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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36328

FusionGeneSummary for STAM_EPYC

check button Fusion gene summary
Fusion gene informationFusion gene name: STAM_EPYC
Fusion gene ID: 36328
HgeneTgene
Gene symbol

STAM

EPYC

Gene ID

8027

1833

Gene namesignal transducing adaptor moleculeepiphycan
SynonymsSTAM-1|STAM1DSPG3|PGLB|Pg-Lb|SLRR3B
Cytomap

10p12.33

12q21.33

Type of geneprotein-codingprotein-coding
Descriptionsignal transducing adapter molecule 1HSE1 homologsignal transducing adaptor molecule (SH3 domain and ITAM motif) 1epiphycandermatan sulfate proteoglycan 3epiphycan proteoglycanproteoglycan-lbsmall chondroitin/dermatan sulfate proteoglycan
Modification date2018052220180519
UniProtAcc

Q92783

Q99645

Ensembl transtripts involved in fusion geneENST00000377524, ENST00000540523, 
ENST00000261172, 
Fusion gene scores* DoF score3 X 2 X 3=188 X 4 X 4=128
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/128*10)=-0.870716983055034
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAM [Title/Abstract] AND EPYC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1L4-01ASTAMchr10

17686378

+EPYCchr12

91372039

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377524ENST00000261172STAMchr10

17686378

+EPYCchr12

91372039

-
5UTR-3CDSENST00000540523ENST00000261172STAMchr10

17686378

+EPYCchr12

91372039

-

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FusionProtFeatures for STAM_EPYC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAM

Q92783

EPYC

Q99645

Involved in intracellular signal transduction mediatedby cytokines and growth factors. Upon IL-2 and GM-CSL stimulation,it plays a role in signaling leading to DNA synthesis and MYCinduction. May also play a role in T-cell development. Involved indown-regulation of receptor tyrosine kinase via multivesicularbody (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0complex binds ubiquitin and acts as sorting machinery thatrecognizes ubiquitinated receptors and transfers them to furthersequential lysosomal sorting/trafficking processes. May have a role in bone formation and also inestablishing the ordered structure of cartilage through matrixorganization.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for STAM_EPYC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for STAM_EPYC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAMTIMM8A, HGS, STAMBP, USP8, JAK2, JAK3, UBC, CLTC, ARRB1, CXCR4, CD79B, ITCH, SEC31A, STAM2, SORT1, RFFL, PJA1, TRIM63, TRIM55, TRIM54, USP15, USP28, PRDX5, AHCYL1, ZRANB2, IGBP1, SSSCA1, USP34, S100A11, SERPINH1, PIR, UBQLN4, CPLX1, STMN2, SULT1A1, STUB1, TBCK, THADA, ZPR1, UBQLN2, TPM2, PPM1G, UNK, PPP1CC, MED28, PPP1CA, SNTA1, YWHAB, UBE4B, DTX3L, MAP3K1, GGA1, TLE3, NTRK1, FBF1, TMEM17, TMEM216, PTPN23, ARRDC3, PMEPA1, PTPRN2, TPTE, TRAF7, NCEH1, SNX1EPYCCRK, PLCG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for STAM_EPYC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STAM_EPYC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource