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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 36235

FusionGeneSummary for ST3GAL3_TIE1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL3_TIE1
Fusion gene ID: 36235
HgeneTgene
Gene symbol

ST3GAL3

TIE1

Gene ID

6487

7075

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 3tyrosine kinase with immunoglobulin like and EGF like domains 1
SynonymsEIEE15|MRT12|SIAT6|ST3GALII|ST3Gal III|ST3GalIII|ST3NJTK14|TIE
Cytomap

1p34.1

1p34.2

Type of geneprotein-codingprotein-coding
DescriptionCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sityrosine-protein kinase receptor Tie-1tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Modification date2018052420180523
UniProtAcc

Q11203

P35590

Ensembl transtripts involved in fusion geneENST00000262915, ENST00000372375, 
ENST00000351035, ENST00000372374, 
ENST00000353126, ENST00000545417, 
ENST00000330208, ENST00000335430, 
ENST00000372377, ENST00000361392, 
ENST00000361400, ENST00000347631, 
ENST00000361812, ENST00000372362, 
ENST00000531451, ENST00000372366, 
ENST00000372365, ENST00000372368, 
ENST00000332628, ENST00000372372, 
ENST00000531816, ENST00000528371, 
ENST00000372369, ENST00000531993, 
ENST00000361746, ENST00000533933, 
ENST00000372367, ENST00000461375, 
ENST00000372476, ENST00000433781, 
ENST00000538015, ENST00000441333, 
ENST00000473014, 
Fusion gene scores* DoF score9 X 6 X 8=4321 X 1 X 1=1
# samples 91
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ST3GAL3 [Title/Abstract] AND TIE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-BK-A139-02AST3GAL3chr1

44303983

+TIE1chr1

43770522

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000262915ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000262915ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000262915ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000262915ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000262915ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372375ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372375ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372375ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372375ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372375ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000351035ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000351035ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000351035ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000351035ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000351035ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-3CDSENST00000372374ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000372374ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000372374ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000372374ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000372374ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000353126ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000353126ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000353126ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000353126ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000353126ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000545417ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000545417ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000545417ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000545417ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000545417ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000330208ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000330208ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000330208ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000330208ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000330208ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000335430ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000335430ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000335430ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000335430ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000335430ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372377ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372377ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372377ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372377ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372377ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000361392ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361392ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361392ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361392ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361392ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000361400ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361400ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361400ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361400ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361400ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000347631ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000347631ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000347631ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000347631ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000347631ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000361812ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361812ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361812ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361812ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361812ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372362ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372362ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372362ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372362ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372362ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000531451ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531451ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531451ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531451ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531451ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372366ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372366ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372366ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372366ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372366ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372365ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372365ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372365ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372365ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372365ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372368ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372368ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372368ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372368ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372368ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-3CDSENST00000332628ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000332628ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000332628ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000332628ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
intron-intronENST00000332628ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372372ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372372ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372372ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372372ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372372ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000531816ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531816ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531816ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531816ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531816ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000528371ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000528371ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000528371ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000528371ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000528371ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372369ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372369ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372369ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372369ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372369ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000531993ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531993ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531993ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531993ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000531993ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000361746ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361746ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361746ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361746ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000361746ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000533933ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000533933ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000533933ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000533933ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000533933ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
Frame-shitENST00000372367ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372367ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372367ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372367ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
5CDS-intronENST00000372367ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
3UTR-3CDSENST00000461375ENST00000372476ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
3UTR-intronENST00000461375ENST00000433781ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
3UTR-intronENST00000461375ENST00000538015ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
3UTR-intronENST00000461375ENST00000441333ST3GAL3chr1

44303983

+TIE1chr1

43770522

+
3UTR-intronENST00000461375ENST00000473014ST3GAL3chr1

44303983

+TIE1chr1

43770522

+

Top

FusionProtFeatures for ST3GAL3_TIE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ST3GAL3

Q11203

TIE1

P35590

Transmembrane tyrosine-protein kinase that may modulateTEK/TIE2 activity and contribute to the regulation ofangiogenesis. {ECO:0000269|PubMed:20227369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ST3GAL3_TIE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ST3GAL3_TIE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ST3GAL3ACTG1, SCAMP2, ZBTB5, RPL8TIE1ANGPT4, TEK, MYC, HSP90AA1, MDFI, PSG5, RBPMS, KRT40, MTMR14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ST3GAL3_TIE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ST3GAL3_TIE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneST3GAL3C1970200MENTAL RETARDATION, AUTOSOMAL RECESSIVE 121UNIPROT
HgeneST3GAL3C3554316EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 151UNIPROT