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Fusion gene ID: 36253 |
FusionGeneSummary for ST6GAL1_LPP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ST6GAL1_LPP | Fusion gene ID: 36253 | Hgene | Tgene | Gene symbol | ST6GAL1 | LPP | Gene ID | 6480 | 4026 |
| Gene name | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 | LIM domain containing preferred translocation partner in lipoma | |
| Synonyms | SIAT1|ST6GalI|ST6N | - | |
| Cytomap | 3q27.3 | 3q27.3-q28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-galactoside alpha-2,6-sialyltransferase 1B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6 N-acetylgalactosaminide alpha-2,6-sialyl | lipoma-preferred partnerLIM proteinlipoma preferred partner | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P15907 | Q93052 | |
| Ensembl transtripts involved in fusion gene | ENST00000169298, ENST00000457772, ENST00000448044, ENST00000487031, | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | |
| Fusion gene scores | * DoF score | 5 X 3 X 6=90 | 12 X 17 X 5=1020 |
| # samples | 6 | 20 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1020*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ST6GAL1 [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ST6GAL1 | GO:0006054 | N-acetylneuraminate metabolic process | 23999306 |
| Hgene | ST6GAL1 | GO:0018279 | protein N-linked glycosylation via asparagine | 23999306 |
| Hgene | ST6GAL1 | GO:0097503 | sialylation | 23999306 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-DZ-6131-01A | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000169298 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000169298 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| 5UTR-intron | ENST00000457772 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000448044 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000448637 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000312675 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000543006 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
| intron-intron | ENST00000487031 | ENST00000471917 | ST6GAL1 | chr3 | 186681714 | + | LPP | chr3 | 188583988 | + |
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FusionProtFeatures for ST6GAL1_LPP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ST6GAL1 | LPP |
| Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. {ECO:0000269|PubMed:21081508,ECO:0000269|PubMed:23999306}. | May play a structural role at sites of cell adhesion inmaintaining cell shape and motility. In addition to thesestructural functions, it may also be implicated in signalingevents and activation of gene transcription. May be involved insignal transduction from cell adhesion sites to the nucleusallowing successful integration of signals arising from solublefactors and cell-cell adhesion sites. Also suggested to serve as ascaffold protein upon which distinct protein complexes areassembled in the cytoplasm and in the nucleus.{ECO:0000269|PubMed:10637295, ECO:0000269|Ref.2}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ST6GAL1_LPP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ST6GAL1_LPP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ST6GAL1 | ST6GAL1, KIAA1244, ATRIP, WAPAL, ZYG11B, GLMN, HOOK2, SAAL1, USP28, PRMT9, TNPO3, INTS3, INTS12, PIP4K2A, ERGIC2, HLA-C, HEATR3 | LPP | ATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ST6GAL1_LPP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST6GAL1_LPP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ST6GAL1 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
| Hgene | ST6GAL1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | ST6GAL1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Hgene | ST6GAL1 | C0337677 | Moderate drinker | 1 | PSYGENET |
| Tgene | LPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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