FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36330

FusionGeneSummary for STAM_PTPLA

check button Fusion gene summary
Fusion gene informationFusion gene name: STAM_PTPLA
Fusion gene ID: 36330
HgeneTgene
Gene symbol

STAM

PTPLA

Gene ID

8027

9200

Gene namesignal transducing adaptor molecule3-hydroxyacyl-CoA dehydratase 1
SynonymsSTAM-1|STAM1CAP|PTPLA
Cytomap

10p12.33

10p12.33

Type of geneprotein-codingprotein-coding
Descriptionsignal transducing adapter molecule 1HSE1 homologsignal transducing adaptor molecule (SH3 domain and ITAM motif) 1very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1cementum attachment proteinprotein tyrosine phosphatase-like (proline instead of catalytic arginine), member Avery-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
Modification date2018052220180523
UniProtAcc

Q92783

Ensembl transtripts involved in fusion geneENST00000377524, ENST00000540523, 
ENST00000361271, ENST00000326961, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 1 X 2=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: STAM [Title/Abstract] AND PTPLA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1ES-06ASTAMchr10

17702547

+PTPLAchr10

17646046

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377524ENST00000361271STAMchr10

17702547

+PTPLAchr10

17646046

-
5CDS-intronENST00000377524ENST00000326961STAMchr10

17702547

+PTPLAchr10

17646046

-
5UTR-3CDSENST00000540523ENST00000361271STAMchr10

17702547

+PTPLAchr10

17646046

-
5UTR-intronENST00000540523ENST00000326961STAMchr10

17702547

+PTPLAchr10

17646046

-

Top

FusionProtFeatures for STAM_PTPLA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAM

Q92783

PTPLA

Involved in intracellular signal transduction mediatedby cytokines and growth factors. Upon IL-2 and GM-CSL stimulation,it plays a role in signaling leading to DNA synthesis and MYCinduction. May also play a role in T-cell development. Involved indown-regulation of receptor tyrosine kinase via multivesicularbody (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0complex binds ubiquitin and acts as sorting machinery thatrecognizes ubiquitinated receptors and transfers them to furthersequential lysosomal sorting/trafficking processes. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07132_14185289Topological domainCytoplasmic
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07160_16585289Topological domainLumenal
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07181_20385289Topological domainCytoplasmic
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07222_25185289Topological domainLumenal
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07270_28885289Topological domainCytoplasmic
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-0796_11485289Topological domainLumenal
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07115_13185289TransmembraneHelical
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07142_15985289TransmembraneHelical
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07166_18085289TransmembraneHelical
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07204_22185289TransmembraneHelical
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-07252_26985289TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAMchr10:17702547chr10:17646046ENST00000377524+21416_14341541DomainVHS
HgeneSTAMchr10:17702547chr10:17646046ENST00000377524+214171_19041541DomainUIM
HgeneSTAMchr10:17702547chr10:17646046ENST00000377524+214210_26941541DomainSH3
HgeneSTAMchr10:17702547chr10:17646046ENST00000377524+214370_38741541DomainNote=ITAM
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-071_7585289Topological domainCytoplasmic
TgenePTPLAchr10:17702547chr10:17646046ENST00000361271-0776_9585289TransmembraneHelical


Top

FusionGeneSequence for STAM_PTPLA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STAM_PTPLA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAMTIMM8A, HGS, STAMBP, USP8, JAK2, JAK3, UBC, CLTC, ARRB1, CXCR4, CD79B, ITCH, SEC31A, STAM2, SORT1, RFFL, PJA1, TRIM63, TRIM55, TRIM54, USP15, USP28, PRDX5, AHCYL1, ZRANB2, IGBP1, SSSCA1, USP34, S100A11, SERPINH1, PIR, UBQLN4, CPLX1, STMN2, SULT1A1, STUB1, TBCK, THADA, ZPR1, UBQLN2, TPM2, PPM1G, UNK, PPP1CC, MED28, PPP1CA, SNTA1, YWHAB, UBE4B, DTX3L, MAP3K1, GGA1, TLE3, NTRK1, FBF1, TMEM17, TMEM216, PTPN23, ARRDC3, PMEPA1, PTPRN2, TPTE, TRAF7, NCEH1, SNX1PTPLASEMG2, SEMG1, SLC15A1, EDEM2, UBC, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STAM_PTPLA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STAM_PTPLA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource