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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36287

FusionGeneSummary for ST8SIA1_IFLTD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST8SIA1_IFLTD1
Fusion gene ID: 36287
HgeneTgene
Gene symbol

ST8SIA1

IFLTD1

Gene ID

6489

160492

Gene nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1lamin tail domain containing 1
SynonymsGD3S|SIAT8|SIAT8-A|SIAT8A|ST8SiaIIFLTD1|LMNARS1|PAS1C1
Cytomap

12p12.1

12p12.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-N-acetylneuraminide alpha-2,8-sialyltransferaseST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1alpha-2,8-sialyltransferase 8Adisialoganglioside (GD3) synthaseganglioside GD3 synthaseganglioside GT3 synthaseganglioside-specific alphalamin tail domain-containing protein 1intermediate filament tail domain containing 1intermediate filament tail domain-containing protein 1
Modification date2018051920180519
UniProtAcc

Q92185

Ensembl transtripts involved in fusion geneENST00000396037, ENST00000539510, 
ENST00000536558, ENST00000404299, 
ENST00000381424, 
ENST00000282881, 
ENST00000539744, ENST00000458174, 
ENST00000445693, ENST00000413632, 
Fusion gene scores* DoF score5 X 3 X 5=755 X 3 X 3=45
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ST8SIA1 [Title/Abstract] AND IFLTD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A2LM-01AST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000396037ENST00000282881ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-5UTRENST00000396037ENST00000539744ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-5UTRENST00000396037ENST00000458174ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-intronENST00000396037ENST00000445693ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-intronENST00000396037ENST00000413632ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
In-frameENST00000539510ENST00000282881ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-5UTRENST00000539510ENST00000539744ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-5UTRENST00000539510ENST00000458174ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-intronENST00000539510ENST00000445693ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
5CDS-intronENST00000539510ENST00000413632ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-3CDSENST00000536558ENST00000282881ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000536558ENST00000539744ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000536558ENST00000458174ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000536558ENST00000445693ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000536558ENST00000413632ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-3CDSENST00000404299ENST00000282881ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000404299ENST00000539744ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000404299ENST00000458174ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000404299ENST00000445693ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000404299ENST00000413632ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-3CDSENST00000381424ENST00000282881ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000381424ENST00000539744ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-5UTRENST00000381424ENST00000458174ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000381424ENST00000445693ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-
intron-intronENST00000381424ENST00000413632ST8SIA1chr12

22401940

-IFLTD1chr12

25702480

-

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FusionProtFeatures for ST8SIA1_IFLTD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST8SIA1

Q92185

IFLTD1

Involved in the production of gangliosides GD3 and GT3from GM3; gangliosides are a subfamily of complexglycosphinglolipds that contain one or more residues of sialicacid. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8058740,ECO:0000269|PubMed:8195250, ECO:0000269|PubMed:8631981}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST8SIA1_IFLTD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ST8SIA1_ENST00000539510_chr12_22401940_-_IFLTD1_ENST00000282881_chr12_25702480_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ST8SIA1_ENST00000539510_chr12_22401940_-_IFLTD1_ENST00000282881_chr12_25702480_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_ST8SIA1_ENST00000539510_chr12_22401940_-_IFLTD1_ENST00000282881_chr12_25702480_-_1981nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGAAGAGAAGACA
AACTTGGAGTATATTCTTTAGTACATTTTTCCCCAAAGATGTTGGGTTCAGTTGCCACAACACTGCCATTGTCATCTTCAAATTCCAGTG
GAATGCCTCTTGGTTACTATCTGTCTAGTCCTCAGATTAGTAGAGTAACTATATCAACAACTGGACAATTGACTTCTAAAGCTACTGTAG
GTAGCTGTTCCAGAGTGGAAAACAGCTTGGATGCCAGCCCCTTCTCAGTTCCGAAGAAACAGGATGAATCACCCATGATTGGGGATGGAG
AAGATTATTTCCTTTCTTTGTTTGGTGATTCAAAGAAACTTACAGCACACTCAAACTACACTCAGAAAACTTTAAAATACTTTTCTATGA
TTCTTGAAGAAGTTGGCCAATTTACCTCCAGTTCTCTTGGAGATGTTGAAATAGCTGAAGTGAATGTCAAGGGTTTGTTCGTGAAGCTCA
TTAACTCTTCCCTTGACAAAGAAATGGCAATTGGAGATCATATTCTCCAGCAAAATGTGAATGGACAAACCATTTCTTTGTACCGATTCC
TTCCAAACATCGTAATGCAGGCAAATTCCACAGTAACAGTGTGGGCAGCAGCATCTGAAGCAAAGCATCAACCTCCATCAGATTTTCTTT
GGAAGGAACAAGACAAGTTTAGAGCAAGTCCTGATTGTATAACAATCCTGTGCAAACCGAACGGTCAAGCCATTGCGTGGTACACCCCTA
TCCACTGGAAGCAAGCGTGGGAAAAATTAGATGCTGACGTTGAATTTAACAGATGTTCAGTAGTATCTCCAACATTCCGAAAGCGTGTGT
TTCAGTGGACAGCATCTACAGCTACAATAACTAAAGAAAAACAAGATCAACCTAAGAAAGATATCTCAAATTATCAGGTGGAACAAGCTC
AAGTTCTTCTTAAGAGAGAGAAGGAAATCCCACCAACCGTTTTCCCTAATCGCAGCCCTTGGTGCCAGAATCCCTATGTCTCTGCACATC
CTTACTGTCCTCTGATTGAACCACACAATACATCCACCGCTGGAGGCAGATTGGATAGACAGCCCAGGACTCGGTCAACCAGACCTAATC
GAGCCTCAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGTAATCTAGTCCACCCTCA
ACCAGCTACTAGAAAAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCTGCTATTCCATGAGAGGGTGAAGACATCAC
ATTTCTATATGGAAAAAGGATCCAAAATTTGTATTGCTGTAGAATTGGTGAATTATAGATGCTTGATGAAATCACAAGTCCTACCACTCC
TGCCTTCCAAATCCCTGCAGAAAACAAGCAGATGGTTAGTATTATTCAATGGATAAAATTGCTATTTGCCTTAGATTTCTCTTTTTGTAA
ACAAAGTTATTTTGGGTACAGAACTCACAAAAGAAGAGCACGTGCAATTGTTTAACCATTTTACATTGACTGATAAATCTCTTTTTTCCA


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FusionGenePPI for ST8SIA1_IFLTD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST8SIA1POTEF, RPIA, BRAT1, INTS12, NMD3, IPO13, HOOK2, INTS1, RUFY1, ZMYM2IFLTD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST8SIA1_IFLTD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ST8SIA1_IFLTD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST8SIA1C0023895Liver diseases1CTD_human
HgeneST8SIA1C0235032Neurotoxicity Syndromes1CTD_human