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Fusion gene ID: 36261 |
FusionGeneSummary for ST6GALNAC2_JMJD6 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ST6GALNAC2_JMJD6 | Fusion gene ID: 36261 | Hgene | Tgene | Gene symbol | ST6GALNAC2 | JMJD6 | Gene ID | 10610 | 23210 |
Gene name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | arginine demethylase and lysine hydroxylase | |
Synonyms | SAITL1|SIAT7|SIAT7B|SIATL1|ST6GalNAII|STHM | PSR|PTDSR|PTDSR1 | |
Cytomap | 17q25.1 | 17q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferaseSIAT7-BST6 ( | bifunctional arginine demethylase and lysyl-hydroxylase JMJD6histone arginine demethylase JMJD6jmjC domain-containing protein 6jumonji domain containing 6jumonji domain-containing protein 6lysyl-hydroxylase JMJD6peptide-lysine 5-dioxygenase JMJD6ph | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9UJ37 | Q6NYC1 | |
Ensembl transtripts involved in fusion gene | ENST00000225276, ENST00000586520, | ENST00000445478, ENST00000397625, ENST00000585429, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 1=4 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/4*10)=1.32192809488736 | |
Context | PubMed: ST6GALNAC2 [Title/Abstract] AND JMJD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ST6GALNAC2 | GO:0006486 | protein glycosylation | 29251719 |
Hgene | ST6GALNAC2 | GO:0006493 | protein O-linked glycosylation | 10742600 |
Hgene | ST6GALNAC2 | GO:1990743 | protein sialylation | 10742600 |
Tgene | JMJD6 | GO:0018395 | peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine | 19574390 |
Tgene | JMJD6 | GO:0070078 | histone H3-R2 demethylation | 17947579 |
Tgene | JMJD6 | GO:0070079 | histone H4-R3 demethylation | 17947579 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0AM-01A | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000225276 | ENST00000445478 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
Frame-shift | ENST00000225276 | ENST00000397625 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
5CDS-intron | ENST00000225276 | ENST00000585429 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
5UTR-3CDS | ENST00000586520 | ENST00000445478 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
5UTR-3CDS | ENST00000586520 | ENST00000397625 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
5UTR-intron | ENST00000586520 | ENST00000585429 | ST6GALNAC2 | chr17 | 74574838 | - | JMJD6 | chr17 | 74716580 | - |
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FusionProtFeatures for ST6GALNAC2_JMJD6 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ST6GALNAC2 | JMJD6 |
Catalyzes the transfer of N-acetylneuraminyl groups ontoglycan chains in glycoproteins. {ECO:0000269|PubMed:10742600,ECO:0000269|PubMed:29251719}. | Dioxygenase that can both act as a histone argininedemethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylasethat catalyzes 5-hydroxylation on specific lysine residues oftarget proteins such as U2AF2/U2AF65 and LUC7L2. Acts as aregulator of RNA splicing by mediating 5-hydroxylation ofU2AF2/U2AF65, affecting the pre-mRNA splicing activity ofU2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenaseactivity, may act as an RNA hydroxylase, as suggested by itsability to bind single strand RNA. Also acts as an argininedemethylase which demethylates histone H3 at 'Arg-2' (H3R2me) andhistone H4 at 'Arg-3' (H4R3me), thereby playing a role in histonecode. However, histone arginine demethylation may not constitutethe primary activity in vivo. Has no histone lysine demethylaseactivity. Required for differentiation of multiple organs duringembryogenesis. Acts as a key regulator of hematopoieticdifferentiation: required for angiogenic sprouting by regulatingthe pre-mRNA splicing activity of U2AF2/U2AF65. Seems to benecessary for the regulation of macrophage cytokine responses.{ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390,ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ST6GALNAC2_JMJD6 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ST6GALNAC2_JMJD6 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ST6GALNAC2 | SMAD3 | JMJD6 | WAS, BRD4, LUC7L, RSRC1, CCNL2, CLK4, CDCA2, NSRP1, PHRF1, PRPF38A, LUC7L2, MFAP1, PRPF40A, RBM23, RBM25, SFSWAP, RSRC2, U2AF1, ZCCHC17, AEBP2, ANKEF1, C17orf97, CCNL1, CENPL, DIP2A, FAM9A, FGD5, GNA14, HIST1H2BJ, HMGXB4, LARP7, NFIX, NHP2, PSMC1, RSPO2, SLFN12, SLU7, STAC3, TAF1A, ZNF451, APEH, ASUN, CAND1, CARS, HIST1H4A, HSPA4, CRMP1, CYHR1, DNM1L, PAWR, SEC24A, STAT1, VPS26A, VPS29, XPO7, KARS, PPM1G, PPP2R5C, RANBP6, SHMT2, SWAP70, TROVE2, UBE2I, NAA50, FRMD6, MOV10, NXF1, ARL6IP4, DHX8, ZRSR2, SREK1, AP3B1, SSRP1, NAF1, AKAP17A, DDX46, PRPF38B, PAXBP1, PPIL4, TFIP11, CDK11B, CLK3, ARGLU1, CPSF6, NFKBIL1, CPSF7, CACTIN, SCAF11, SRSF11, CPSF4, USP42, ZMYM1, NKAP, U2AF2, DHX40, SCAF4, RBM26, ZC3H4, DHX38, SCAF1, RNPC3, WDR33, PPIG, SCAF8, C11orf57, PIP4K2A, WDR48, LUC7L3, UAP1, GTF2F1, CHERP, RBM27, TAF7, DIDO1, RBM39, ZNF24, NUDT21, HBS1L, RABL6, RNF138, PUF60, RBMX2, U2SURP, ZRSR1, TULP3, DKC1, RPS7, CAAP1, SETD2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ST6GALNAC2_JMJD6 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST6GALNAC2_JMJD6 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ST6GALNAC2 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |