FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 36254

FusionGeneSummary for ST6GAL1_PSMC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ST6GAL1_PSMC3
Fusion gene ID: 36254
HgeneTgene
Gene symbol

ST6GAL1

PSMC3

Gene ID

6480

5702

Gene nameST6 beta-galactoside alpha-2,6-sialyltransferase 1proteasome 26S subunit, ATPase 3
SynonymsSIAT1|ST6GalI|ST6NTBP1
Cytomap

3q27.3

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-galactoside alpha-2,6-sialyltransferase 1B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6 N-acetylgalactosaminide alpha-2,6-sialyl26S proteasome regulatory subunit 6A26S protease regulatory subunit 6A26S proteasome AAA-ATPase subunit RPT5Tat-binding protein 1human immunodeficiency virus tat transactivator binding protein-1proteasome (prosome, macropain) 26S subunit, ATPase, 3p
Modification date2018052320180523
UniProtAcc

P15907

P17980

Ensembl transtripts involved in fusion geneENST00000169298, ENST00000457772, 
ENST00000448044, ENST00000487031, 
ENST00000602866, ENST00000298852, 
ENST00000530912, 
Fusion gene scores* DoF score5 X 3 X 6=901 X 2 X 1=2
# samples 61
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: ST6GAL1 [Title/Abstract] AND PSMC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneST6GAL1

GO:0006054

N-acetylneuraminate metabolic process

23999306

HgeneST6GAL1

GO:0018279

protein N-linked glycosylation via asparagine

23999306

HgeneST6GAL1

GO:0097503

sialylation

23999306

TgenePSMC3

GO:0043921

modulation by host of viral transcription

2194290|8419915

TgenePSMC3

GO:0045944

positive regulation of transcription by RNA polymerase II

19853614


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J4-A67R-01AST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
TCGALDPRADTCGA-J4-A67R-01AST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000169298ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-3CDSENST00000169298ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-3CDSENST00000169298ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-3CDSENST00000457772ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-3CDSENST00000457772ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-3CDSENST00000457772ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000448044ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000448044ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000448044ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000487031ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000487031ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
intron-3CDSENST00000487031ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447501

-
5UTR-intronENST00000169298ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
5UTR-5UTRENST00000169298ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
5UTR-5UTRENST00000169298ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
5UTR-intronENST00000457772ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
5UTR-5UTRENST00000457772ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
5UTR-5UTRENST00000457772ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-intronENST00000448044ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-5UTRENST00000448044ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-5UTRENST00000448044ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-intronENST00000487031ENST00000602866ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-5UTRENST00000487031ENST00000298852ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-
intron-5UTRENST00000487031ENST00000530912ST6GAL1chr3

186681714

+PSMC3chr11

47447833

-

Top

FusionProtFeatures for ST6GAL1_PSMC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST6GAL1

P15907

PSMC3

P17980

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. {ECO:0000269|PubMed:21081508,ECO:0000269|PubMed:23999306}. Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC3 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ST6GAL1_PSMC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ST6GAL1_PSMC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST6GAL1ST6GAL1, KIAA1244, ATRIP, WAPAL, ZYG11B, GLMN, HOOK2, SAAL1, USP28, PRMT9, TNPO3, INTS3, INTS12, PIP4K2A, ERGIC2, HLA-C, HEATR3PSMC3TXNRD2, PSMD13, PSMD10, PSMD6, PAAF1, PSMC4, HTR1E, TRAF6, VHL, HIF1A, EPAS1, STX11, PSMC5, CDKN2A, PSMD7, UCHL5, USP14, PMS2, RNF185, UBC, MDM2, MYC, JKAMP, TP53, INSIG2, INSIG1, UBD, CIITA, PSMA3, SHFM1, MAP3K5, NDRG1, PSMC3, PSMD9, PSMC6, RAD23A, SIRT7, PSMC2, PARK2, FKBP8, PSMC1, PSMD8, PSMB5, PSMD2, PSMD1, FOSL1, STAT1, PSMC3IP, AR, UBE2I, TRAF4, SYN2, BAX, FBXO25, TXNL1, PSMA2, COPS2, ATXN1, SNCA, PSMD11, PSMD12, PSMD3, PSMD4, PSMD14, PSMA5, PSMA6, PSMA7, PSMB7, PSMB1, PSMA1, PSMB3, PSMB4, PSMB2, PSMB6, PSMB8, PSMA8, UBFD1, RANBP9, ZFYVE16, RUVBL1, ECD, STIP1, NOS2, BAG3, GADD45A, FBXO6, AMOTL2, ADRM1, ASB11, HUWE1, KDM1A, SHMT2, MOV10, NXF1, UBE3A, ZFAND2B, CCDC74B, CCDC92, RASSF7, EIF4G1, EIF4G3, RAI14, CSRP2BP, ZZZ3, YEATS2, KIF1A, KIF1B, FLYWCH2, NFRKB, TPD52L1, FBXO28, FAM117B, LIN54, RPL23, LRIF1, MGA, MBIP, GTF2F1, MPRIP, TBC1D2B, SLMAP, CHD8, PARD3, DR1, TADA2A, GARS, PNN, EIF2D, DIAPH1, RNF2, ITPR2, L3MBTL2, WNK2, STKLD1, PEX6, ELF2, PMS1, TSEN15, NEDD1, SPATS2, FAM83D, KXD1, ATG16L1, MAVS, UBXN1, RNASEH2C, TSR3, ARHGEF1, E2F6, CXXC1, MAP3K7, C9orf156, PSMB9, RPS6KB2, AMBRA1, BASP1, NAA15, PHB2, PSMA4, CAD, MTCH1, POMP, PSMD5, PSMG2, RFC2, RPN1, NTRK1, TMEM67, CCDC93, CRY2, EPM2A, SNW1, CDC5L, RC3H1, UBLCP1, PHF19, CCDC40, SCML1, TAB1, MARK4, EIF2AK4, MEX3D, INTU, CYLD, DLD, DNM1L, CCND2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ST6GAL1_PSMC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ST6GAL1_PSMC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST6GAL1C0001969Alcoholic Intoxication1PSYGENET
HgeneST6GAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneST6GAL1C0162820Dermatitis, Allergic Contact1CTD_human
HgeneST6GAL1C0337677Moderate drinker1PSYGENET
TgenePSMC3C0019693HIV Infections1CTD_human