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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36208

FusionGeneSummary for SSU72_PCBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: SSU72_PCBP3
Fusion gene ID: 36208
HgeneTgene
Gene symbol

SSU72

PCBP3

Gene ID

29101

54039

Gene nameSSU72 homolog, RNA polymerase II CTD phosphatasepoly(rC) binding protein 3
SynonymsHSPC182|PNAS-120ALPHA-CP3|PCBP3-OT1|PCBP3OT
Cytomap

1p36.33

21q22.3

Type of geneprotein-codingprotein-coding
DescriptionRNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72poly(rC)-binding protein 3PCBP3 overlapping transcript 1PCBP3-overlapping transcriptpoly(rC) binding protein 3 overlapping transcript
Modification date2018052320180519
UniProtAcc

Q9NP77

P57721

Ensembl transtripts involved in fusion geneENST00000291386, ENST00000359060, 
ENST00000400314, ENST00000400310, 
ENST00000449640, ENST00000400309, 
ENST00000400308, ENST00000400304, 
ENST00000423045, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 4=64
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSU72 [Title/Abstract] AND PCBP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSSU72

GO:0070940

dephosphorylation of RNA polymerase II C-terminal domain

20861839


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF818292SSU72chr1

1477338

-PCBP3chr21

47352576

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000291386ENST00000400314SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000400310SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000449640SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000400309SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000400308SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000400304SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000291386ENST00000423045SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000400314SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000400310SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000449640SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000400309SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000400308SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000400304SSU72chr1

1477338

-PCBP3chr21

47352576

-
intron-intronENST00000359060ENST00000423045SSU72chr1

1477338

-PCBP3chr21

47352576

-

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FusionProtFeatures for SSU72_PCBP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSU72

Q9NP77

PCBP3

P57721

Protein phosphatase that catalyzes the dephosphorylationof the C-terminal domain of RNA polymerase II. Plays a role in RNAprocessing and termination. Plays a role in pre-mRNApolyadenylation via its interaction with SYMPK.{ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839,ECO:0000269|PubMed:23070812}. Single-stranded nucleic acid binding protein that bindspreferentially to oligo dC. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSU72_PCBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSU72_PCBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSU72_PCBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSU72_PCBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource