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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36259

FusionGeneSummary for ST6GALNAC1_ZMAT5

check button Fusion gene summary
Fusion gene informationFusion gene name: ST6GALNAC1_ZMAT5
Fusion gene ID: 36259
HgeneTgene
Gene symbol

ST6GALNAC1

ZMAT5

Gene ID

55808

55954

Gene nameST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1zinc finger matrin-type 5
SynonymsHSY11339|SIAT7A|ST6GalNAcI|STYISNRNP20|U11/U12-20K|ZC3H19
Cytomap

17q25.1

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1GalNAc alpha-2, 6-sialyltransferase I, long formSIAT7-AST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1ST6 GalNAc alpha-2,6-sialyltzinc finger matrin-type protein 5U11/U12 small nuclear ribonucleoprotein 20 kDa proteinU11/U12 snRNP 20 kDa proteinU11/U12 snRNP 20Kzinc finger CCCH-type containing 19
Modification date2018052320180523
UniProtAcc

Q9NSC7

Q9UDW3

Ensembl transtripts involved in fusion geneENST00000156626, ENST00000590878, 
ENST00000589992, 
ENST00000344318, 
ENST00000397781, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 2 X 3=18
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ST6GALNAC1 [Title/Abstract] AND ZMAT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1425-01AST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000156626ENST00000344318ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
Frame-shiftENST00000156626ENST00000397781ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
5UTR-3CDSENST00000590878ENST00000344318ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
5UTR-3CDSENST00000590878ENST00000397781ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
Frame-shiftENST00000589992ENST00000344318ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-
Frame-shiftENST00000589992ENST00000397781ST6GALNAC1chr17

74639590

-ZMAT5chr22

30138469

-

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FusionProtFeatures for ST6GALNAC1_ZMAT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST6GALNAC1

Q9NSC7

ZMAT5

Q9UDW3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST6GALNAC1_ZMAT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ST6GALNAC1_ZMAT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST6GALNAC1EXOSC2, EEF1A2ZMAT5RNU11, WWOX, ZRSR2, RNU12, SNRPN, DENND4B, SNRPF, ZCRB1, PDCD7, RNPC3, SNRPG, SNRNP48, ACTA2, PSMG4, PSMG3, ACTBL2, CTU2, SNRPE, PSME3, GSTT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST6GALNAC1_ZMAT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ST6GALNAC1_ZMAT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST6GALNAC1C0033975Psychotic Disorders1PSYGENET
HgeneST6GALNAC1C0036341Schizophrenia1PSYGENET
HgeneST6GALNAC1C0349204Nonorganic psychosis1PSYGENET