FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 3628

FusionGeneSummary for AUTS2_NCOA3

check button Fusion gene summary
Fusion gene informationFusion gene name: AUTS2_NCOA3
Fusion gene ID: 3628
HgeneTgene
Gene symbol

AUTS2

NCOA3

Gene ID

26053

8202

Gene nameAUTS2, activator of transcription and developmental regulatornuclear receptor coactivator 3
SynonymsFBRSL2|MRD26ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP
Cytomap

7q11.22

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionautism susceptibility gene 2 proteinautism susceptibility candidate 2autism-related protein 1nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1
Modification date2018051920180523
UniProtAcc

Q8WXX7

Q9Y6Q9

Ensembl transtripts involved in fusion geneENST00000406775, ENST00000342771, 
ENST00000403018, ENST00000489774, 
ENST00000341724, ENST00000372004, 
ENST00000371998, ENST00000371997, 
ENST00000497292, 
Fusion gene scores* DoF score19 X 15 X 7=19959 X 6 X 4=216
# samples 199
** MAII scorelog2(19/1995*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AUTS2 [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAUTS2

GO:0045944

positive regulation of transcription by RNA polymerase II

25519132

HgeneAUTS2

GO:0051571

positive regulation of histone H3-K4 methylation

25519132

HgeneAUTS2

GO:2000620

positive regulation of histone H4-K16 acetylation

25519132

TgeneNCOA3

GO:0045944

positive regulation of transcription by RNA polymerase II

9267036

TgeneNCOA3

GO:0071392

cellular response to estradiol stimulus

15831516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTGCTTCGA-2G-AAFV-01AAUTS2chr7

70163606

+NCOA3chr20

46211927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000406775ENST00000341724AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000406775ENST00000372004AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000406775ENST00000371998AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000406775ENST00000371997AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-intronENST00000406775ENST00000497292AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000342771ENST00000341724AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000342771ENST00000372004AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000342771ENST00000371998AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-5UTRENST00000342771ENST00000371997AUTS2chr7

70163606

+NCOA3chr20

46211927

+
5CDS-intronENST00000342771ENST00000497292AUTS2chr7

70163606

+NCOA3chr20

46211927

+
intron-5UTRENST00000403018ENST00000341724AUTS2chr7

70163606

+NCOA3chr20

46211927

+
intron-5UTRENST00000403018ENST00000372004AUTS2chr7

70163606

+NCOA3chr20

46211927

+
intron-5UTRENST00000403018ENST00000371998AUTS2chr7

70163606

+NCOA3chr20

46211927

+
intron-5UTRENST00000403018ENST00000371997AUTS2chr7

70163606

+NCOA3chr20

46211927

+
intron-intronENST00000403018ENST00000497292AUTS2chr7

70163606

+NCOA3chr20

46211927

+
3UTR-5UTRENST00000489774ENST00000341724AUTS2chr7

70163606

+NCOA3chr20

46211927

+
3UTR-5UTRENST00000489774ENST00000372004AUTS2chr7

70163606

+NCOA3chr20

46211927

+
3UTR-5UTRENST00000489774ENST00000371998AUTS2chr7

70163606

+NCOA3chr20

46211927

+
3UTR-5UTRENST00000489774ENST00000371997AUTS2chr7

70163606

+NCOA3chr20

46211927

+
3UTR-intronENST00000489774ENST00000497292AUTS2chr7

70163606

+NCOA3chr20

46211927

+

Top

FusionProtFeatures for AUTS2_NCOA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AUTS2

Q8WXX7

NCOA3

Q9Y6Q9

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility (PubMed:25519132). ThePRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP andAUTS2 has decreased histone H2A ubiquitination activity, due tothe phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As aconsequence, the complex mediates transcriptional activation(PubMed:25519132). In the cytoplasm, plays a role in axon anddendrite elongation and in neuronal migration during embryonicbrain development. Promotes reorganization of the actincytoskeleton, lamellipodia formation and neurite elongation viaits interaction with RAC guanine nucleotide exchange factors,which then leads to the activation of RAC1 (By similarity).{ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AUTS2_NCOA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AUTS2_NCOA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AUTS2PCGF3, PCGF5, RNF2, CSNK2A2, RYBP, RING1, YAF2, CSNK2A1, CSNK2B, DCAF7, FBRS, EP300, RERE, RBM14, ZNF608, ZNF609, TLE3, WDR5, PCGF6, ATN1NCOA3AR, BRCA1, EP300, ANKRD11, NPAS2, NR3C1, YWHAQ, PRMT1, NR4A1, NR2F1, RXRA, CCND1, ESRRA, ESRRB, NKX2-1, CREBBP, ESR1, ESR2, NR0B2, NR5A2, NCOA2, TRIM21, IKBKG, IKBKB, CHUK, VDR, PGR, HIST3H3, HIST4H4, CARM1, ABL1, FOS, NCOR1, ETS1, ETS2, PPARG, NCOA1, THRA, STAT6, SMAD2, SMAD3, ATAD2, KAT2B, RARA, NCOR2, SPOP, CDKN3, IQCK, BRE, DCTN6, CSNK1E, RARG, NR1H3, NR1H2, THRB, SPTA1, MYH9, ACTA1, ANXA2, TPR, MORC2, NFATC3, PSME3, EIF3E, CUL3, NFKB1, MAPK14, MAPK1, MAPK8, GSK3B, RFX1, TP53BP1, PSMC5, PRKCZ, TFF1, PSMA3, MYOCD, CEBPA, CEBPD, UBE3A, E2F1, PIN1, ELAVL1, TP53, KANK2, NR1I2, ALB, MMS19, PTEN, FBXW7, ARNT2, PSMB9, ETV1, PPARD, PPARA, NR1I3, MN1, MKL1, MKL2, HNF1A, RELA, EWSR1, XPO1, XRCC5, TMEM132A, PIAS1, RAB28, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AUTS2_NCOA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AUTS2_NCOA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAUTS2C0036341Schizophrenia2PSYGENET
HgeneAUTS2C0014544Epilepsy1CTD_human
TgeneNCOA3C0023418leukemia2CTD_human
TgeneNCOA3C0033578Prostatic Neoplasms2CTD_human
TgeneNCOA3C0001418Adenocarcinoma1CTD_human
TgeneNCOA3C0004114Astrocytoma1CTD_human
TgeneNCOA3C0005967Bone neoplasms1CTD_human
TgeneNCOA3C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNCOA3C0007137Squamous cell carcinoma1CTD_human
TgeneNCOA3C1458155Mammary Neoplasms1CTD_human