | Congenital Fiber Type Disproportion | 5 | ORPHANET;UNIPROT |
| Tgene | TPM3 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | TPM3 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Tgene | TPM3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | TPM3 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | TPM3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | TPM3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | TPM3 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
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