FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36296

FusionGeneSummary for STAG1_CCDC77

check button Fusion gene summary
Fusion gene informationFusion gene name: STAG1_CCDC77
Fusion gene ID: 36296
HgeneTgene
Gene symbol

STAG1

CCDC77

Gene ID

56937

84318

Gene nameprostate transmembrane protein, androgen induced 1coiled-coil domain containing 77
SynonymsSTAG1|TMEPAI-
Cytomap

20q13.31

12p13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNAcoiled-coil domain-containing protein 77
Modification date2018051920180523
UniProtAcc

Q8WVM7

Q9BR77

Ensembl transtripts involved in fusion geneENST00000383202, ENST00000236698, 
ENST00000434713, ENST00000480733, 
ENST00000536929, 
ENST00000540180, 
ENST00000422000, ENST00000540344, 
ENST00000239830, ENST00000412006, 
Fusion gene scores* DoF score12 X 10 X 9=10803 X 5 X 3=45
# samples 144
** MAII scorelog2(14/1080*10)=-2.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAG1 [Title/Abstract] AND CCDC77 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTAG1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

HgeneSTAG1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

HgeneSTAG1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A129-01ASTAG1chr3

136471037

-CCDC77chr12

514677

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000383202ENST00000540180STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000383202ENST00000422000STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000383202ENST00000540344STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000383202ENST00000239830STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000383202ENST00000412006STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000236698ENST00000540180STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000236698ENST00000422000STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000236698ENST00000540344STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000236698ENST00000239830STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000236698ENST00000412006STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000434713ENST00000540180STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000434713ENST00000422000STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000434713ENST00000540344STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000434713ENST00000239830STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000434713ENST00000412006STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000480733ENST00000540180STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000480733ENST00000422000STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-intronENST00000480733ENST00000540344STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000480733ENST00000239830STAG1chr3

136471037

-CCDC77chr12

514677

+
5UTR-5UTRENST00000480733ENST00000412006STAG1chr3

136471037

-CCDC77chr12

514677

+
intron-intronENST00000536929ENST00000540180STAG1chr3

136471037

-CCDC77chr12

514677

+
intron-5UTRENST00000536929ENST00000422000STAG1chr3

136471037

-CCDC77chr12

514677

+
intron-intronENST00000536929ENST00000540344STAG1chr3

136471037

-CCDC77chr12

514677

+
intron-5UTRENST00000536929ENST00000239830STAG1chr3

136471037

-CCDC77chr12

514677

+
intron-5UTRENST00000536929ENST00000412006STAG1chr3

136471037

-CCDC77chr12

514677

+

Top

FusionProtFeatures for STAG1_CCDC77


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STAG1

Q8WVM7

CCDC77

Q9BR77

Component of cohesin complex, a complex required for thecohesion of sister chromatids after DNA replication. The cohesincomplex apparently forms a large proteinaceous ring within whichsister chromatids can be trapped. At anaphase, the complex iscleaved and dissociates from chromatin, allowing sister chromatidsto segregate. The cohesin complex may also play a role in spindlepole assembly during mitosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for STAG1_CCDC77


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for STAG1_CCDC77


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
STAG1SMC1A, SMC3, RAD21, PDS5A, TP73, PDS5B, WFDC5, WAPAL, CALM1, TERF1, TINF2, HDAC11, EED, CD274, GPR183, PNKD, PTGER3, EXOSC9, SMC1B, KIF20B, CDCA5, FOXL1, USP37, SNW1, SIGLECL1, EPHA1, TRMT13, CD83, TMEM206CCDC77LATS2, LTBR, MED4, CEP290, PCM1, CEP170, KIAA0753, CEP120, SPICE1, CEP128, CEP135, CEP63, CEP89, NINL, ODF2, PRKAR2B, OFD1, DYNLL1, FGFR1OP, MAPRE1, CCDC14, NEDD1, KIF7, PPP2R3C, CDC14A, TPTE2, IKZF5, PRDM5, CCDC136, SYT12, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for STAG1_CCDC77


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for STAG1_CCDC77


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource