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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36374

FusionGeneSummary for STAT1_PPP3R1

check button Fusion gene summary
Fusion gene informationFusion gene name: STAT1_PPP3R1
Fusion gene ID: 36374
HgeneTgene
Gene symbol

STAT1

PPP3R1

Gene ID

6772

5534

Gene namesignal transducer and activator of transcription 1protein phosphatase 3 regulatory subunit B, alpha
SynonymsCANDF7|IMD31A|IMD31B|IMD31C|ISGF-3|STAT91CALNB1|CNB|CNB1
Cytomap

2q32.2

2p14

Type of geneprotein-codingprotein-coding
Descriptionsignal transducer and activator of transcription 1-alpha/betasignal transducer and activator of transcription 1, 91kDsignal transducer and activator of transcription 1, 91kDatranscription factor ISGF-3 components p91/p84calcineurin subunit B type 1calcineurin B, type I (19kDa)protein phosphatase 2B regulatory subunit 1protein phosphatase 2B regulatory subunit B alphaprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I
Modification date2018052720180522
UniProtAcc

P42224

P63098

Ensembl transtripts involved in fusion geneENST00000361099, ENST00000409465, 
ENST00000540176, ENST00000392322, 
ENST00000392323, 
ENST00000234310, 
ENST00000409752, ENST00000409377, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STAT1 [Title/Abstract] AND PPP3R1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTAT1

GO:0007259

JAK-STAT cascade

22002246

HgeneSTAT1

GO:0010742

macrophage derived foam cell differentiation

26504087

HgeneSTAT1

GO:0032727

positive regulation of interferon-alpha production

28753426

HgeneSTAT1

GO:0033209

tumor necrosis factor-mediated signaling pathway

10848577

HgeneSTAT1

GO:0045893

positive regulation of transcription, DNA-templated

10973496

HgeneSTAT1

GO:0051607

defense response to virus

28753426

HgeneSTAT1

GO:0060333

interferon-gamma-mediated signaling pathway

21268089

HgeneSTAT1

GO:0060337

type I interferon signaling pathway

23386060

HgeneSTAT1

GO:0071346

cellular response to interferon-gamma

23386060

TgenePPP3R1

GO:0033173

calcineurin-NFAT signaling cascade

22688515

TgenePPP3R1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF379791STAT1chr2

191866819

+PPP3R1chr2

68432111

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361099ENST00000234310STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000361099ENST00000409752STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000361099ENST00000409377STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000409465ENST00000234310STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000409465ENST00000409752STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000409465ENST00000409377STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000540176ENST00000234310STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000540176ENST00000409752STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000540176ENST00000409377STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392322ENST00000234310STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392322ENST00000409752STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392322ENST00000409377STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392323ENST00000234310STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392323ENST00000409752STAT1chr2

191866819

+PPP3R1chr2

68432111

+
intron-intronENST00000392323ENST00000409377STAT1chr2

191866819

+PPP3R1chr2

68432111

+

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FusionProtFeatures for STAT1_PPP3R1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAT1

P42224

PPP3R1

P63098

Regulatory subunit of calcineurin, a calcium-dependent,calmodulin stimulated protein phosphatase. Confers calciumsensitivity. {ECO:0000269|PubMed:26794871}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAT1_PPP3R1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAT1_PPP3R1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAT1_PPP3R1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAT1_PPP3R1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTAT1C3279990CANDIDIASIS, FAMILIAL, 75ORPHANET;UNIPROT
HgeneSTAT1C3151088IMMUNODEFICIENCY 31B3ORPHANET;UNIPROT
HgeneSTAT1C4013950IMMUNODEFICIENCY 31A3ORPHANET;UNIPROT
HgeneSTAT1C0003873Rheumatoid Arthritis1CTD_human
HgeneSTAT1C0006845Candidiasis, Chronic Mucocutaneous1CTD_human;HPO
HgeneSTAT1C0010823Cytomegalovirus Infections1CTD_human
HgeneSTAT1C0021400Influenza1CTD_human
HgeneSTAT1C0023890Liver Cirrhosis1CTD_human
HgeneSTAT1C0026918Mycobacterium Infections1CTD_human
HgeneSTAT1C0993582Arthritis, Experimental1CTD_human
HgeneSTAT1C1384666hearing impairment1CTD_human
HgeneSTAT1C2239176Liver carcinoma1CTD_human
TgenePPP3R1C0036341Schizophrenia1PSYGENET
TgenePPP3R1C0149721Left Ventricular Hypertrophy1CTD_human
TgenePPP3R1C0151744Myocardial Ischemia1CTD_human