FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36360

FusionGeneSummary for STARD3_STXBP4

check button Fusion gene summary
Fusion gene informationFusion gene name: STARD3_STXBP4
Fusion gene ID: 36360
HgeneTgene
Gene symbol

STARD3

STXBP4

Gene ID

10948

252983

Gene nameStAR related lipid transfer domain containing 3syntaxin binding protein 4
SynonymsCAB1|MLN64|es64Synip
Cytomap

17q12

17q22

Type of geneprotein-codingprotein-coding
DescriptionstAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein relatedsyntaxin-binding protein 4STX4-interacting proteinsyntaxin 4 interacting protein
Modification date2018052220180520
UniProtAcc

Q14849

Q6ZWJ1

Ensembl transtripts involved in fusion geneENST00000336308, ENST00000578232, 
ENST00000544210, ENST00000394250, 
ENST00000580611, 
ENST00000299341, 
ENST00000376352, ENST00000405898, 
ENST00000434978, ENST00000398391, 
Fusion gene scores* DoF score21 X 6 X 7=8828 X 5 X 5=200
# samples 227
** MAII scorelog2(22/882*10)=-2.00327513203286
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/200*10)=-1.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STARD3 [Title/Abstract] AND STXBP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTARD3

GO:0030301

cholesterol transport

28377464

HgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464

TgeneSTXBP4

GO:0006974

cellular response to DNA damage stimulus

19451233

TgeneSTXBP4

GO:0061178

regulation of insulin secretion involved in cellular response to glucose stimulus

12855681


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-3C-AALI-01ASTARD3chr17

37818597

+STXBP4chr17

53150261

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336308ENST00000299341STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000336308ENST00000376352STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000336308ENST00000405898STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000336308ENST00000434978STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000336308ENST00000398391STARD3chr17

37818597

+STXBP4chr17

53150261

+
intron-intronENST00000578232ENST00000299341STARD3chr17

37818597

+STXBP4chr17

53150261

+
intron-intronENST00000578232ENST00000376352STARD3chr17

37818597

+STXBP4chr17

53150261

+
intron-intronENST00000578232ENST00000405898STARD3chr17

37818597

+STXBP4chr17

53150261

+
intron-intronENST00000578232ENST00000434978STARD3chr17

37818597

+STXBP4chr17

53150261

+
intron-intronENST00000578232ENST00000398391STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000544210ENST00000299341STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000544210ENST00000376352STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000544210ENST00000405898STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000544210ENST00000434978STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000544210ENST00000398391STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000394250ENST00000299341STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000394250ENST00000376352STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000394250ENST00000405898STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000394250ENST00000434978STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000394250ENST00000398391STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000580611ENST00000299341STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000580611ENST00000376352STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000580611ENST00000405898STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000580611ENST00000434978STARD3chr17

37818597

+STXBP4chr17

53150261

+
5CDS-intronENST00000580611ENST00000398391STARD3chr17

37818597

+STXBP4chr17

53150261

+

Top

FusionProtFeatures for STARD3_STXBP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STARD3

Q14849

STXBP4

Q6ZWJ1

Sterol-binding protein that mediates cholesteroltransport from the endoplasmic reticulum to endosomes(PubMed:11053434, PubMed:15930133, PubMed:22514632,PubMed:28377464). Creates contact site between the endoplasmicreticulum and late endosomes: localizes to late endosome membranesand contacts the endoplasmic reticulum via interaction with VAPAand VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipidtransfer protein that redirects sterol to the endosome at theexpense of the cell membrane and favors membrane formation insideendosomes (PubMed:28377464). May also mediate cholesteroltransport between other membranes, such as mitochondria membraneor cell membrane (PubMed:12070139, PubMed:19965586). However, suchresults need additional experimental evidences; probably mainlymediates cholesterol transport from the endoplasmic reticulum toendosomes (PubMed:28377464). Does not activate transcriptionalcholesterol sensing (PubMed:28377464). Able to bind other lipids,such as lutein, a xanthophyll carotenoids that form the macularpigment of the retina (PubMed:21322544).{ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:12070139,ECO:0000269|PubMed:15930133, ECO:0000269|PubMed:19965586,ECO:0000269|PubMed:21322544, ECO:0000269|PubMed:22514632,ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}. Plays a role in the translocation of transport vesiclesfrom the cytoplasm to the plasma membrane. Inhibits thetranslocation of SLC2A4 from intracellular vesicles to the plasmamembrane by STX4A binding and preventing the interaction betweenSTX4A and VAMP2. Stimulation with insulin disrupts the interactionwith STX4A, leading to increased levels of SLC2A4 at the plasmamembrane. May also play a role in the regulation of insulinrelease by pancreatic beta cells after stimulation by glucose (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STARD3_STXBP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STARD3_STXBP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STARD3GOPC, SPACA1, SDF4, ERGIC3, HEPACAM2, VAPB, CREB3, C19orf26, MME, P2RX2, SLC15A1, CHRM3, MANSC1, PMEL, CLEC2D, TSPYL6, TRIM25, LMNASTXBP4ATN1, LATS2, KLHL42, PRRG4, TMEM171, C20orf195, SUSD6, MBIP, FAM189A2, VPS28, LDLRAD4, TP53, OFD1, CNTROB, CEP128, PTPN13, ERP44, PTPN14, WDTC1, CDR2, ARRDC3, RGS2, CCDC120, PLK1, PMF1, MPP5, PTPN21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STARD3_STXBP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STARD3_STXBP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSTARD3C0033578Prostatic Neoplasms2CTD_human
HgeneSTARD3C3496069cocaine use1PSYGENET