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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36249

FusionGeneSummary for ST5_GPT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ST5_GPT2
Fusion gene ID: 36249
HgeneTgene
Gene symbol

ST5

GPT2

Gene ID

6764

84706

Gene namesuppression of tumorigenicity 5glutamic--pyruvic transaminase 2
SynonymsDENND2B|HTS1|p126ALT2|GPT 2|MRT49
Cytomap

11p15.4

16q11.2

Type of geneprotein-codingprotein-coding
Descriptionsuppression of tumorigenicity 5 proteinDENN/MADD domain containing 2BheLa tumor suppression 1alanine aminotransferase 2glutamate pyruvate transaminase 2glutamic pyruvate transaminase (alanine aminotransferase) 2glutamic pyruvate transaminase 2glutamic--alanine transaminase 2
Modification date2018051920180519
UniProtAcc

P78524

Q8TD30

Ensembl transtripts involved in fusion geneENST00000526757, ENST00000534127, 
ENST00000313726, ENST00000357665, 
ENST00000530438, ENST00000530991, 
ENST00000526099, ENST00000534278, 
ENST00000531237, 
ENST00000340124, 
ENST00000440783, 
Fusion gene scores* DoF score4 X 5 X 5=1003 X 3 X 2=18
# samples 54
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ST5 [Title/Abstract] AND GPT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPT2

GO:0006103

2-oxoglutarate metabolic process

11863375

TgeneGPT2

GO:0042851

L-alanine metabolic process

11863375


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF772696ST5chr11

8737284

-GPT2chr16

46958329

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000526757ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000526757ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000534127ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000534127ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000313726ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000313726ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000357665ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000357665ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000530438ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000530438ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000530991ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000530991ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000526099ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000526099ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000534278ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000534278ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000531237ENST00000340124ST5chr11

8737284

-GPT2chr16

46958329

-
intron-3CDSENST00000531237ENST00000440783ST5chr11

8737284

-GPT2chr16

46958329

-

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FusionProtFeatures for ST5_GPT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST5

P78524

GPT2

Q8TD30

Catalyzes the reversible transamination between alanineand 2-oxoglutarate to form pyruvate and glutamate.{ECO:0000269|PubMed:11863375}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST5_GPT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ST5_GPT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST5_GPT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGPT2Q8TD30DB00780PhenelzineAlanine aminotransferase 2small moleculeapproved
TgeneGPT2Q8TD30DB00114Pyridoxal PhosphateAlanine aminotransferase 2small moleculeapproved|investigational|nutraceutical
TgeneGPT2Q8TD30DB00142Glutamic AcidAlanine aminotransferase 2small moleculeapproved|nutraceutical

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RelatedDiseases for ST5_GPT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPT2C4225388MENTAL RETARDATION, AUTOSOMAL RECESSIVE 491UNIPROT