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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 36180

FusionGeneSummary for SSR1_PSMA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR1_PSMA1
Fusion gene ID: 36180
HgeneTgene
Gene symbol

SSR1

PSMA1

Gene ID

6745

5682

Gene namesignal sequence receptor subunit 1proteasome subunit alpha 1
SynonymsTRAPAHC2|HEL-S-275|NU|PROS30
Cytomap

6p24.3

11p15.2

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunitproteasome subunit alpha type-130 kDa prosomal proteinPROS-30epididymis secretory protein Li 275macropain subunit C2macropain subunit numulticatalytic endopeptidase complex subunit C2proteasome (prosome, macropain) subunit, alpha type, 1proteasome
Modification date2018052320180523
UniProtAcc

P43307

P25786

Ensembl transtripts involved in fusion geneENST00000488834, ENST00000474597, 
ENST00000244763, ENST00000397511, 
ENST00000534851, ENST00000489567, 
ENST00000479365, ENST00000462112, 
ENST00000418988, ENST00000555531, 
ENST00000419365, ENST00000524606, 
ENST00000396394, ENST00000396393, 
ENST00000530457, 
Fusion gene scores* DoF score10 X 11 X 4=4406 X 4 X 6=144
# samples 116
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSR1 [Title/Abstract] AND PSMA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP386202SSR1chr6

7281915

+PSMA1chr11

14526610

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488834ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000488834ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000488834ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000488834ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000488834ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000488834ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000488834ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000474597ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000474597ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000474597ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000474597ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000474597ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000474597ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000474597ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000244763ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000244763ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000244763ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000244763ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000244763ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000244763ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000244763ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000397511ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000397511ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000397511ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000397511ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000397511ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000397511ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000397511ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000534851ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000534851ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000534851ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000534851ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000534851ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000534851ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000534851ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000489567ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000489567ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000489567ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000489567ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000489567ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000489567ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000489567ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000479365ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000479365ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000479365ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000479365ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000479365ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000479365ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000479365ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000462112ENST00000418988SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000462112ENST00000555531SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-intronENST00000462112ENST00000419365SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-5UTRENST00000462112ENST00000524606SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000462112ENST00000396394SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000462112ENST00000396393SSR1chr6

7281915

+PSMA1chr11

14526610

-
intron-3UTRENST00000462112ENST00000530457SSR1chr6

7281915

+PSMA1chr11

14526610

-

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FusionProtFeatures for SSR1_PSMA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSR1

P43307

PSMA1

P25786

Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SSR1_PSMA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SSR1_PSMA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SSR1_PSMA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SSR1_PSMA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource